Research Progress of Robot Technology in In situ 3D Bioprinting

Neng, Xie; Shi, Guohong; Shen, Yanjun; Xu, Yongfu; Wang, Hao; Haiyang, Feng; Dai, Kerong; Wang, Jinwu; Cao, Qixin

doi:10.18063/ijb.v8i4.614

Cited by 10 publications

(6 citation statements)

References 47 publications

(43 reference statements)

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“…The most common technique is ex vivo, where the scaffold is combined with cells and other biomolecules outside of the body [ 76 ]. The newer approach, in situ, aims to print tissue or organs directly in the human body at the required site of trauma [ 97 ]. This technology has a wide variety of potential applications.…”

Section: 3d Cell Culturesmentioning

confidence: 99%

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Górnicki,

Lambrinow,

Golkar-Narenji

et al. 2024

Nanomaterials

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Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible and can influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic scaffolds adds complexity to traditional cell cultivation methods. The most commonly used technique involves cultivating cells on a flat surface in a two-dimensional format due to its simplicity. A three-dimensional (3D) format can provide a microenvironment for surrounding cells. There are two main techniques for obtaining 3D structures based on the presence of scaffolding. Scaffold-free techniques consist of spheroid technologies. Meanwhile, scaffold techniques contain organoids and all constructs that use various types of scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels that are one of the most extensively studied forms of potential scaffolds for 3D culture up to 4D bioprinted biomaterials. 3D bioprinting is one of the most important techniques used to create biomimetic scaffolds. The versatility of this technique allows the use of many different types of inks, mainly hydrogels, as well as cells and inorganic substances. Increasing amounts of data provide evidence of vast potential of biomimetic scaffolds usage in tissue engineering and personalized medicine, with the main area of potential application being the regeneration of skin and musculoskeletal systems. Recent papers also indicate increasing amounts of in vivo tests of products based on biomimetic scaffolds, which further strengthen the importance of this branch of tissue engineering and emphasize the need for extensive research to provide safe for humansbiomimetic tissues and organs. In this review article, we provide a review of the recent advancements in the field of biomimetic scaffolds preceded by an overview of cell culture technologies that led to the development of biomimetic scaffold techniques as the most complex type of cell culture.

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Section: 3d Cell Culturesmentioning

confidence: 99%

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Górnicki,

Lambrinow,

Golkar-Narenji

et al. 2024

Nanomaterials

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“…While 3D bioprinting technology holds promise in alleviating the scarcity of organs for transplantation, challenges persist in the preoperative fabrication, in vitro cultivation, and transplantation processes, posing considerable risks and limitations [ 51 , 52 ]. The emerging in situ 3D bioprinting technology, which allows direct organ printing at the transplant site, shows the potential to mitigate these issues to some extent.…”

Section: Cell Requirements In Different 3d Bioprinting Techniquesmentioning

confidence: 99%

Advancements of 3D bioprinting in regenerative medicine: Exploring cell sources for organ fabrication

Ma,

Deng,

et al. 2024

Heliyon

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“…Handheld printing devices are convenient and permit the physician to directly print onto the wound site. However, their application is limited to simple structures and there is the risk of human error, especially if the device is heavy or uncomfortable to operate (MacAdam et al, 2022;Xie et al, 2022). Conversely, robotic technology can perform accurate, repetitive movements without human fatigue.…”

Section: In Situ 3d Bioprinting Skin Constructsmentioning

confidence: 99%

Moving lab-grown tissues into the clinic: organ-on-a-chip and bioengineered skin systems

Reed-McBain,

Patel,

Reed-McBain

et al. 2024

Front. Lab. Chip. Technol.

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For patients with end stage organ failure, organ transplant is frequently the only curative option available. However, organs available for transplant are in critically short supply around the world, which has led to lengthy wait times and increased mortality. Increased global life expectancy, coupled with raised age thresholds for recipients, has heightened demand and further compounded the need for alternative strategies. Bioengineering substitutes including organ-on-a-chip and 3D bioprinting technologies have made considerable strides toward whole organ generation. Skin is the organ where the most advances have been made thus far, due to the relatively less complex spatial architecture and industry interest in the development of sophisticated models for pharmaceutical and cosmetics testing. Here, we discuss the challenges of recapitulating the complexity of native skin, including a stratified structure, vascularization, and inclusion of skin appendages, such as hair follicles and sweat glands. We discuss current technological and biological progress in the field of tissue and organ bioengineering as well as highlight future challenges to generate de novo tissue for skin grafting.

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Research Progress of Robot Technology in In situ 3D Bioprinting

Cited by 10 publications

References 47 publications

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Advancements of 3D bioprinting in regenerative medicine: Exploring cell sources for organ fabrication

Moving lab-grown tissues into the clinic: organ-on-a-chip and bioengineered skin systems

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