Resected adenocarcinoma of the pancreas—616 patients: results, outcomes, and prognostic indicators

Sohn, Taylor A.; Yeo, Charles J.; Cameron, John L.; Koniaris, Leonidas G.; Kaushal, Sunjay; Abrams, Ross A.; Sauter, Patricia K.; Coleman, JoAnn; Hruban, Ralph H.; Lillemoe, Keith D.

doi:10.1016/s1091-255x(00)80105-5

Cited by 1,368 publications

(943 citation statements)

References 38 publications

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“…There are only few substantial data reporting clinical significant prognostic markers for pancreatic cancer patients. Sohn et al (2000) showed by multivariate analysis that negative resection margins, tumour size and differentiation were important independent prognostic indicators. Similarly, Geer and Brennan (1993) node involvement in both univariate and multivariate analyses.…”

Section: Discussionmentioning

confidence: 99%

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

et al. 2005

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Pancreatic cancer is one of the most aggressive gastrointestinal cancer with less than 10% long-term survivors. The apoptotic pathway deregulation is a postulated mechanism of carcinogenesis of this tumour. The present study investigated the prognostic role of apoptosis and apoptosis-involved proteins in a series of surgically resected pancreatic cancer patients. All patients affected by pancreatic adenocarcinoma and treated with surgical resection from 1988 to 2003 were considered for the study. Patients' clinical data and pathological tumour features were recorded. Survivin and Cox-2 expression were evaluated by immunohistochemical staining. Apoptotic cells were identified using the TUNEL method. Tumour specimen of 67 resected patients was included in the study. By univariate analysis, survival was influenced by Survivin overexpression. The nuclear Survivin overexpression was associated with better prognosis (P ¼ 0.0009), while its cytoplasmic overexpression resulted a negative prognostic factor (P ¼ 0.0127). Also, the apoptotic index was a statistically significant prognostic factor in a univariate model (P ¼ 0.0142). By a multivariate Cox regression analysis, both the nuclear (P ¼ 0.002) and cytoplasmic (P ¼ 0.040) Survivin overexpression maintained the prognostic statistical value. This is the first study reporting a statistical significant prognostic relevance of nuclear and cytoplasmic Survivin overexpression in pancreatic cancer. In particular, patients with high nuclear Survivin staining showed a longer survival, whereas patients with high cytoplasmic Survivin staining had a shorter overall survival.

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Section: Discussionmentioning

confidence: 99%

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

et al. 2005

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“…Clinicopathologic parameters, such as positive lymph nodes, positive margins and histological type, were well-known as prognostic factors for surgical outcome (Geer and Brennan, 1993;Sohn et al, 2000). Recently, numerous genetic and epigenetic alterations were revealed to occur during the development of pancreatic adenocarcinoma and some molecules were reported to be useful for the prediction of prognosis (Infante et al, 2007;Kahlert et al, 2009;Manuyakorn et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity

et al. 2011

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“…Pancreaticoduodenectomy is a procedure performed in varying numbers at many academic institutions. Originally associated with significant perioperative morbidity and mortality, multiple studies have now shown that this operation can be performed quite safely at high volume institutions that develop a particular expertise (16). Critical pathways have been cited as one of the key tools used to achieve consistently excellent outcomes as these institutions.…”

Section: Introductionmentioning

confidence: 99%

Initiation of a Critical Pathway for Pancreaticoduodenectomy at an Academic Institution—the First Step in Multidisciplinary Team Building

Kennedy¹,

Rosato²,

Sauter³

et al. 2007

Journal of the American College of Surgeons

197

159

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Resected adenocarcinoma of the pancreas—616 patients: results, outcomes, and prognostic indicators

Cited by 1,368 publications

References 38 publications

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity

Initiation of a Critical Pathway for Pancreaticoduodenectomy at an Academic Institution—the First Step in Multidisciplinary Team Building

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