lncRNA MEG3 Inhibits the Proliferation and Growth of Glioma Cells by Downregulating Bcl-xL in the PI3K/Akt/NF-κB Signal Pathway

Abstract

This study was conducted to investigate the impact and mechanisms of lncRNA MEG3 on glioma cells. lncRNA MEG3 was lowly expressed in glioma cells as compared to noncancer cells. Overexpression of MEG3 significantly downregulated the expression of Bcl-xL, slightly upregulated the expression of NF-κB p65 and IκBα, and reduced the proliferation of glioma cells with increased apoptosis and the migration and invasion ability. Subsequently, glioma cells overexpressing MEG3 had less tumorgenicity in xenograft mouse models. It is likely that MEG3 induces apoptosis in glioma cells via downregulating the Bcl-xL gene in the PI3K/Akt/NF-κB signal pathway to reduce the development of glioma.

Comprehensive review of Bcl‐2 family proteins in cancer apoptosis: Therapeutic strategies and promising updates of natural bioactive compounds and small molecules

“…The AKT signaling pathway is frequently overactivated in cancer and contributes to apoptosis dysregulation and resistance to chemotherapy (Choudhary et al, 2015). AKT overexpression disrupts the natural balance of Bcl‐2 family proteins and promotes the upregulation of prosurvival Bcl‐2 proteins, such as Bcl‐xL and Bcl‐2, thereby inhibiting apoptosis (Jia & Yan, 2022; Pilling & Hwang, 2019). PUMA expression is induced by AKT inactivation through a mechanism that is dependent on GSK3β (Ambacher et al, 2012).…”