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Thyavihally, Y.; Mahantshetty, Umesh; Chamarajanagar, Ravichand S; Raibhattanavar, Srinivas G; Tongaonkar, Hemant

doi:10.1186/1477-7819-3-48

Cited by 82 publications

(31 citation statements)

References 25 publications

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“…Metastatic renal cell carcinoma has a high mortality with a 5-year survival rate of 11.7% [4] and a median survival of 27 months [11]. This patient has reached 9 years of disease-free survival since presenting with an ocular metastasis, remaining in total remission 13 years after his initial treatment with nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Melanoma Mimicker: A Case of Metastatic Clear-Cell Renal Cell Carcinoma

Komanski¹,

Rubino²,

Meyer³

et al. 2017

Ocul Oncol Pathol

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Choroidal melanoma is the most common primary intraocular malignancy, yet metastatic disease remains the most common malignancy of the eye. Differentiating these entities is essential as treatment, systemic associations, and prognosis vary dramatically between the two. Established diagnostic criteria are accurate for the diagnosis of uveal melanoma. Yet, metastatic disease may be misdiagnosed as a uveal melanoma in rare cases. We report a case of metastatic clear-cell renal cell carcinoma masquerading as uveal melanoma. A 73-year-old Caucasian man with a history of renal cell carcinoma presented with a 15 × 12 × 7 mm homogenous, pigmented, and acoustically hollow mass without hemorrhage or exudation. The patient was initially treated with plaque radiotherapy with good tumor regression. However, the patient developed pain and vision loss due to total exudative retinal detachment. Subsequent enucleation allowed histopathologic confirmation of clear-cell renal cell carcinoma. Nine years following enucleation, the patient remains in complete remission without evidence of other systemic metastases. Renal cell carcinoma should be considered when evaluating patients with probable uveal melanoma. Delayed-onset ocular metastasis from renal cell carcinoma exhibits an atypical clinical course with the possibility of durable remission following enucleation.

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Section: Discussionmentioning

confidence: 99%

Choroidal Melanoma Mimicker: A Case of Metastatic Clear-Cell Renal Cell Carcinoma

Komanski¹,

Rubino²,

Meyer³

et al. 2017

Ocul Oncol Pathol

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“…As far as management of single renal cell carcinoma metastases is concerned, as reported in 2005 by the Tongaonkar group [4], complete resection either by excision or radiotherapy is justified and can contribute to long-term survival.…”

Section: Discussionmentioning

confidence: 99%

“…Mean survival time after a single metastasectomy is 45 months [4]. The longer the disease-free interval, the longer the survival, and synchronous metastases seems to correlate to a worse prognosis than metachronous metastases.…”

Section: Discussionmentioning

confidence: 99%

“…The site of mestases can be related to the survival: patients with lung and bone metastases have a better prognosis (median survival 62 months) than those with liver and brain metastases (median survival 22 months), probably because of differences in the feasibility of a radical excision [4]. …”

Section: Discussionmentioning

confidence: 99%

“…The RCC usually metastasizes via the haematogenous and lymphatic systems, involving the lung (50–60%), lymph node (40–60%), liver (30–40%), bone (30–40%), brain (5%), bowel (4%), pancreas (1%) and rarely the adrenal gland, parotid gland and pharynx [4]. A case of RCC ocular metastases has also been reported [5].…”

Section: Introductionmentioning

confidence: 99%

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ecancermedicalscience

Melegari

Albo

Rocco

et al.

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Introduction:adrenal gland, parotid gland, pharynx, eye and bladder are rare localizations of metastases of renal cell carcinoma (RCC). We report a case of metachronous RCC metastases to the bladder in a patient with a medical history of transitional cell carcinoma (TCC) of the bladder.Materials and methods:a case study and review of the relevant literature are presented.Results:during a follow-up cystoscopy examination following treatment of TCC, a single 5-mm lesion was detected and endoscopically resected. The histology of the resected sample was confirmed to be RCC, comparable to a primary kidney cancer and not recurrent TCC.Conclusion:the patient had a probability of metastases three years after nephrectomy of 62.9%. Survival rates following single metastasectomy are 60% and 38% at three and five years, respectively; metachronous diagnosis has a better prognosis than synchronous. During RCC follow-up, each lesion should be considered as a possible metastasis of RCC.

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