Research Progress on the Antiemetic Effect of Traditional Chinese Medicine Against Chemotherapy-Induced Nausea and Vomiting: A Review

Zhao, Yaozhong; Dai, Yongzhao; Nie, Ke

doi:10.3389/fphar.2021.790784

Cited by 7 publications

(2 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of nausea did not differ signi cantly whether low frequency electrical acupoint stimulation is applied or not at the acute stage. Traditional Chinese medicine can deliver de nite e cacy for CINV, including acupuncture, acupoint injection, acupoint paste, acupoint massage, and moxibustion 13 . All these therapies can relieve the gastrointestinal reactions after chemotherapy 14 .…”

Section: Discussionmentioning

confidence: 99%

Effect of low-frequency electrical acupoint stimulation on nausea and vomiting in NSCLC patients receiving highly emetogenic regimens

Zhang

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose: To assess the efficacy and tolerability of low-frequency electrical acupoint stimulation plus standard antiemetics following highly emetogenic chemotherapy in patients with non-small cell lung cancer (NSCLC). Methods: NSCLC patients who received highly emetogenic chemotherapy were randomized into control and observation groups by random number table. Patients in the observation group received the triple antiemetic regime plus low-frequency electrical acupoint stimulation (since the day of chemotherapy for 5 days consecutively). Meanwhile, those in the observation group only received the triple antiemetic regime. The severity of nausea and vomiting episodes were recorded on a daily basis. On the sixth day after chemotherapy, the patients were scored by the Functional Living Index Emesis (FLIE) questionnaire. The complete response rate of vomiting, incidence of nausea, severity of nausea, and FLIE score were compared between the two groups. Results: Compared with the control group, the incidence of nausea decreased significantly in the observation group throughout the course of treatment (66.7% vs. 40.5%, p=0.016). At 24-120h after chemotherapy, the complete response rate of vomiting at the delayed stage increased conspicuously in the observation group (88.1% vs. 69.1%, p=0.033). At this stage, the proportion of patients without nausea in the observation group was also significantly higher (73.8% vs. 47.6%, p=0.014). The total FLIE scores in the observation group were conspicuously higher than the control group (106.05±15.35 vs. 95.04±20.02, p=0.02). Conclusion: The combination of the triple antiemetic regimen and low-frequency electrical acupoint stimulation memorably improves chemotherapy-induced nausea and vomiting in NSCLC patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of low-frequency electrical acupoint stimulation on nausea and vomiting in NSCLC patients receiving highly emetogenic regimens

Zhang

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Traditional Chinese medicine has abundant experience in the treatment of cancers and has definite curative effect on a variety of common tumors in the clinic. In addition, traditional Chinese medicine also exhibit a certain alleviation effect on the side effects caused by surgery, chemotherapy, and other treatments and some precancerous lesions [ 43 , 44 ]. A large number of studies have also proved that traditional Chinese medicine including Chinese herbal medicine, acupuncture, and moxibustion as well as other treatments exert their antitumor effects from multiple perspectives and multiple targets [ 44 – 52 ].…”

Section: Discussionmentioning

confidence: 99%

Real-World Evidence of Traditional Chinese Medicine (TCM) Treatment on Cancer: A Literature-Based Review

Peng

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

While randomized controlled trials (RCTs) are the gold standard for evidence-based medicine, they do not always reflect the real condition of patients in the real-world setting, which limits their generalizability and external validity. Real-world evidence (RWE), generated during routine clinical practice, is increasingly important in determining external effectiveness of the tightly controlled conditions of RCTs and is well recognized as a valuable complement to RCTs by regulatory bodies currently. Since it could provide new ideas and methods for clinical efficacy and safety evaluation of traditional Chinese medicine (TCM) and high-quality evidence support, real-world study (RWS) has received great attention in the field of medicine, especially in the field of TCM. RWS has shown desirable adaptability in the clinical diagnosis and treatment practice of traditional Chinese medicine. Consequently, it is increasingly essential for physicians and researchers to understand how RWE can be used alongside clinical trial data on TCM. Here, we discuss what real-world study is and outline the benefits and limitations of real-world study. Furthermore, using examples from TCM treatment on cancer, including Chinese herbal medicine, acupuncture, moxibustion, integrated TCM and Western medicine treatment, and other treatments, we elaborate how RWE can be used to help inform treatment decisions when doctoring patients with cancer in the clinic.

show abstract

Antiemetic effects of sclareol, possibly through 5-HT3 and D2 receptor interaction pathways: In-vivo and in-silico studies

Bappi,

Prottay,

Al-Khafaji

et al. 2023

Food and Chemical Toxicology

View full text Add to dashboard Cite

Research Progress on the Antiemetic Effect of Traditional Chinese Medicine Against Chemotherapy-Induced Nausea and Vomiting: A Review

Cited by 7 publications

References 98 publications

Effect of low-frequency electrical acupoint stimulation on nausea and vomiting in NSCLC patients receiving highly emetogenic regimens

Effect of low-frequency electrical acupoint stimulation on nausea and vomiting in NSCLC patients receiving highly emetogenic regimens

Real-World Evidence of Traditional Chinese Medicine (TCM) Treatment on Cancer: A Literature-Based Review

Antiemetic effects of sclareol, possibly through 5-HT3 and D2 receptor interaction pathways: In-vivo and in-silico studies

Contact Info

Product

Resources

About