Resection of Locally Recurrent Colorectal Cancer in the Presence of Distant Metastases: Can It Be Justified?

Abstract

The presence of M1 disease per se should not preclude resection of local recurrence, although case selection is problematic.

Surgical management and outcome of metachronous Krukenberg tumors from gastric cancer

“…Similar observations were made in local recurrences of colorectal cancer. The authors suggested that absence of gross residual tumor after resection was an independent prognostic factor [15,16]. Of note, the extent of disease correlated significantly with both the overall and progression free survival.…”

“…The median overall survival time according to the extent of the disease was 18 months (95% CI, [17][18][19] for the disease limited to the ovaries, 17 months (95% CI, 2-32) for the disease confined to the pelvis, and 9 months (95% CI, [3][4][5][6][7][8][9][10][11][12][13][14][15] for the disease beyond the pelvic cavity (P ¼ 0.0005) (Fig. 2).…”

S3-Guidelines Colorectal Cancer 2004

“…bietet sich die Umstellung der Therapie auf FOLFIRI an [539]. Nach 5-FU-Monotherapie sind Therapiemöglichkeiten die Irinotecan-Monotherapie [117,465] gestellt werden [226]. Zur lokalen Tumorbehandlung besteht die Möglichkeit einer Stentversorgung [38,44,330,529,544,568] oder Durchführung einer Laser-bzw.…”

Clinical Algorithms for the Surgical Management of Locally Recurrent Rectal Cancer

“…Provided distant deposits are resectable, highly selected patients can still experience good outcomes and survival beyond 5 years is possible. [32][33][34][35][36][37][38] Where outcome data were not described, or inseparably grouped together for patients with different pathologies (eg, recurrent rectal and cervical) or different treatments (eg, radiotherapy alone or combined with surgery), the fields are left blank. Where results have been provided for both curative and palliative procedures, the overall results for patients undergoing surgery are presented.…”

“…[32][33][34][35][36][37][38] It is the authors' preference to treat the local recurrence ahead of metastatectomy. Relative and absolute contraindications to resection are listed in Table 3 (including examples in Figs.…”