Plants, phytochemicals, and natural practices in complementary and alternative system of medicine for treatment of central nervous system disorders

Awuchi, Chinaza Godswill

doi:10.1080/10942912.2023.2205039

Cited by 3 publications

(2 citation statements)

References 167 publications

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“…En el siglo XXI han aparecido varios enfoques terapéuticos basados en el empleo de plantas medicinales con la intención de buscar nuevas alternativas para un amplio abanico de enfermedades incluyendo las del Sistema Nervioso Central (SNC) (5). En este contexto, plantas con reconocida actividad sobre el SNC han sido consideradas como potenciales tratamientos o como fuente de fitoquímicos para este tipo de enfermedades.…”

Section: Introductionunclassified

THC y CBD una alternativa para el tratamiento del estrés en adultos: beneficios y controversias. Una revisión actualizada de la literatura

Silva Larrea,

Montenegro Arévalo

2024

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Introducción. El estrés es un trastorno producido por situaciones físicas o emocionales que afectan la homeostasis del cuerpo ocasionando cambios significativos en la salud. En el siglo XXI se han desarrollado terapias basadas en plantas medicinales, incluyendo aquellas que pueden tratar enfermedades del Sistema Nervioso Central. El uso de fitocannabinoides como THC y CBD han demostrado ser efectivos para reducir el estrés, pero han generado controversia debido a su uso recreativo y regulaciones. Objetivo. El propósito de este artículo es revisar la evidencia científica actual sobre los efectos beneficiosos y adversos del uso de THC y CBD en el tratamiento del estrés en adultos. Metodología. Se realizó una búsqueda y revisión bibliográfica empleando 3 palabras clave: estrés tratado con THC y CBD, stress and cannabis, treatment and stress and cannabis o marihuana empleando base de datos de alto impacto como PubMed, ScieLO, Scopus, Web of Science, Springer, Medline, Taylor & Francis, Redalyc, a través de las bases digitales de la Universidad Católica de Cuenca. Resultados. Varios de estos estudios que se citan en esta investigación, nos indican que estos metabolitos producen mejoras significativas en la mayoría de los pacientes. Los síntomas alcanzaron mejoras bajo el efecto de una dosificación flexible siguiendo un régimen estricto de cannabidiol y tetrahidrocannabinol. Conclusión. Los datos recopilados en este estudio han mostrado beneficios terapéuticos, por lo cual es crucial una investigación continua en este campo para comprender mejor los riesgos y beneficios de estos compuestos en el contexto del manejo del estrés en adultos. Área de estudio general: medicina. Área de estudio específica: uso terapéutico del cannabis medicinal. Tipo de estudio: Revisión bibliográfica.

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Section: Introductionunclassified

THC y CBD una alternativa para el tratamiento del estrés en adultos: beneficios y controversias. Una revisión actualizada de la literatura

Silva Larrea,

Montenegro Arévalo

2024

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“…Certain eating habits, nutrients and foodstuffs can promote significant impacts against de-pression through various molecular mechanisms [42,43]. Natural products and specific nutrients such as vegetables, fruits, medicinal plants, tea, and curcumin were found to reduce oxidative stress and inflammation, enhance the nervous system's performance, and alter biomarkers and signaling pathways related to anxiety and depressive symptoms [44][45][46][47]. These molecular mechanisms can improve monoamine neurotransmitter production and decrease the hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis [48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Association of Pregnant Women’s Perinatal Depression with Sociodemographic, Anthropometric and Lifestyle Factors and Perinatal and Postnatal Outcomes: A Cross-Sectional Study

