Research progress on the mechanism of interleukin-1β on epiphyseal plate chondrocytes

Tong, Ziyuan; Xu, Yang; Li, Jianjun

doi:10.1186/s40001-022-00893-8

Cited by 4 publications

(4 citation statements)

References 109 publications

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“…The epiphyseal plate, also known as the growth plate, is a hyaline cartilage plate that lies between the epiphyses and metaphyses and is where the growth of long bone, the accumulation of bone trabeculae, and the formation of its structure take place [12,16,28,34]. Injury to the epiphysis may result in a series of potential problems, such as joint deformities, premature closure of the epiphyseal plate and traumatic arthritis [4,9,24,34]. Osteogenesis of the epiphysis can be afected by mechanical stress [7,27,39], and the distal femur growth plate may inluence trochlear morphology in terms of abnormal stress due to poor patellar trochlear engagement.…”

Section: Introductionmentioning

confidence: 99%

“…The epiphyseal plate plays a key role in bone growth [14,23]. The epiphyseal plate, also known as the growth plate, is a hyaline cartilage plate that lies between the epiphyses and metaphyses and is where the growth of long bone, the accumulation of bone trabeculae, and the formation of its structure take place [12,16,28,34]. Injury to the epiphysis may result in a series of potential problems, such as joint deformities, premature closure of the epiphyseal plate and traumatic arthritis [4,9,24,34].…”

Section: Introductionmentioning

confidence: 99%

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Patients with trochlear dysplasia have dysplastic medial femoral epiphyseal plates

Kong,

Kang,

Niu

et al. 2023

Knee surg. sports traumatol. arthrosc.

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Purpose To investigate the growth of the epiphyseal plate in patients with trochlea dysplasia using a 3D computed tomography (CT)-based reconstruction of the bony structure of the distal femur. The epiphysis plate was divided into a medial part and a lateral part to compare their diferences in patients with trochlear dysplasia. Methods This retrospective study included 50 patients with trochlea dysplasia in the study group and 50 age-and sexmatched patients in the control group. Based on the CT images, MIMICS was used to reconstruct the bony structure of the distal femur. Measurements included the surface area and volume of the growth plate (both medial and lateral), the surface area and capacity of the proximal trochlea, trochlea-physis distance (TPD) (both medial and lateral), and height of the medial and lateral condyle. ResultsThe surface area of the medial epiphyseal plate (1339.8 ± 202.4 mm 2 vs. 1596.6 ± 171.8 mm 2 ), medial TPD (4.9 ± 2.8 mm vs. 10.6 ± 3.0 mm), height of the medial condyle (1.1 ± 2.5 mm vs. 4.9 ± 1.3 mm), and capacity of the proximal trochlear groove (821.7 ± 230.9 mm 3 vs. 1520.0 ± 498.0 mm 3 ) was signiicantly smaller in the study group than in the control group. A signiicant positive correlation was found among the area of the medial epiphyseal plate, the medial TPD, the height of the medial condyle and the capacity of the proximal trochlear groove (r = 0.502-0.638). ConclusionThe medial epiphyseal plate was dysplastic in patients with trochlea dysplasia. There is a signiicant positive correlation between the surface area of the medial epiphyseal plate, medial TPD, height of the medial condyle and capacity of the proximal trochlear groove, which can be used to evaluate the developmental stage of the trochlea in clinical practice and to guide targeted treatment of trochlear dysplasia. Level of evidence III.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Patients with trochlear dysplasia have dysplastic medial femoral epiphyseal plates

Kong,

Kang,

Niu

et al. 2023

Knee surg. sports traumatol. arthrosc.

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“…17 Studies have shown that IL-1β levels are significantly elevated which can cause the chondrocyte damage by promoting the degradation of extracellular matrix or by increasing oxidative stress. 18 Pichler et al found that IL-1β promotes the proliferation of CPCs at the growth plate injury site, while mechanical loading inhibits CPCs proliferation. In vitro, the inflammatory environment during the early stage of growth plate injury suppresses osteogenesis and chondrogenesis of CPCs and significantly promotes their hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

et al. 2023

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The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has emerged as a promising therapeutic approach for achieving tissue regeneration through the use of functional biological materials, seed cells and biological factors, and it is now widely applied to the regeneration of bone and cartilage. However, due to the unique structure and function of growth plate cartilage, distinct strategies are required for effective regeneration. Thus, this review provides an overview of current research on the application of tissue engineering to promote growth plate regeneration. It aims to elucidates the underlying mechanisms by which tissue engineering promotes growth plate regeneration and to provide novel insights and therapeutic strategies for future research on the regeneration of growth plate.

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“…Longitudinal bone growth occurs in the epiphyseal growth plates, wherein chondrocytes undergo a slow division process and then rapidly proliferate and enlarge [ 1 , 2 ]. The growth process is tightly regulated by numerous factors [ 3 ], including genes [ 4 ], systemic factors [ 5 ], local factors [ 6 ], and mechanical loading [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Micromechanical Loading Studies in Ex Vivo Cultured Embryonic Rat Bones Enabled by a Newly Developed Portable Loading Device

Zhang,

Zaman,

Nava

et al. 2023

Ann Biomed Eng

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Mechanical loading has been described as having the potential to affect bone growth. In order to experimentally study the potential clinical applications of mechanical loading as a novel treatment to locally modulate bone growth, there is a need to develop a portable mechanical loading device enabling studies in small bones. Existing devices are bulky and challenging to transfer within and between laboratories and animal facilities, and they do not offer user-friendly mechanical testing across both ex vivo cultured small bones and in vivo animal models. To address this, we developed a portable loading device comprised of a linear actuator fixed within a stainless-steel frame equipped with suitable structures and interfaces. The actuator, along with the supplied control system, can achieve high-precision force control within the desired force and frequency range, allowing various load application scenarios. To validate the functionality of this new device, proof-of-concept studies were performed in ex vivo cultured rat bones of varying sizes. First, very small fetal metatarsal bones were microdissected and exposed to 0.4 N loading applied at 0.77 Hz for 30 s. When bone lengths were measured after 5 days in culture, loaded bones had grown less than unloaded controls (p < 0.05). Next, fetal rat femur bones were periodically exposed to 0.4 N loading at 0.77 Hz while being cultured ex vivo for 12 days. Interestingly, this loading regimen had the opposite effect on bone growth, i.e., loaded femur bones grew significantly more than unloaded controls (p < 0.001). These findings suggest that complex relationships between longitudinal bone growth and mechanical loading can be determined using this device. We conclude that our new portable mechanical loading device allows experimental studies in small bones of varying sizes, which may facilitate further preclinical studies exploring the potential clinical applications of mechanical loading.

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Research progress on the mechanism of interleukin-1β on epiphyseal plate chondrocytes

Cited by 4 publications

References 109 publications

Patients with trochlear dysplasia have dysplastic medial femoral epiphyseal plates

Patients with trochlear dysplasia have dysplastic medial femoral epiphyseal plates

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

Micromechanical Loading Studies in Ex Vivo Cultured Embryonic Rat Bones Enabled by a Newly Developed Portable Loading Device

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