Research progress on KIF3B and related diseases

Abstract

Kinesins constitute a protein superfamily that belongs to the motor protein group. Kinesins move along microtubules to exert their various functions, which include intracellular transportation, mitosis, and cell formation. Kinesins are responsible for the transport of various membrane organelles, protein complexes, mRNA and other material, as well as the regulation of intracellular molecular signal pathways.Cumulative studies have also indicated that kinesins are related to the development of a variety of human diseases. At present, there are 14 subfamilies of the kinesin superfamily (KIFs), comprising 45 members. KIF3 is the most common expression in KIFs. KIF3 is a complex composed of a KIF3A/3B heterodimer and a kinesin-related protein, known as KAP3. These complexes are organelles and protein complexes involved in membrane binding in various tissues and transport within cells (nerve cells, melanocytes, epithelial cells, etc.). As a member of the KIF3 subfamily, KIF3B is an essential protein that can regulate cell migration, and proliferation and has critical biological functions. During mitosis, KIF3B is responsible for vesicle transport and membrane expansion, thus regulating cell migration. In recent years, more and more attention has been paid to the relationship between KIF3B and the occurrence and development of diseases. This article reviews the recent advances in the study of KIF3B and its related diseases.

Immunological role and prognostic value of the SKA family in pan-cancer analysis

“…SKA1, along with SKA2 and SKA3, constitutes the spindle-and kinetochore-associated subunit complex. The SKA family is an indispensable element that stabilizes spindle microtubules attaching to the kinetochore (KT) and ensures the completion of the mitosis process (1)(2)(3)(4). Notably, dysregulated expression of SKA1/2/3 was involved in the tumorigenesis and progression of multiple cancer types such as liver cancer, breast cancer, cervical cancer and other malignant tumors (5)(6)(7), which in turn can affect the prognosis of cancer patients.…”

SKA1/2/3 serves as a biomarker for poor prognosis in human lung adenocarcinoma

“…Spindle and kinetochore associated complex subunit (SKA) was composed of three members, namely SKA1/2/3, which stabilized spindle microtubules attaching to kinetochore (KT) in the middle stage of mitosis, thus ensuring the accomplishment of mitosis process (6)(7)(8)(9). Studies had found that SKA1/2/3 were dysregulated and closely related to prognosis in liver cancer, breast cancer, cervical cancer and other malignant tumors (10)(11)(12).…”

YY1 modulates the radiosensitivity of esophageal squamous cell carcinoma through KIF3B-mediated Hippo signaling pathway

“…KIF3B is a molecular motor protein and consists of three domains: motor domains, PH, and FHA domains [ 29 ]. Conserved motor domains are responsible for connecting microtubules and ATP through the specified binding site, PH domains participate in transporting cargos and little is known about the FHA domains [ 30 ]. Recently, increasing attention has been paid to the relativity between KIF3B and the occurrence of tumors [ 31 ].…”

“…We selected the candidate protein ITGB1 which can interact with KIF3B. ITGB1 is an integrin and plays an important role in tumor progression and in the constitution of the cytoskeleton [ 33 ], where KIF3B is involved in intracellular transportation, mitosis, and cell formation which is dependent on cytoskeleton structures [ 30 ], Our IP and IF assays confirmed that KIF3B interacts with ITGB1. Moreover, previous studies reported that ITGB1 could influence DNA damage repair and radiosensitivity of breast and non-small lung cancer cells via regulating Hippo-YAP1 signaling pathway [ 23 , 34 ].…”