Jacovides,

Papadopoulou,

Pavlidou

et al. 2024

JCM

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Background: In recent decades, the incidence of depression has gradually increased in the general population globally. Depression is also common during gestation and could result in detrimental gestational complications for both the mother and the fetus. The survey presented aimed to evaluate whether pregnant women’s perinatal depression could be associated with socio-demographic, anthropometry and lifestyle factors, and perinatal and postnatal outcomes. Methods: This is a cross-sectional survey conducted on 5314 pregnant women. Socio-demographic and lifestyle factors were recorded by relevant questionnaires via face-to-face interviews. Anthropometric parameters were measured by qualified personnel. Perinatal depressive symptomatology status was evaluated by Beck’s Depression Inventory (BDI-II) questionnaire. Results: Depressive symptoms throughout gestation were found in 35.1% of the enrolled women. Perinatal depression was significantly associated with lower educational and economic level, pre-pregnancy regular smoking and reduced levels of Mediterranean diet adherence levels, a higher prevalence of gestational diabetes and preterm birth, as well as a higher incidence of delivering by caesarean section and abnormal childbirth weight. Perinatal depression was also significantly associated with a higher prevalence of maternal postpartum depression and lower prevalence of exclusive breastfeeding practices, as well as with a higher incidence of childhood asthma. Conclusions: Pregnant women’s perinatal depression appears to be associated with various socio-demographic, anthropometry, and lifestyle characteristics and with a higher frequency of several adverse pregnancy complications. The present findings emphasize the importance of pregnant women’s perinatal mental health, highlighting the need to develop and apply public strategies and policies for psychological counseling and support of future mothers to minimize probable risk factors that may trigger perinatal depression. Novel well-organized, follow-up surveys of enhanced validity are highly recommended to establish more definitive conclusions.

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Computational Insight of Oleracone L, Portulacatone B, and Portulacatal from Portulaca oleracea L. as Potential Anticholinesterase Inhibitors for Alzheimer’s

Alshammari

2024

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Alzheimer’s disease, characterized by a decline in cognitive functions, is frequently associated with decreased levels of acetylcholine due to the overactivity of acetylcholinesterase (AChE). Inhibiting AChE has been a key therapeutic strategy in treating Alzheimer’s disease, yet the search for effective inhibitors, particularly from natural sources, continues due to their potential for fewer side effects. In this context, three new alkaloids—oleracone L, portulacatone B, and portulacatal—extracted from Portulaca oleracea L., have recently shown promising anticholinesterase activity in vitro. However, no experimental or computational studies have yet explored their binding potential. This study represents the first comprehensive in silico analysis of these compounds, employing ADME prediction, molecular docking, molecular dynamics simulations, and MM-PBSA calculations to assess their therapeutic potential. The drug-likeness was evaluated based on Lipinski, Pfizer, Golden Triangle, and GSK rules, with all three alkaloids meeting these criteria. The ADME profiles suggested that these alkaloids can effectively cross the blood–brain barrier, a critical requirement for Alzheimer’s treatment. Molecular docking studies revealed that oleracone L had the highest binding affinity (−10.75 kcal/mol) towards AChE, followed by portulacatal and portulacatone B, demonstrating significant interactions with crucial enzyme residues. Molecular dynamics simulations over 200 ns confirmed the stability of these interactions, with RMSD values below 2 Å for all complexes, indicating stable binding throughout the simulation period. RMSF and the radius of gyration analyses further corroborated the minimal impact of these alkaloids on the enzyme’s overall flexibility and compactness. Moreover, MM-PBSA calculations provided additional support for the binding efficacy, showing that oleracone L, with the most favorable binding energy, could be a superior inhibitor, potentially due to its stronger and more consistent hydrogen bonding and favorable electrostatic interactions compared to the other studied alkaloids. These computational findings highlight the binding efficiency and potential therapeutic viability of these alkaloids as AChE inhibitors, suggesting they could be promising candidates for Alzheimer’s disease treatment. The study underscores the importance of further validation through in vitro and in vivo experiments to confirm these predictions.

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Plants, phytochemicals, and natural practices in complementary and alternative system of medicine for treatment of central nervous system disorders

Cited by 3 publications

References 167 publications

THC y CBD una alternativa para el tratamiento del estrés en adultos: beneficios y controversias. Una revisión actualizada de la literatura

THC y CBD una alternativa para el tratamiento del estrés en adultos: beneficios y controversias. Una revisión actualizada de la literatura

Association of Pregnant Women’s Perinatal Depression with Sociodemographic, Anthropometric and Lifestyle Factors and Perinatal and Postnatal Outcomes: A Cross-Sectional Study

Computational Insight of Oleracone L, Portulacatone B, and Portulacatal from Portulaca oleracea L. as Potential Anticholinesterase Inhibitors for Alzheimer’s

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