Resection of a Solitary Pancreatic Metastasis from Renal Cell Carcinoma with a Gallbladder Carcinoma: Report of a Case

Andoh, Hideaki; Kurokawa, Toshiaki; Yasui, Ouki; Shibata, Satoshi; Sato, Tsutomu

doi:10.1007/s00595-003-2680-6

Cited by 14 publications

(4 citation statements)

References 17 publications

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“…Immunohistochemically, primary clear cell carcinoma of the GB is strongly positive for CEA and CK7, and moderately positive for CK10, but negative for vimentin. On the other hand, metastatic RCC of the GB is positive for vimentin, but negative for CEA, CK7, and CK10 ,. Because our immunohistochemical findings were nearly consistent with the reported findings, we finally diagnosed metastatic GB tumor from RCC rather than primary clear cell carcinoma of the GB.…”

Section: Discussionmentioning

confidence: 98%

“…In our review of the English‐language literature, we found 12 reported cases of GB metastasis of RCC (summarized in Table 1). The presumed mode of GB involvement from intraperitoneal organs is usually direct invasion or peritoneal implantation, while metastases from extraperitoneal organs, such as the lung, kidney, breast, and malignant melanoma, follow a hematogenous route ,. Hematogeneous metastases to GB initially occur as small flat nodules below the mucosal layer and then they grow as a pedunculated nodule and resemble a primary GB carcinoma .…”

Section: Discussionmentioning

confidence: 99%

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Renal cell carcinoma with unusual metastasis to the gallbladder

Nojima

Cho

Yamamoto

et al. 2008

J Hepatobiliary Pancreat Surg

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Gallbladder involvement in patients with renal cell carcinoma (RCC) is extremely rare. We present a report of a 61-year-old man with a synchronous RCC metastasis to the gallbladder presenting as an intraluminal polypoid mass simulating primary gallbladder carcinoma. Enhanced abdominal computed tomography demonstrated a well-enhanced polypoid lesion in the gallbladder. Intraoperative rapid pathological examination of the gallbladder tumor showed clear cell-type cancerous cells. Microscopically, tumor cells of both the resected kidney and gallbladder had round uniform nuclei, clear cytoplasm, and well-defined cytoplasmic borders, forming alveolar patterns. Immunohistochemically, the tumor cells were negative for cytokeratin 7 (CK7) and carcinoembryonic antigen (CEA), which is usually positive in primary clear cell carcinoma of the gallbladder. Therefore, the final diagnosis was RCC with a synchronous gallbladder metastasis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma with unusual metastasis to the gallbladder

Nojima

Cho

Yamamoto

et al. 2008

J Hepatobiliary Pancreat Surg

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“…Of note, the majority of patients were asymptomatic. Some have suggested that although isolated presentations of primary RCC and primary gallbladder can occur in the same patient, the preoperative diagnosis of gallbladder metastasis should be considered in patients with a history of RCC [8,9]. As of today, specific postoperative screening for gallbladder metastasis in asymptomatic patients with a history of RCC would be inadvisable, since the number needed to screen to identify a single gallbladder metastasis would be in the thousands; however, when cross-sectional imaging is performed pre- or post-operatively, a “closer look” at the gallbladder is reasonable.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma with metastases to the gallbladder: Four cases from the National Cancer Institute (NCI) and review of the literature

Chung

Srinivasan

Linehan

et al. 2012

Urologic Oncology: Seminars and Original Investigations

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Objective We evaluate presentation and outcome of patients with metastatic RCC to the gallbladder from our institution and published literature. Methods Patients with a history of gallbladder metastasis from RCC were selected from our institution’s prospective database. A systematic PubMed search was performed to identify articles describing patients with metastatic RCC to the gallbladder. The final cohort included 33 patients: 4 from our institution and 29 from 28 previously published cases. Survival analysis was conducted using LogRank Kaplan-Meier analysis. Results Median patient age was 63 years and the majority of patients were male. Most patients were asymptomatic and diagnosed with gallbladder metastasis on imaging performed for surveillance or staging. The median time to gallbladder metastasis following nephrectomy was 4 years. Metastasis to the gallbladder occurred both synchronously (33%) and metachronously (67%). Of the patients with available histology, all had clear cell RCC (n=28). Of all patients, 13 (39%) only had metastasis to the gallbladder, while 20 (61%) had additional sites of metastasis. The most common sites of additional metastasis were contralateral kidney (30%), pancreas (21%), lung (18%), adrenal (18%), and lymph nodes (9%). All patients underwent cholecystectomy. At a median follow up time of 1.5 years after cholecystectomy, 54% of patients had no evidence of disease, 14% were alive with metastasis, 23% had died from metastatic RCC, and 9% died from causes unrelated to their cancer. Conclusion Gallbladder metastasis from RCC is a rare event that may occur synchronously or metachronously with most patients being asymptomatic. Clear cell carcinoma appears to be the primary pathology associated with gallbladder metastasis. High rates of bilateral RCC and pancreatic metastasis suggest novel associations in patients with RCC and gallbladder metastasis.

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“…Frequent sites of metastasis include the lung parenchyma (50% to 60%), [2] bone (30% to 40%), [3] liver (30% to 40%), and brain (5%) [4]. Other rare sites of metastasis include pancreas [5,6], adrenal gland [7,8], parotid gland [9], maxilla, pharynx etc. Even with early-stage disease, late metastases can occur after complete resection.…”

Section: Introductionmentioning

confidence: 99%