Resection of brain metastases from sarcoma

Wroński, Marek; Arbit, Ehud; Burt, Michael; Perino, Georgio; Galicich, Joseph H.; Brennan, Murray F.

doi:10.1007/bf02306371

Cited by 60 publications

(67 citation statements)

References 65 publications

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“…4,7,9,[25][26][27] These tumor types include melanoma, renal cell carcinoma, and sarcoma. Stereotactic radiosurgery is an increasingly common method for treating all types of brain metastases.…”

Section: ©Aans 2013mentioning

confidence: 99%

“…Stereotactic radiosurgery is an increasingly common method for treating all types of brain metastases. [5][6][7]26 One of the advantages of radiosurgery is the ability to deliver large amounts of highly conformal radiation in a single dose, and radiosurgery has been widely used as both monotherapy and as an adjuvant boost for the treatment of intracranial metastatic disease. Classic radioresistance (to fractionated therapy) is not a known predictor of response to radiosurgery.…”

Section: ©Aans 2013mentioning

confidence: 99%

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The impact of radiosurgery fractionation and tumor radiobiology on the local control of brain metastases

Oermann

Kress

Todd

et al. 2013

JNS

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Object. Experience with whole-brain radiation therapy for metastatic tumors in the brain has identified a subset of tumors that exhibit decreased local control with fractionated regimens and are thus termed radioresistant. With the advent of frameless radiosurgery, fractionated radiosurgery (2-5 fractions) is being used increasingly for metastatic tumors deemed too large or too close to crucial structures to be treated in a single session. The authors retrospectively reviewed metastatic brain tumors treated at 2 centers to analyze the dependency of local control rates on tumor radiobiology and dose fractionation.Methods. The medical records of 214 patients from 2 institutions with radiation-naive metastatic tumors in the brain treated with radiosurgery given either as a single dose or in 2-5 fractions were analyzed retrospectively. The authors compared the local control rates of the radiosensitive with the radioresistant tumors after either single-fraction or fractionated radiosurgery.Results. There was no difference in local tumor control rates in patients receiving single-fraction radiosurgery between radioresistant and radiosensitive tumors (p = 0.69). However, after fractionated radiosurgery, treatment for radioresistant tumors failed at a higher rate than for radiosensitive tumors with an OR of 5.37 (95% CI 3.83-6.91, p = 0.032).Conclusions. Single-fraction radiosurgery is equally effective in the treatment of radioresistant and radiosensitive metastatic tumors in the brain. However, fractionated stereotactic radiosurgery is less effective in radioresistant tumor subtypes. The authors recommend that radioresistant tumors be treated in a single fraction when possible and techniques for facilitating single-fraction treatment or dose escalation be considered for larger radioresistant lesions. (http://thejns.org/doi/abs/10.3171/2013.8.JNS122177) KEy wOrdS • brain metastases • local control • radioresistance • stereotactic radiosurgery • oncology 1131Abbreviations used in this paper: IQR = interquartile range; OS = overall survival; WBRT = whole-brain radiation therapy.

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Section: ©Aans 2013mentioning

confidence: 99%

Section: ©Aans 2013mentioning

confidence: 99%

The impact of radiosurgery fractionation and tumor radiobiology on the local control of brain metastases

Oermann

Kress

Todd

et al. 2013

JNS

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“…In fact, among 9 cases of long-term survivors with brain metastasis (5 to 11 years after diagnosis of brain metastasis) reported in the literature, 8 have solitary intra-cranial lesion. Multi-modality treatment was achieved in almost all these cases, with RT done in 8 cases, post-operatively in 6 cases and exclusively in 2 other cases [4,5,[12][13][14][15][16][17]. Our patient benefited from multi-modality treatment including complete resection, postoperative radiotherapy and chemotherapy and still alive without evidence of disease.…”

Section: Discussionmentioning

confidence: 86%

Role of post-operative radiation therapy in single brain metastasis from clear cell sarcoma in children: a case report with systemic review

Rais¹,

Benhmidou²,

Rais³

et al. 2016

JPS

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IntroductionBrain metastasis is a common oncologic problem in adults but is relatively uncommon in children with solid tumors. In fact, approximately 25-35% of all adult cancer patients with solid tumors will develop parenchymal intracranial metastasis whereas only 2.5% to 4.5% of children will do [1][2][3][4][5]. Brain metastasis of clear cell sarcoma of the kidney occurs in less than 5% of cases during the follow-up [6,7]. Because of the relative rarity of this particular entity, information regarding management and prognosis are still missing. Trough the report of

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“…reported metastasis in left cerebellar hemisphere in a 16 month old child presented with posterior fossa hemorrhage with a survival ofonly 6 days. Wroński et al 12 .described posterior fossa metastasis along with cerebral metastasis. This case is the third reported case involving the posterior fossa (cerebellum) again with bad prognosis.…”

Section: Discussionmentioning

confidence: 99%

Posterior fossa brain metastasis from primary osteogenic sarcoma: A rare entity

Ahmed

Imtiaz

Hamid

et al. 2016

Sri Lanka J. Radiol.

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Resection of brain metastases from sarcoma

Abstract: Because brain metastases from sarcoma are refractory to alternative treatment, surgical excision is indicated when feasible. Brain metastases from sarcoma are uncommon, usually occurring with or after lung metastasis. Long-term survival is possible in some patients.

Cited by 60 publications

References 65 publications

The impact of radiosurgery fractionation and tumor radiobiology on the local control of brain metastases

The impact of radiosurgery fractionation and tumor radiobiology on the local control of brain metastases

Role of post-operative radiation therapy in single brain metastasis from clear cell sarcoma in children: a case report with systemic review

Posterior fossa brain metastasis from primary osteogenic sarcoma: A rare entity

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