Research progress on the biomedical uses of graphene and its derivatives

Liu, Yang; Ding, Jing; Wang, Qi‐Qi; Wen, Meiling; Tang, Tingting; Liu, Yong; Yuan, Rong; Li, Yongfeng; Liu, Anmin

doi:10.1016/s1872-5805(21)60073-2

Cited by 17 publications

(6 citation statements)

References 90 publications

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“…EPD-GO coatings on Mg did not produce any harmful effects on the biocompatibility of the samples, while EPD-GO-W coatings improved it by 2× as compared to bare Mg sample. These results are well validated by the previous literature, with GO coatings supporting the initial attachment, proliferation, growth, and no genotoxicity of cells [ 22 , 42 , 43 , 44 ]. Hence, EPD-GO coatings can be used for implants and other future applications where we need corrosion protection for a specific length of time.…”

Section: Resultssupporting

confidence: 87%

“…Graphene, a two-dimensional (2D) material, exhibits a honeycomb structure made up of a single layer of carbon atoms. It has been extensively explored owing to its bio-stability, non-toxicity, massive external surface area, impressive mechanical properties, and anti-corrosion properties [ 20 , 21 , 22 , 23 , 24 , 25 ]. Owing to functional groups such as hydroxyl, epoxide, carboxyl and carbonyl, graphene derivatives such as graphene oxide (GO) have better capability to disperse in water to form steady suspension [ 26 ], while the coating of these materials can be crafted by electrophoretic deposition (EPD), chemical vapor deposition (CVD), anodic oxidation, and physical vapor deposition (PVD) [ 27 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Role of Solvent Used in Development of Graphene Oxide Coating on AZ31B Magnesium Alloy: Corrosion Behavior and Biocompatibility Analysis

et al. 2022

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Clinical applications of bio-absorbable magnesium (Mg) and its alloys can be enhanced by increasing their corrosion resistance, using surface modification and functionality. In this study, we synthesized graphene oxide (GO) through improved Hummers’ method and deposited it on biodegradable AZ31B Mg alloy for further characterization. Different suspensions of GO were prepared in various solvents, like deionized water, ethanol, and acetone by ultra-sonication. Electrophoretic deposition (EPD) was used to develop GO coatings on AZ31B Mg using different GO suspensions. Effect of various solvents on corrosion behavior, as well as in vitro biocompatibility, was studied. The optimized EPD parameters were 3 volts and 90 s for coating. Different characterization techniques were used to study GO and prepared coatings. Atomic force microscopy found that the average thickness of GO was ~1 nm. Electrochemical behavior of coatings was studied through electrochemical impedance spectroscopy (EIS) and Tafel analysis in Ringer’s lactate solution. Tafel analysis revealed that GO coatings deposited by GO water suspension increased corrosion protection efficiency of AZ31B Mg alloy by ~94%. After 72 h incubation in MC3T3-E1 osteoblast cells extract, in vitro analysis was performed to determine the cell viability and biocompatibility of the GO- coated and bare Mg samples. GO coatings deposited by GO water suspension demonstrated ~2× cell viability, as well as nontoxicity and better biocompatibility compared to the bare and other GO-coated Mg samples.

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Section: Resultssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Role of Solvent Used in Development of Graphene Oxide Coating on AZ31B Magnesium Alloy: Corrosion Behavior and Biocompatibility Analysis

et al. 2022

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“…Graphene is a candidate for biomedical applications due to its low toxicity, good biocompatibility, and excellent physical, chemical, and mechanical properties, making it suitable for application in drug delivery, disease diagnosis, gene sequencing, detection of biological cells, antibacterial applications, cancer therapy, PTT, photodynamic therapy (PDT), tissue engineering, and biosensing and imaging (Gurunathan & Kim, 2016; Liu et al, 2021). Due to the wide range of potential applications of graphene and its derivatives in the field of biomedicine, its toxicity to living organisms has attracted increasing attention (Figure 6A, Cluster 1).…”

