Research Progress on Construction of Lutein-Loaded Nano Delivery System and Their Improvements on the Bioactivity

Abstract

Lutein belongs to the diverse group of pigments known as oxygenated carotenoids, also known as phytochrome and macular pigment, demonstrating excellent biological activity. However, its application is limited due to the difficulty of dissolution, poor stability, and low bioavailability. To solve these problems, delivery systems are considered to be one of the most promising choices. These delivery systems can improve the physical, chemical, and biological properties of lutein to a certain extent. Moreover, the system can also be adapted to the needs of production in our daily life. In this paper, the construction of lutein-loaded nano delivery systems and their influences on the bioactivity of lutein were reviewed based on previous researchers. The main materials were classified, and assistant substances, basic parameters, and properties were collected. The mechanisms were analyzed in terms of enhancing cellular uptake, improving bioavailability, and achieving targeted delivery. These results show that different materials have their own characteristics. This review aims to provide references for the production and application of lutein in the food industry.

Overview of processed excipients in ocular drug delivery: Opportunities so far and bottlenecks

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Protein-Mediated Carotenoid Delivery Suppresses the Photoinducible Oxidation of Lipofuscin in Retinal Pigment Epithelial Cells

“…However, the choice of bio-organic solvents capable of dissolving carotenoids in this method is strictly limited since the retinal pigment epithelium is a very sensitive kind of tissue, especially in the case of pathology. The delivery of carotenoids using nanoemulsion liposomes is being actively discussed nowadays and is considered to have several advantages [37][38][39]. However, in the liposomal form, the incorporation preferences and release of carotenoids, as well as their storage stability and lipid peroxidation capacity, are limited and greatly depend on the carotenoid type [40,41].…”