Research Progress on Circular RNA in Glioma

Abstract

The discovery of circular RNA (circRNA) greatly complements the traditional gene expression theory. CircRNA is a class of non-coding RNA with a stable cyclic structure. They are highly expressed, spatiotemporal-specific and conservative across species. Importantly, circRNA participates in the occurrence of many kinds of tumors and regulates the tumor development. Glioma is featured by limited therapy and grim prognosis. Cancer-associated circRNA compromises original function or creates new effects in glioma, thus contributing to oncogenesis. Therefore, this article reviews the biogenesis, metabolism, functions and properties of circRNA as a novel potential biomarker for gliomas. We elaborate the expression characteristics, interaction between circRNA and other molecules, aiming to identify new targets for early diagnosis and treatment of gliomas.

lncRNA MEG3 Inhibits the Proliferation and Growth of Glioma Cells by Downregulating Bcl-xL in the PI3K/Akt/NF-κB Signal Pathway

“…Recently, new data show that there are the cross-regulations between lncRNAs and small noncoding RNAs that affect the phenotypic diversity of glioblastoma subclasses [43]. In addition, circular RNAs (circRNAs) are also involved in the regulation of gene expression (acting as microRNA (miRNA) or RNA binding protein (RBP) sponges) ( [44,45]; M. [46]), and some circRNAs, such as circSMARCA5 and circHIPK3, are found to be good diagnostic biomarkers for glioblastoma multiforme [47], suggesting that circRNAs may also interact with MEG3 to play a role in glioblastoma progression. Our data from Transwell and proliferation experiments showed that overexpression of MEG3 inhibits the proliferation, migration, and invasion of glioma cells.…”