Section: Discussionmentioning

confidence: 99%

“…Its efficient fluorescence quenching ability and unique electronic properties enable it to be used in the development of biosensors, biological imaging, disease diagnosis, and molecular therapy. At the same time, it can be used to diagnose, monitor, and treat infected wounds, which represents a major contribution to reducing wound infections and saving lives (Liu et al, 2021). As for its mechanical properties, graphene and its derivatives are suitable for structural reinforcement of biocompatible films, antimicrobial hydrogels, and other scaffold materials commonly used in tissue engineering to facilitate cell regeneration and reduce the possibility of scar formation (Sanchez et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Trends and prospects in graphene and its derivatives toxicity research: A bibliometric analysis

Liu

Wang

et al. 2022

J of Applied Toxicology

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The purpose of this paper is to explore the current research status, hot topics, and future prospects in the field of graphene and its derivatives toxicity. In the article, the Web of Science Core Collection database was used as the data source, and the Cite-Space and VOSviewer were used to conduct a visual analysis of the last 10 years of research on graphene and its derivatives toxicity. A total of 8573 articles were included, and we analyzed the literature characteristics of the research results in the field of graphene and its derivatives toxicity, as well as the distribution of authors and co-cited authors; the distribution of countries and institutions; the situation of co-cited references; and the distribution of journals and categories. The most prolific countries, institutions, journals, and authors are China, the Chinese Academy of Sciences, RSC Advances, and Wang, Dayong, respectively. The co-cited author with the most citations was Akhavan, Omid. The five research hotspot keywords in the field of graphene and its derivatives toxicity were "nanomaterials," "exposure," "biocompatibility," "adsorption," and "detection." Frontier topics were "facile synthesis," "antibacterial activity," and "carbon dots." Our study provides perspectives for the study of graphene and its derivatives toxicity and yields valuable information and suggestions for the development of graphene and its derivatives toxicity research in the future.

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“…Graphene is a 2D material with exceptional electrical, thermal, and mechanical characteristics, along with good energy absorption properties [97,98]. Thus, explorations have focused on evaluating self-healing graphene-based materials.…”

Section: Wearable Sensorsmentioning

confidence: 99%

Self-Healing MXene- and Graphene-Based Composites: Properties and Applications

et al. 2023

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Today, self-healing graphene- and MXene-based composites have attracted researchers due to the increase in durability as well as the cost reduction in long-time applications. Different studies have focused on designing novel self-healing graphene- and MXene-based composites with enhanced sensitivity, stretchability, and flexibility as well as improved electrical conductivity, healing efficacy, mechanical properties, and energy conversion efficacy. These composites with self-healing properties can be employed in the field of wearable sensors, supercapacitors, anticorrosive coatings, electromagnetic interference shielding, electronic-skin, soft robotics, etc. However, it appears that more explorations are still needed to achieve composites with excellent arbitrary shape adaptability, suitable adhesiveness, ideal durability, high stretchability, immediate self-healing responsibility, and outstanding electromagnetic features. Besides, optimizing reaction/synthesis conditions and finding suitable strategies for functionalization/modification are crucial aspects that should be comprehensively investigated. MXenes and graphene exhibited superior electrochemical properties with abundant surface terminations and great surface area, which are important to evolve biomedical and sensing applications. However, flexibility and stretchability are important criteria that need to be improved for their future applications. Herein, the most recent advancements pertaining to the applications and properties of self-healing graphene- and MXene-based composites are deliberated, focusing on crucial challenges and future perspectives.

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Research progress on the biomedical uses of graphene and its derivatives

Cited by 17 publications

References 90 publications

Role of Solvent Used in Development of Graphene Oxide Coating on AZ31B Magnesium Alloy: Corrosion Behavior and Biocompatibility Analysis

Role of Solvent Used in Development of Graphene Oxide Coating on AZ31B Magnesium Alloy: Corrosion Behavior and Biocompatibility Analysis

Trends and prospects in graphene and its derivatives toxicity research: A bibliometric analysis

Self-Healing MXene- and Graphene-Based Composites: Properties and Applications

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