Resection of ictal high frequency oscillations is associated with favorable surgical outcome in pediatric drug resistant epilepsy secondary to tuberous sclerosis complex

Fujiwara, Hisako; Leach, James; Greiner, Hansel M.; Holland‐Bouley, Katherine; Rose, Douglas F.; Arthur, Todd M.; Mangano, Francesco T.

doi:10.1016/j.eplepsyres.2016.07.005

Cited by 30 publications

(20 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the wide variability in detection methods, results using automated algorithms have been relatively consistent. Two studies reported that complete resection of brain regions exhibiting high HFO rates correlated to good outcome, without separating them into ripple and FR bands 13,82 . Higher ripple resection ratios were frequently associated with improved surgical outcome, 18,19,62,83,84,87 and all of the studies that reported significant results for ripples also reported significance for FRs.…”

Section: Relationship Between Automatically Detected Hfos and Surgicamentioning

confidence: 99%

Trends in the use of automated algorithms for the detection of high‐frequency oscillations associated with human epilepsy

2020

View full text Add to dashboard Cite

Epilepsy is one of the most common neurological disorders, affecting more than 65 million people worldwide. 1 Roughly one third of patients with epilepsy have poorly controlled seizures despite optimal treatment with medication. 2 In such cases, surgical resection of the epileptogenic zone (EZ) is an alternative and effective treatment. 3,4 Postsurgical seizure freedom depends on the accurate localization of the EZ, but there are currently no validated biomarkers of the EZ. 5,6 The present gold standard for epilepsy surgery is removal of the seizure-onset zone (SOZ), defined as the brain area where

show abstract

Section: Relationship Between Automatically Detected Hfos and Surgicamentioning

confidence: 99%

Trends in the use of automated algorithms for the detection of high‐frequency oscillations associated with human epilepsy

2020

View full text Add to dashboard Cite

show abstract

“…Kannan, Vogrin, Bailey, Maixner, and Harvey (2016) provided support for a central role of the tuberal core in seizure initiation and propagation. Other studies report that electrical activity (complete removal of areas with High Frequency Oscillations and fast ripple at ictal onset) is the most relevant data in order to obtain a good outcome, regardless of the MRI findings (Fujiwara et al, 2016).…”

Section: Surgical Treatmentmentioning

confidence: 99%

Current concepts on epilepsy management in tuberous sclerosis complex

Canevini

Curatolo

Briola

et al. 2018

American J of Med Genetics Pt C

View full text Add to dashboard Cite

Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease affecting approximately 1 in 6,000 people, and represents one of the most common genetic causes of epilepsy. Epilepsy affects 90% of the patients and appears in the first 2 years of life in the majority of them. Early onset of epilepsy in the first 12 months of life is associated with high risk of cognitive decline and neuropsychiatric problems including autism. Prenatal or early infantile diagnosis of TSC, before the onset of epilepsy, provides a unique opportunity to monitor EEG before the onset of clinical seizures, thus enabling early intervention in the process of epileptogenesis. In this review, we discuss the current status of knowledge on epileptogenesis in TSC, and present recommendations of American and European experts in the field of epilepsy.

show abstract

“…VFO in TS is likely to signal pathogenicity of the initiating area (Fujiwara et al, 2016), as is the case for FCD (Traub et al, 2001). In TS, cortical and subcortical pathology includes both the tubers themselves and also more widespread altered cortical cytoarchitecture (Marcotte et al, 2012).…”

Section: Stereo-eeg (Seeg) Phenomenology Formentioning

confidence: 99%

Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms

Traub

Moeller

Rosch

et al. 2019

Reviews in the Neurosciences

View full text Add to dashboard Cite

Infantile spasms (IS) and seizures with focal onset have different clinical expressions, even when electroencephalography (EEG) associated with IS has some degree of focality. Oddly, identical pathology (with, however, age-dependent expression) can lead to IS in one patient vs. focal seizures in another or even in the same, albeit older, patient. We therefore investigated whether the cellular mechanisms underlying seizure initiation are similar in the two instances: spasms vs. focal. We noted that in-common EEG features can include (i) a background of waves at alpha to delta frequencies; (ii) a period of flattening, lasting about a second or more – the electrodecrement (ED); and (iii) often an interval of very fast oscillations (VFO; ~70 Hz or faster) preceding, or at the beginning of, the ED. With IS, VFO temporally coincides with the motor spasm. What is different between the two conditions is this: with IS, the ED reverts to recurring slow waves, as occurring before the ED, whereas with focal seizures the ED instead evolves into an electrographic seizure, containing high-amplitude synchronized bursts, having superimposed VFO. We used in vitro data to help understand these patterns, as such data suggest cellular mechanisms for delta waves, for VFO, for seizure-related burst complexes containing VFO, and, more recently, for the ED. We propose a unifying mechanistic hypothesis – emphasizing the importance of brain pH – to explain the commonalities and differences of EEG signals in IS versus focal seizures.

show abstract

Resection of ictal high frequency oscillations is associated with favorable surgical outcome in pediatric drug resistant epilepsy secondary to tuberous sclerosis complex

Cited by 30 publications

References 19 publications

Trends in the use of automated algorithms for the detection of high‐frequency oscillations associated with human epilepsy

Trends in the use of automated algorithms for the detection of high‐frequency oscillations associated with human epilepsy

Current concepts on epilepsy management in tuberous sclerosis complex

Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms

Contact Info

Product

Resources

About