Research progress on acupuncture treatment in central nervous system diseases based on NLRP3 inflammasome in animal models

Zhang, Haiming; Luo, Dan; Chen, Rui; Wang, Shuhan; Zhao, Y. B.; Li, Jinxiao; Zhou, Meiling; Yu, Zhaomin; Zhang, Junli; Liang, Feng-Xia

doi:10.3389/fnins.2023.1118508

Cited by 3 publications

(1 citation statement)

References 73 publications

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“…NLRP3 (NOD-like receptor pyrin domain 3) is a multiprotein signaling transduction complex that is considered to be one of the main inflammasomes and is involved in various immune and inflammatory-related diseases of the central nervous system. It plays a crucial role in recognizing cellular damage and regulating the inflammatory response in stroke [ 15 ]. The TLR4/NF-κB/NLRP3 signaling pathway can further activate the transcription and expression of NLRP3 after participating in the inflammatory response [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia

Bian,

Liu,

et al. 2024

NeuroReport

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This study aims to investigate how electroacupuncture regulates the learning and memory abilities of poststroke cognitive impairment (PSCI) rats through the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Thirty male rats were randomly divided into three groups: sham surgery group, PSCI model group, and electroacupuncture group, with 10 rats in each group. Middle cerebral artery occlusion was used to establish the PSCI model. The Zea Longa method was used to score the rats’ neurological function. Electroacupuncture was utilized for 21 days to improve PSCI. The learning and memory abilities of rats were tested using the Morris water maze. Hematoxylin–eosin staining and immunofluorescence were used to find the hippocampus’ pathological changes. The concentration of interleukin-1β, interleukin-6, tumor necrosis factor-α, and interleukin-18 were detected by ELISA. The mRNA expression levels of associated inflammatory corpuscles were measured by quantitative real-time PCR. The protein expression levels of TLR4, MyD88, NF-κB, and NLRP3 were measured using western blotting. Electroacupuncture improved not only the learning and memory abilities of PSCI rats but also hippocampal morphology. Electroacupuncture inhibited the activation of microglia and the TLR4/NF-κB/NLRP3 signaling pathway. Electroacupuncture also reduced proinflammatory factors and restrained the mRNA levels of NLRP3-associated inflammatory cytokines. Its mechanism was related to inhibiting the expression of the TLR4/NF-κB/NLRP3 signaling pathway, attenuating the release of inflammatory factors, and regulating the activation of hippocampal microglia in the brain.

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Section: Introductionmentioning

confidence: 99%

Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia

Bian,

Liu,

et al. 2024

NeuroReport

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Plants, phytochemicals, and natural practices in complementary and alternative system of medicine for treatment of central nervous system disorders

Awuchi

2023

International Journal of Food Properties

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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

Han,

Li,

Chen

et al. 2023

Neural Regeneration Research

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Previous studies have demonstrated a bidirectional relationship between inflammation and depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat, and NLR family pyrin domain-containing 3 (NLRP3) inflammasomes is closely related to the pathogenesis of various neurological diseases. In patients with major depressive disorder, NLRP3 inflammasome levels are significantly elevated. Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies. In this review, we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome. Moreover, we outlined various therapeutic strategies that target the NLRP3 inflammasome, including NLRP3 inflammatory pathway inhibitors, natural compounds, and other therapeutic compounds that have been shown to be effective in treating depression. Additionally, we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression. Currently, there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment. The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression. Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.

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Research progress on acupuncture treatment in central nervous system diseases based on NLRP3 inflammasome in animal models

Cited by 3 publications

References 73 publications

Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia

Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia

Plants, phytochemicals, and natural practices in complementary and alternative system of medicine for treatment of central nervous system disorders

Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

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