Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity

Akita, Hirofumi; Nagano, Hiroaki; Takeda, Yutaka; Eguchi, Hidetoshi; Wada, Hiroshi; Kobayashi, Shogo; Marubashi, Shigeru; Tanemura, Masahiro; Takahashi, Hidenori; Ohigashi, Hajime; Tomita, Yoshihiro; Ishikawa, Osamu; Mori, Masaki; Doki, Yuichiro

doi:10.1038/onc.2011.59

Cited by 31 publications

(27 citation statements)

References 49 publications

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“…In these contexts, it would also be interesting to explore the prognostic significance of the various biogenetic factors known to be associated with tumor progression (eg, SMAD4/DPC4 and EpCAM), gemcitabine resistance (eg, human equilibrative nucleoside transporter-1 and RRM1), and radioresponsiveness (eg, REG 4). [48][49][50][51][52][53][54][55] Further investigations regarding these factors as potential prognostic factors will contribute to improved prognostic predictions and deeper insights into the biogenetic mechanisms associated with treatment responsiveness in the setting of preoperative CRT strategy.…”

Section: Discussionmentioning

confidence: 99%

Perineural Invasion and Lymph Node Involvement as Indicators of Surgical Outcome and Pattern of Recurrence in the Setting of Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable Pancreatic Cancer

Takahashi¹,

Ohigashi²,

Ishikawa³

et al. 2012

Annals of Surgery

112

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Section: Discussionmentioning

confidence: 99%

Perineural Invasion and Lymph Node Involvement as Indicators of Surgical Outcome and Pattern of Recurrence in the Setting of Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable Pancreatic Cancer

Takahashi¹,

Ohigashi²,

Ishikawa³

et al. 2012

Annals of Surgery

112

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“…43 However, in some entities such as pancreatic and gastrointestinal cancers EpCAM overexpression rather correlates with better prognosis. 44 The molecular basis for this discrepancy is as yet unknown.…”

Section: General Facts On Epcammentioning

confidence: 99%

EpCAM and its potential role in tumor-initiating cells

Imrich

Hachmeister²,

Gires³

2012

Cell Adhesion & Migration

167

132

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These authors contributed equally to this work. Keywords: EpCAM, tumor inducing cells, cancer therapyEpithelial cell adhesion molecule EpCAM is expressed on a subset of normal epithelia and overexpressed on malignant cells from a variety of different tumor entities. This overexpression is even more pronounced on so-called tumorinitiating cells (TICs) of many carcinomas. Taking this rather ubiquitous expression of EpCAM in carcinomas and TICs into account, the question arises how EpCAM can serve as a reliable marker for tumor-initiating cells and what might be the advantage for TICs to express this molecule. Furthermore, several approaches for therapeutic strategies targeting exclusively EpCAM on cancer cells were undertaken over the past decades and have recently been transferred to pre-clinical attempts to eradicate TICs. In the present review, we will depict potential functions of EpCAM in tumor cells with a special focus on TICs and therapeutic implications.

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“…A recent report links pro-oncogenic effects of EpCAM to sequential proteolysis that releases a soluble intracellular fragment that enhances TCF/LEF1-dependent signaling, thereby promoting expression of downstream cell cycle regulators, including c-Myc (3). In contrast, in other tumors EpCAM appears to suppress cancer progression (2,4). Mechanisms responsible for the divergent activities of EpCAM in different contexts have not yet been elucidated.…”

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confidence: 99%

Epithelial Cell Adhesion Molecule (EpCAM) Regulates Claudin Dynamics and Tight Junctions

Mannan

et al. 2013

Journal of Biological Chemistry

108

135

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Background: EpCAM is important for intestinal epithelial integrity and is also involved in tumorigenesis. Results: EpCAM interacts with claudin-7 and claudin-1, protects them from lysosomal degradation, and alters their intercellular distribution. Conclusion: EpCAM modifies tight junction composition and function by regulating amounts and locations of claudins. Significance: Effects of EpCAM on epithelial physiology and tumorigenicity may be mediated via modulation of claudins and tight junctions.

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Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity

Cited by 31 publications

References 49 publications

Perineural Invasion and Lymph Node Involvement as Indicators of Surgical Outcome and Pattern of Recurrence in the Setting of Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable Pancreatic Cancer

Perineural Invasion and Lymph Node Involvement as Indicators of Surgical Outcome and Pattern of Recurrence in the Setting of Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable Pancreatic Cancer

EpCAM and its potential role in tumor-initiating cells

Epithelial Cell Adhesion Molecule (EpCAM) Regulates Claudin Dynamics and Tight Junctions

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