Research progress of epigallocatechin-3-gallate (EGCG) on anti-pathogenic microbes and immune regulation activities

Zhao, Zijuan; Feng, Mengyu; Wan, Juan; Zheng, Xin; Teng, Cuiqin; Xie, Xinya; Pan, Wenjing; Hu, Baozhu; Huang, Jianan; Liu, Zhonghua; Wu, Jianhua; Cai, Shumin

doi:10.1039/d1fo01352a

Cited by 27 publications

(16 citation statements)

References 119 publications

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“…EGCG is one of the richest ingredients in green tea-derived polyphenols, and its biological activities have been extensively studied ( Jigisha et al, 2012 ; Steinmann et al, 2013 ). EGCG can inhibit infections by reducing biofilm formation and toxin release in bacteria ( Zhao et al, 2021 ). However, few studies have evaluated the clinical effect of EGCG in animal models.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-Gallate Ameliorates Acute Lung Damage by Inhibiting Quorum-Sensing-Related Virulence Factors of Pseudomonas aeruginosa

Tang

Hao

Khan³

et al. 2022

Front. Microbiol.

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The superbug Pseudomonas aeruginosa is among the most formidable antibiotic-resistant pathogens. With declining options for antibiotic-resistant infections, new medicines are of utmost importance to combat with P. aeruginosa. In our previous study, we demonstrated that Epigallocatechin-3-gallate (EGCG) can inhibit the production of quorum sensing (QS)-regulated virulence factors in vitro. Accordingly, the protective effect and molecular mechanisms of EGCG against P. aeruginosa-induced pneumonia were studied in a mouse model. The results indicated that EGCG significantly lessened histopathological changes and increased the survival rates of mice infected with P. aeruginosa. EGCG effectively alleviated lung injury by reducing the expression of virulence factors and bacterial burden. In addition, EGCG downregulated the production of pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6, and IL-17, and increased the expression of anti-inflammatory cytokines IL-4 and IL-10. Thus, the experimental results supported for the first time that EGCG improved lung damage in P. aeruginosa infection by inhibiting the production of QS-related virulence factors in vivo.

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Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-Gallate Ameliorates Acute Lung Damage by Inhibiting Quorum-Sensing-Related Virulence Factors of Pseudomonas aeruginosa

Tang

Hao

Khan³

et al. 2022

Front. Microbiol.

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“…They were proven to be highly stable, similarly compacted, and subject to low conformational variability [ 110 ]. EGCG, found in different plant sources including Camellia sinensis , Vitis vinifera , and black garlic extract, was further investigated in several in vitro and in vivo studies to test its effectiveness against COVID-19 [ 131 , 132 , 133 , 134 ]. EGCG and its oxidized form were found to inhibit Mpro in vitro [ 133 , 134 ], to directly inhibit an early infection [ 132 ], and to reduce viral replication in mouse lung cells [ 132 ].…”

Section: Phytochemicals As a Reservoir To Search For Sars-cov-2 Mpro ...mentioning

confidence: 99%

The Main Protease of SARS-CoV-2 as a Target for Phytochemicals against Coronavirus

Issa

Сокорнова

Zhidkin

et al. 2022

Plants

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In late December 2019, the first cases of COVID-19 emerged as an outbreak in Wuhan, China that later spread vastly around the world, evolving into a pandemic and one of the worst global health crises in modern history. The causative agent was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although several vaccines were authorized for emergency use, constantly emerging new viral mutants and limited treatment options for COVID-19 drastically highlighted the need for developing an efficient treatment for this disease. One of the most important viral components to target for this purpose is the main protease of the coronavirus (Mpro). This enzyme is an excellent target for a potential drug, as it is essential for viral replication and has no closely related homologues in humans, making its inhibitors unlikely to be toxic. Our review describes a variety of approaches that could be applied in search of potential inhibitors among plant-derived compounds, including virtual in silico screening (a data-driven approach), which could be structure-based or fragment-guided, the classical approach of high-throughput screening, and antiviral activity cell-based assays. We will focus on several classes of compounds reported to be potential inhibitors of Mpro, including phenols and polyphenols, alkaloids, and terpenoids.

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“…Similarly, Epigallocatechin gallate (EGCG, tea polyphenol), which is present in green tea, also showed anti-biofilm and anti-infection activities by Stenotrophomonas maltophilia and P. aeruginosa by reduction of C4-AHL production ( Vidigal et al, 2014 ; Hao et al, 2021 ). In mice, these compounds protect mice from infections by different pathogens, including methicillin-resistant S. aureus ( Long et al, 2019 ), H. pylori ( Muhammad et al, 2015 ; Deng et al, 2022 ), and S. typhimurium ( Wang et al, 2021 ; Zhao et al, 2021 ).…”

Section: Quorum Sensingmentioning

confidence: 99%

Recent advances on the regulation of bacterial biofilm formation by herbal medicines

Zhang

Wang

et al. 2022

Front. Microbiol.

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Biofilm formation is a fundamental part of life cycles of bacteria which affects various aspects of bacterial-host interactions including the development of drug resistance and chronic infections. In clinical settings, biofilm-related infections are becoming increasingly difficult to treat due to tolerance to antibiotics. Bacterial biofilm formation is regulated by different external and internal factors, among which quorum sensing (QS) signals and nucleotide-based second messengers play important roles. In recent years, different kinds of anti-biofilm agents have been discovered, among which are the Chinese herbal medicines (CHMs). CHMs or traditional Chinese medicines have long been utilized to combat various diseases around the world and many of them have the ability to inhibit, impair or decrease bacterial biofilm formation either through regulation of bacterial QS system or nucleotide-based second messengers. In this review, we describe the research progresses of different chemical classes of CHMs on the regulation of bacterial biofilm formation. Though the molecular mechanisms on the regulation of bacterial biofilm formation by CHMs have not been fully understood and there are still a lot of work that need to be performed, these studies contribute to the development of effective biofilm inhibitors and will provide a novel treatment strategy to control biofilm-related infections.

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Research progress of epigallocatechin-3-gallate (EGCG) on anti-pathogenic microbes and immune regulation activities

Abstract: At the end of 2019, the COVID-19 virus spread worldwide, infecting millions of people. Infectious diseases induced by pathogenic microorganisms such as influenza virus, hepatitis virus, and Mycobacterium tuberculosis are...

Cited by 27 publications

References 119 publications

Epigallocatechin-3-Gallate Ameliorates Acute Lung Damage by Inhibiting Quorum-Sensing-Related Virulence Factors of Pseudomonas aeruginosa

Epigallocatechin-3-Gallate Ameliorates Acute Lung Damage by Inhibiting Quorum-Sensing-Related Virulence Factors of Pseudomonas aeruginosa

The Main Protease of SARS-CoV-2 as a Target for Phytochemicals against Coronavirus

Recent advances on the regulation of bacterial biofilm formation by herbal medicines

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