Research progresses of molecular mechanism of pyroptosis and its related diseases

Gong, Weihua; Shi, Ying; Ren, Jingjing

doi:10.1016/j.imbio.2019.11.019

Cited by 67 publications

(69 citation statements)

References 47 publications

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“…Pyroptosis comprises two pathways; canonical and non-canonical pathways. The canonical pathway is activated in non-infectious inflammation-associated diseases [30]. Several studies…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α

Huang

Tan

Zhuo

et al. 2020

Aging

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Among central nervous system (CNS) diseases, cerebral ischemic stroke is the most common cause of death and disability [1]. This condition has been successfully treated with tissue plasminogen activator (tPA) therapy. However, the reperfusion process may result in serious brain tissue damage [2], and has been an intractable challenge in stroke treatment. It is, therefore, crucial to elucidate the latent mechanisms of cerebral I/R injury. Cerebral I/R insult is often accompanied with inflammation [3]. In addition, cerebral I/R injury causes different subtypes of programmed cell death, including

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“…Pyroptosis comprises two pathways; canonical and non-canonical pathways. The canonical pathway is activated in non-infectious inflammation-associated diseases [30]. Several studies…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α

Huang

Tan

Zhuo

et al. 2020

Aging

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“…In a peritoneal Salmonella Typhimurium infection model, CD11d −/− mice were characterized by diminished peritoneal infiltration of leukocytes and accordingly elevated bacterial loads [224]. Ex vivo analysis confirmed attenuated phagocytic activity of CD11d −/− macrophages, accompanied by increased cell death in the course of the inflammatory response, termed pyroptosis [225].…”

Section: Bacterial Infectionsmentioning

confidence: 92%

β2 Integrins—Multi-Functional Leukocyte Receptors in Health and Disease

Bednarczyk

Stege

Grabbe

et al. 2020

IJMS

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β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d) and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α subunit defines the individual functional properties of the corresponding β2 integrin, but all β2 integrins show functional overlap. They mediate adhesion to other cells and to components of the extracellular matrix (ECM), orchestrate uptake of extracellular material like complement-opsonized pathogens, control cytoskeletal organization, and modulate cell signaling. This review aims to delineate the tremendous role of β2 integrins for immune functions as exemplified by the phenotype of LAD-I (leukocyte adhesion deficiency 1) patients that suffer from strong recurrent infections. These immune defects have been largely attributed to impaired migratory and phagocytic properties of polymorphonuclear granulocytes. The molecular base for this inherited disease is a functional impairment of β2 integrins due to mutations within the CD18 gene. LAD-I patients are also predisposed for autoimmune diseases. In agreement, polymorphisms within the CD11b gene have been associated with autoimmunity. Consequently, β2 integrins have received growing interest as targets in the treatment of autoimmune diseases. Moreover, β2 integrin activity on leukocytes has been implicated in tumor development.

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“…Pyroptosis is a type of programmed cell death involving breakage of plasma-membrane, resulting in the release of proinflammatory intracellular contents [ 20 ]. Caspases 1, 4, 5, and 11 play an important role in pyroptosis [ 21 ]. Three different pathways for pyroptosis have been proposed so far( Figure 2 b): the caspase 1 dependent pathway also called the canonical inflammasome pathway, the noncanonical inflammasome pathway consisting of caspases 4, 5, and 11, and most recently proposed the caspase 3 dependent pathway [ 21 , 22 ].In the canonical inflammasome pathway, intracellular pattern recognition receptors (PRR) receive signal stimulation in the form of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs).…”

Section: Distinct Cell Death Mechanismsmentioning

confidence: 99%

“…Caspases 1, 4, 5, and 11 play an important role in pyroptosis [ 21 ]. Three different pathways for pyroptosis have been proposed so far( Figure 2 b): the caspase 1 dependent pathway also called the canonical inflammasome pathway, the noncanonical inflammasome pathway consisting of caspases 4, 5, and 11, and most recently proposed the caspase 3 dependent pathway [ 21 , 22 ].In the canonical inflammasome pathway, intracellular pattern recognition receptors (PRR) receive signal stimulation in the form of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). Subsequently, the inflammatory body is assembled and an intracellular macromolecular protein complex is produced, leading to the activation of caspase 1, which thereby causes secretion ofIL-1β and IL-18 on one hand, and cleavage of gasdermin-D (GSDMD) to generate two types of ends–reactive amino (N) and carboxyl (C).…”

Section: Distinct Cell Death Mechanismsmentioning

confidence: 99%

“…Subsequently, the inflammatory body is assembled and an intracellular macromolecular protein complex is produced, leading to the activation of caspase 1, which thereby causes secretion ofIL-1β and IL-18 on one hand, and cleavage of gasdermin-D (GSDMD) to generate two types of ends–reactive amino (N) and carboxyl (C). All this leads to the destruction of cellular structure and subsequent cell lysis and cell death [ 21 ].…”

Section: Distinct Cell Death Mechanismsmentioning

confidence: 99%

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Pseudomonas Aeruginosa Induced Cell Death in Acute Lung Injury and Acute Respiratory Distress Syndrome

Deshpande

Zou

2020

IJMS

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Pseudomonas aeruginosa is an important opportunistic pathogen responsible for the cause of acute lung injury and acute respiratory distress syndrome. P. aeruginosa isthe leading species isolated from patients with nosocomial infection and is detected in almost all the patients with long term ventilation in critical care units. P. aeruginosa infection is also the leading cause of deleterious chronic lung infections in patients suffering from cystic fibrosis as well as the major reason for morbidity in people with chronic obstructive pulmonary disease. P. aeruginosa infections are linked to diseases with high mortality rates and are challenging for treatment, for which no effective remedies have been developed. Massive lung epithelial cell death is a hallmark of severe acute lung injury and acute respiratory distress syndrome caused by P. aeruginosa infection. Lung epithelial cell death poses serious challenges to air barrier and structural integrity that may lead to edema, cytokine secretion, inflammatory infiltration, and hypoxia. Here we review different types of cell death caused by P. aeruginosa serving as a starting point for the diseases it is responsible for causing. We also review the different mechanisms of cell death and potential therapeutics in countering the serious challenges presented by this deadly bacterium.

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Research progresses of molecular mechanism of pyroptosis and its related diseases

Cited by 67 publications

References 47 publications

Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α

Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α

β2 Integrins—Multi-Functional Leukocyte Receptors in Health and Disease

Pseudomonas Aeruginosa Induced Cell Death in Acute Lung Injury and Acute Respiratory Distress Syndrome

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