Resection of isolated pancreatic metastases from pulmonary neoplasia: a systematic review

Jaén-Torrejimeno, Isabel; López-Guerra, Diego; Rojas-Holguín, Adela; De-Armas-Conde, Noelia; Blanco‐Fernández, Gerardo

doi:10.1007/s13304-022-01375-6

Cited by 4 publications

(6 citation statements)

References 28 publications

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“…Previous studies ( 32 , 33 ) have suggested that clinical symptoms of PM-SCLC and PDAC were similar including weight loss, jaundice, pain, dyspepsia and nausea, etc. The clinical symptoms of PM-SCLC were not prominent except in a few cases, while most PDAC is accompanied by clinical symptoms except for early PDAC ( 30 , 32 , 34 , 35 ).…”

Section: Discussionmentioning

confidence: 87%

“…weight loss, jaundice, pain, dyspepsia and nausea, etc. The clinical symptoms of PM-SCLC were not prominent except in a few cases, while most PDAC is accompanied by clinical symptoms except for early PDAC (30,32,34,35). In our study, the absence of clinical symptoms was discriminating variable to differentiate PPM from PDAC, there were significant differences in clinical symptoms between the two groups (P < 0.001).…”

Section: Discussionmentioning

confidence: 92%

“…It has been reported that patients with PM-SCLC are often in the advanced stage of disease, with poor general condition or systemic metastasis, and low postoperative survival rate, and surgical treatment is not recommended (13,31). Isabel et al showed that chemotherapy could be considered in the case of primary tumor synchronous PM (13,32), which was a safe and effective treatment decision that could improve survival in selected patients. Thus, in our study, we analyzed and compared the characteristics of PM-SCLC and PDAC, and aimed to establish a preoperative a noninvasive and convenient nomogram diagnostic predictive model to provide a basis for optimal treatment decisions for the subsequent surgical treatment and adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we developed three models based on clinical characteristics, radiological features and biomarkers for diagnostic prediction of PM-SCLC. We identified 3 clinical characteristics (clinical symptoms, CA199, gender) in the Previous studies (32,33) have suggested that clinical symptoms of PM-SCLC and PDAC were similar including A 69-year-old woman with PDAC, absence of clinical symptoms, CA199 positive. Axial unenhanced (A), pancreatic parenchymal (B), and portal (C) phases CT images, demonstrated a low-attenuation nodules approximately 25mm in diameter in the neck of the pancreas (black arrow).…”

Section: Discussionmentioning

confidence: 99%

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A nomogram diagnostic prediction model of pancreatic metastases of small cell lung carcinoma based on clinical characteristics, radiological features and biomarkers

Yang

et al. 2023

Front. Oncol.

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ObjectiveTo investigate clinical characteristics, radiological features and biomarkers of pancreatic metastases of small cell lung carcinoma (PM-SCLC), and establish a convenient nomogram diagnostic predictive model to differentiate PM-SCLC from pancreatic ductal adenocarcinomas (PDAC) preoperatively.MethodsA total of 299 patients with meeting the criteria (PM-SCLC n=93; PDAC n=206) from January 2016 to March 2022 were retrospectively analyzed, including 249 patients from hospital 1 (training/internal validation cohort) and 50 patients from hospital 2 (external validation cohort). We searched for meaningful clinical characteristics, radiological features and biomarkers and determined the predictors through multivariable logistic regression analysis. Three models: clinical model, CT imaging model, and combined model, were developed for the diagnosis and prediction of PM-SCLC. Nomogram was constructed based on independent predictors. The receiver operating curve was undertaken to estimate the discrimination.ResultsSix independent predictors for PM-SCLC diagnosis in multivariate logistic regression analysis, including clinical symptoms, CA199, tumor size, parenchymal atrophy, vascular involvement and enhancement type. The nomogram diagnostic predictive model based on these six independent predictors showed the best performance, achieved the AUCs of the training cohort (n = 174), internal validation cohort (n = 75) and external validation cohort (n = 50) were 0.950 (95%CI, 0.917-0.976), 0.928 (95%CI, 0.873-0.971) and 0.976 (95%CI, 0.944-1.00) respectively. The model achieved 94.50% sensitivity, 83.20% specificity, 86.80% accuracy in the training cohort and 100.00% sensitivity, 80.40% specificity, 86.70% accuracy in the internal validation cohort and 100.00% sensitivity, 88.90% specificity, 87.50% accuracy in the external validation cohort.ConclusionWe proposed a noninvasive and convenient nomogram diagnostic predictive model based on clinical characteristics, radiological features and biomarkers to preoperatively differentiate PM-SCLC from PDAC.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A nomogram diagnostic prediction model of pancreatic metastases of small cell lung carcinoma based on clinical characteristics, radiological features and biomarkers

Yang

et al. 2023

Front. Oncol.

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“…Overall, 10 cases of NSCLC and 1 case with SCLC had a median survival time of 19 months (range 6-24 months) in a meta-analysis [48]. In another recent meta-analysis with 23 patients, 34.8% of them had extra pancreatic metastases, and the mean overall survival was 17.65 months after pancreatic resection [111] (Figure 13).…”

Section: Lung Cancermentioning

confidence: 99%

Comments on and Illustrations of the EFSUMB CEUS Guidelines: Transabdominal and Endoscopic Ultrasound Features of Intrapancreatic Metastases and the Role of Multiparametric Imaging and EUS-Guided Sampling in Rare Pancreatic Tumors

Möller

Jenssen

Braden

et al. 2023

Cancers

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A definite pathologic diagnosis of intrapancreatic metastasis is crucial for the management decision, i.e., curative or palliative surgery versus chemotherapy or conservative/palliative therapy. This review focuses on the appearance of intrapancreatic metastases on native and contrast-enhanced transabdominal ultrasound and endoscopic ultrasound. Differences and similarities in relation to the primary tumor, and the differential diagnosis from pancreatic carcinoma and neuroendocrine neoplasms are described. The frequency of intrapancreatic metastases in autopsy studies and surgical resection studies will be discussed. Further emphasis is placed on endoscopic ultrasound-guided sampling to confirm the diagnosis.

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Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)

Rojas-Holguín,

Fondevila-Campo,

Sanjuanbenito

et al. 2024

Surgical Oncology

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Resection of isolated pancreatic metastases from pulmonary neoplasia: a systematic review

Cited by 4 publications

References 28 publications

A nomogram diagnostic prediction model of pancreatic metastases of small cell lung carcinoma based on clinical characteristics, radiological features and biomarkers

A nomogram diagnostic prediction model of pancreatic metastases of small cell lung carcinoma based on clinical characteristics, radiological features and biomarkers

Comments on and Illustrations of the EFSUMB CEUS Guidelines: Transabdominal and Endoscopic Ultrasound Features of Intrapancreatic Metastases and the Role of Multiparametric Imaging and EUS-Guided Sampling in Rare Pancreatic Tumors

Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)

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