Primary Neuroendocrine Tumor of Liver (Rare Tumor of Liver)

Mousavi, Seyed Reza; Ahadi, Mahsa

doi:10.17795/ijcp-3144

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…For the PNET liver metastasis patients, besides the resection of liver metastatic lesions, it is more important to find the primary site of pancreas, because it has great impact on the patient's outcome by resection of the primary pancreatic tumor (4). We should be aware of, primary liver-NET, is an extremely rare occurrence, and until 2015, there were only less than 150 reported cases in the English literature (7). So, once we detected PNET in liver, ought to try to identify the primary for an optimal therapy.…”

Section: Discussionmentioning

confidence: 97%

Combined associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) followed by left trisectionectomy and Whipple operation for PNET

Ji¹,

Zuo²,

Qiu³

et al. 2018

Gland Surg.

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Pancreatic neuroendocrine tumor (PNET) is slow-growing, and account only for 2% of all pancreatic primary tumors. Surgical resection is still the only curative treatment for PNET patients. Unfortunately, most of PNETs was found with unresectable multiple liver metastases and extrahepatic metastasis as their characteristics of non-functional and asymptomatic. With advances in liver surgery in these years, especially combined associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), provide a new curative surgical treatment for PNET with liver metastases patient. Here we report a PNET with multiple liver metastases case underwent ALPPS (followed by left trisectionectomy) and Whipple operation within one-stage.

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Section: Discussionmentioning

confidence: 97%

Combined associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) followed by left trisectionectomy and Whipple operation for PNET

Ji¹,

Zuo²,

Qiu³

et al. 2018

Gland Surg.

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“…Therefore, it is important to examine the whole body to find any possibility of another lesion. In some reports, In-111 octreotide scintigraphy is considered useful for whole-body screening with sensitivity of 80–90% [ 5 , 6 ]. In our case, the malignant tumor cannot be diagnosed as a NET preoperatively and octreotide scan was not performed.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumor arising from the greater omentum treated with laparoscopic tumor resection: a case report

et al. 2021

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Background Primary omental tumors are extremely rare. Herein, we report the first case of a primary omental neuroendocrine tumor (NET). Case presentation A 59-year-old woman was referred to our hospital for the treatment of an 18-mm tumor located at the ventral side of the duodenum. No other tumor was detected. The preoperative imaging diagnosis was omental tumor. A laparoscopic tumor resection was performed. Histopathological examination revealed that the tumor consisted of cuboidal cells with eosinophilic, granular cytoplasm showing trabecular or ribbon architecture. No other component was seen. The mitotic count was of 5 per 10 high-power fields. Immunohistochemical staining was positive for chromogranin A, synaptophysin, and CD56. Her Ki-67 index was 5%. These results led to the diagnosis of grade 2 omental NET. The patient was discharged on the 3rd postoperative day without any complications and did not develop any recurrence for 3 years. Conclusions We encountered a very rare case of omental NET. Complete resection is recommended with minimally invasive surgery for the diagnosis of NET.

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“…There are also controversial reports about when to call these liver-NETs “primary liver neuroendocrine tumors.” However, it seems that all the imaging (including octreotide scanning) and pathological modalities should be applied before calling a NET in the liver as the primary. Primary liver-NET is an extremely rare occurrence, and less than 150 cases have been reported in the English literature so far ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Liver Metastasis of Gastrointestinal Neuroendocrine Tumors: A Single Center Experience

2016

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Background: Gastrointestinal neuroendocrine tumors (GI-NETs) are potentially malignant tumors, and their most common location of metastasis is the liver. Objectives: In this report, we will describe our experience with some clinical and pathologic findings of hepatic metastasis in a group of cases of GI-NETs at the largest referral center of GI and liver diseases in south Iran. Materials and Methods:In this four-year study (2011 -2014), all GI and liver NETs were extracted from the pathology files of hospitals affiliated with Shiraz University of Medical Sciences. After classification based on the world health organization guidelines, the patients were evaluated according to their location, sex, age, and proliferative index. After studying the imaging and clinical charts of liver-NET cases with an unknown primary location, a complete panel of immunohistochemical markers (TTF-1, CDX-2, CK-7, CK-2, etc.) was used to find the primary GI location. Carcinoid tumors from other sites, such as the lung, were omitted from this study. Results:The most common primary site of metastatic GI-NET to the liver in our center was the small intestine, which was also the most frequent location of GI-NET without liver metastasis. No cases of appendiceal-NET were found with liver metastasis. In 8 cases (11.6%) with liver-NETs, no primary location was identified. GI-NETs with liver metastasis had a significantly higher grade and proliferative index compared with NETs without liver metastasis. Conclusions: Liver metastasis of neuroendocrine tumors in Iran presents in a very similar manner as that seen in western countries. In about 89% of cases with liver-NET, complete imaging, clinical, and pathological studies can help to identify the primary origin of the liver-NET, which is very important in the patient's management.

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Primary Neuroendocrine Tumor of Liver (Rare Tumor of Liver)

Cited by 6 publications

References 11 publications

Combined associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) followed by left trisectionectomy and Whipple operation for PNET

Combined associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) followed by left trisectionectomy and Whipple operation for PNET

Neuroendocrine tumor arising from the greater omentum treated with laparoscopic tumor resection: a case report

Liver Metastasis of Gastrointestinal Neuroendocrine Tumors: A Single Center Experience

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