Resection of liver metastasis from neuroendocrine tumors: evaluation of results and prognostic factors

Abstract

Results ResultsResults Results: twelve patients were male and ten female, with a mean age of 48.5 years. Bilobar disease was present in 17 patients (77.3%). In ten patients (45.5%) the primary tumor originated in the pancreas, terminal ileum in eight, duodenum in two, rectum in one and jejunum in one. Complete surgical resection (R0) was achieved in 59.1% of patients. Eight patients (36.3%) developed complications in the immediate postoperative period, one of them dying from septicemia. All patients undergoing re-hepatectomy and/or two-stage hepatectomy had complications in the postoperative period. The overall survival at one and five years was 77.3% and 44.2%. The diseasefree survival at five years was 13.6%. The primary pancreatic neuroendocrine tumor (p = 0.006) was associated with reduced overall survival. Patients with number of metastatic nodules < 10 (p = 0.03) and asymptomatic at diagnosis (p = 0.015) had higher disease-free survival. ConclusionConclusion Conclusion Conclusion Conclusion: liver metastases originating from pancreatic neuroendocrine tumors proved to be a negative prognostic factor. Symptomatic patients with multiple metastatic nodules showed a significant reduction in diseasefree survival.

Management and outcomes of patients with recurrent neuroendocrine liver metastasis after curative surgery: An international multi‐institutional analysis

“…While management strategies for NELM include non‐surgical approaches such as intra‐arterial (IAT) or systemic targeted agents, as well as octreotide and tyrosine kinases inhibitors, surgery offers the best potential for cure . Surgical resection of NELM has been associated with 5‐year OS ranging from 61% to 76% and 10‐year survival of 35% to 51% .…”

“…7 While management strategies for NELM include non-surgical approaches such as intra-arterial (IAT) or systemic targeted agents, [8][9][10][11][12][13][14] as well as octreotide and tyrosine kinases inhibitors, [11][12][13] surgery offers the best potential for cure. 6,15,16 Surgical resection of NELM has been associated with 5-year OS ranging from 61% to 76% and 10-year survival of 35% to 51%. 17,18 Our group had previously reported that statistical cure following resection of NELM was 44% within 5.1 years after surgery.…”

Analysis of B-ultrasound and contrast-enhanced ultrasound characteristics of different hepatic neuroendocrine neoplasm

“…The possible reason is that hNENs are transferred from different sources. The blood flow supply composition is different, which results in a different washout time than HCC[21,22]. In addition, the proportions of CEUS characteristics, including enhancement of arterial phase, portal venous phase, and enhancement of late phase, enhancement forms, tumor vasculature, tumor necrosis, and capsule enhancement, were similar in the hNEN and HCC groups.…”

Primary Neuroendocrine Tumor of Liver (Rare Tumor of Liver)

“…Hepatic resection was a treatment of choice for neuroendocrines tumor of the liver ( 5 ). Neuroendocrine tumors, have although considered slow growing tumors and mildly aggressive, tend to develop distant metastatic disease with relative frequency, and the liver was the most affected organ ( 6 ). For patients with restricted but unresectable liver disease, transplantation has appeared to be the best therapeutic alternative ( 7 ).…”