Research progress on cuproptosis in cancer

Feng, Qingbo; Huo, Chenyu; Wang, Maijian; Huang, Handong; Zheng, Xingbin; Xie, Ming

doi:10.3389/fphar.2024.1290592

Cited by 5 publications

(1 citation statement)

References 88 publications

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“…The use of copper complexes as anticancer agents has been reviewed early [6] in an article structured according to the type of ligands used to complex copper [7]. The interest in copper was boosted in the last few years, on the one hand, by the hypothesis that an endogenous metal might exhibit fewer adverse effects on the body than exogenous metals, such as platinum, and on the other hand, by the discovery of cuproptosis, a recently evidenced form of cell death mediated by copper, which has potential applications in the treatment of cancer [8][9][10][11], with the aim of overcoming anticancer drug resistances [12]. However, copper is also known to induce the proliferation of cancer cells, as it stimulates the proliferation and migration of endothelial cells, as well as numerous pro-angiogenic reactions [13], which are the first stages of tumor angiogenesis [14].…”

Section: Introductionmentioning

confidence: 99%

Dendritic Pyridine–Imine Copper Complexes as Metallo-Drugs

Laurent,

Maraval,

Bernardes-Génisson

et al. 2024

Molecules

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Since the discovery of cisplatin in the 1960s, the search for metallo-drugs that are more efficient than platinum complexes with negligible side effects has attracted much interest. Among the other metals that have been examined for potential applications as anticancer agents is copper. The interest in copper was recently boosted by the discovery of cuproptosis, a recently evidenced form of cell death mediated by copper. However, copper is also known to induce the proliferation of cancer cells. In view of these contradictory results, there is a need to find the most suitable copper chelators, among which Schiff-based derivatives offer a wide range of possibilities. Gathering several metal complexes in a single, larger entity may provide enhanced properties. Among the nanometric objects suitable for such purpose are dendrimers, precisely engineered hyperbranched macromolecules, which are outstanding candidates for improving therapy and diagnosis. In this review article, we present an overview of the use of a particular Schiff base, namely pyridine–imine, linked to the surface of dendrimers, suitable for complexing copper, and the use of such dendrimer complexes in biology, in particular against cancers.

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