Reserpine causes biphasic nociceptive sensitivity alteration in conjunction with brain biogenic amine tones in rats

Oe, Tomoya; Tsukamoto, Mina; Nagakura, Yukinori

doi:10.1016/j.neuroscience.2010.06.061

Cited by 41 publications

(31 citation statements)

References 49 publications

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“…Reserpine is a monoamine depletor that blocks the vesicular monoamine transporter for neuronal transmission or storage, thus promoting oxidative catabolism by MAO (Lohr et al, 2003); this makes its injection a reliable model of depression in rodents (Oe et al, 2010). Results of the present study revealed that acute reserpine injection resulted in depressive-like behaviors such as decrease in the mice activity in the activity cage, increased immobility durations in both the TST and FST along with other physiological changes represented by prolonged monoamines depletion and oxidative stress.…”

Section: Discussionmentioning

confidence: 56%

Combination of resveratrol and fluoxetine in an acute model of depression in mice: Prevention of oxidative DNA fragmentation and monoamines degradation

Ahmed-Farid¹,

Ahmed²,

Saleh³

2016

J App Pharm Sci

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Resveratrol (RSV) is a natural polyphenol with diverse biological activities, including potent hepato-protective and antidepressant-like effects. Fluoxetine (FLX) is one of the most commonly prescribed antidepressant drugs, however; it has recently been postulated to induce liver damage. The present study aimed to assess the benefits of combining half the conventional doses of RSV and FLX in an acute reserpin e model of depression. Depression was induced in mice by a single i.p. reserpine injection. Oral administration of FLX (10 mg/kg), RSV (80 mg/kg) or their combination (FLX; 5 mg/kg and RSV; 40mg/kg) started one hour after reserpine injection and daily for the following two consecutive days. Behavioral tests were performed on the third day. Brain monoamines were assessed. Prevention of neurodegeneration and preservation potential of the DNA integrity were determined according to the brain nitric oxide and 8-hydroxy-2-deoxyguanosine contents. Effect on oxidative stress in both brain and liver was evaluated. Results revealed that combining half the dose of FLX with RSV showed antidepressant activity that was comparable to the effect of using FLX alone and in conclusion; we recommend that further investigations should be conducted to assess the applicability of using combinations of RSV and FLX to treat depression.

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Section: Discussionmentioning

confidence: 56%

Combination of resveratrol and fluoxetine in an acute model of depression in mice: Prevention of oxidative DNA fragmentation and monoamines degradation

Ahmed-Farid¹,

Ahmed²,

Saleh³

2016

J App Pharm Sci

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“…In line with this, both male and female RIM rats show a reduced muscle pressure threshold and tactile allodynia for at least one week after injection. Cold and heat hypersensitivities have also been reported to follow reserpine treatment (Oe et al, 2010), paralleling the hypersensitivities to mechanical and thermal stimuli seen in fibromyalgia patients. In addition to chronic widespread pain symptoms, fibromyalgia is also characterized by comorbid affective disorders such as depression.…”

Section: Face Validitymentioning

confidence: 82%

“…Further, reserpine treatment also induces a depressive condition, consistent with the role biogenic amines have in the pathophysiology of depression. Because a short-term depletion of biogenic amines by tetrabenazine did not significantly affect nociceptive sensitivities, long-term depletion is likely necessary for chronic pain symptoms to develop (Nagakura et al, 2009;Oe et al, 2010). Intriguingly, in the experiment using single injection of reserpine, hyposensitivity to muscle pressure stimulus occurred in the acute phase (within 24 h) after the reserpine injection, although hypersensitivity developed in the chronic phase, i.e., on Day 2 or later after the injection.…”

Section: Constructive Validitymentioning

confidence: 95%

“…Intriguingly, in the experiment using single injection of reserpine, hyposensitivity to muscle pressure stimulus occurred in the acute phase (within 24 h) after the reserpine injection, although hypersensitivity developed in the chronic phase, i.e., on Day 2 or later after the injection. The dynamic change of brain biogenic amine tones observed after the single injection of reserpine, which was indicated by the ratio of biogenic amine metabolite/biogenic amine, in the central nervous system seemed to correlate with the determination of nociceptive sensitivity (Oe et al, 2010).…”

Section: Constructive Validitymentioning

confidence: 96%

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Animal Models of Fibromyalgia

Nagakura¹,

Ito²,

Shimizu³

2012

New Insights Into Fibromyalgia

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“…Acid-sensing ion channel 3 (ASIC3) mRNA was upregulated in the DRG. In the spinal cord, function of the descending pain inhibitory system seems to be impaired because of a dramatic depletion of serotonin (5-HT) and noradrenaline (NA) in this model 7,11) . Activated microglia is evident in the spinal dorsal horn, especially in superficial laminae I-II, resulting in central sensitization.…”

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confidence: 93%

Pathological mechanisms of fibromyalgia using animal models

Taguchi¹

2017

Pain Research

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Fibromyalgia is characterized by systemic chronic pain. It accompanies a wide variety of symptoms, such as dysfunction in the autonomic nervous system, mental states, and locomotive activities. Fibromyalgia and related disorders are assumed to be heterogenous conditions with complicated pathologies driven by peripheral and central mechanisms. Using a reserpineinduced fibromyalgia model, a significant increase of mRNA expression in the dorsal root ganglion (DRG) was detected in the acid-sensing ion channel 3 (ASIC3) among several ion channels tested, which are responsible for pain, mechano-transduction, and the generation ⁄ propagation of action potentials. Behavioral mechanical hyperalgesia in this model was reversed by a selective blocker of ASIC3 (APETx2). Ex vivo single-fiber electrophysiological recordings revealed facilitation in the mechanical responses of mechano-responsive C-fibers both in the skin and muscle, whereas the proportion of mechanorespon sive C-nociceptors was paradoxically decreased. In the spinal dorsal horn microglial cells labeled with Iba1-immunoreactivity were obviously activated, especially in laminae I-II where the nociceptive input is mainly projected. Intraperitoneal injection of minocycline, which was applied preemptively and repeatedly for 4 consecutive days from 1 day before a series of reserpine injections, clearly suppressed the microglial activation and behavioral hyperalgesia. These results suggest that the increase in ASIC3 in the nociceptive afferents facili tated mechanical response of the remaining C-nociceptors, and that activated spinal microglia direct to intensify pain in this model. Pain may be further amplified by reserpine-induced dysfunction of the descending pain inhibi tory system, and by the decreased peripheral drive to this system resulting from a reduced proportion of mechano-responsive C-nociceptors.Persistent physical and psychological stress are associated with fibromyalgia. Changes in muscular nociceptors were systematically examined using two pain models induced by stress (repeated cold stress (RCS) and multiple continuous stress (MCS)). Mechanical response of C-nociceptors in RCS model was signifi cantly facilitated, whereas that in MCS model was unchanged. The result suggests that augmentation in the mechanical response of muscular C-

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Reserpine causes biphasic nociceptive sensitivity alteration in conjunction with brain biogenic amine tones in rats

Cited by 41 publications

References 49 publications

Combination of resveratrol and fluoxetine in an acute model of depression in mice: Prevention of oxidative DNA fragmentation and monoamines degradation

Combination of resveratrol and fluoxetine in an acute model of depression in mice: Prevention of oxidative DNA fragmentation and monoamines degradation

Animal Models of Fibromyalgia

Pathological mechanisms of fibromyalgia using animal models

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