Research Progress in the Treatment of Complications and Sequelae of COVID-19

Abstract

With the improvement in the understanding of COVID-19 and the widespread vaccination of COVID-19 vaccines in various countries, the epidemic will be brought under control soon. However, multiple viruses could result in the post-viral syndrome, which is also common among patients with COVID-19. Therefore, the long-term consequences and the corresponding treatment of COVID-19 should be the focus in the post-epidemic era. In this review, we summarize the therapeutic strategies for the complications and sequelae of eight major systems caused by COVID-19, including respiratory system, cardiovascular system, neurological system, digestive system, urinary system, endocrine system, reproductive system and skeletal complication. In addition, we also sorted out the side effects reported in the vaccine trials. The purpose of this article is to remind people of possible complications and sequelae of COVID-19 and provide robust guidance on the treatment. It is extremely important to conduct long-term observational prognosis research on a larger scale, so as to have a comprehensive understanding of the impact of the SARS-CoV-2 on the human body and reduce complications to the greatest extent.

Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature

“…Of the 64 patients, 50 (78.1%) received an mRNA vaccine (Pfizer/BioNTech BNT162b2 or Moderna mRNA-1273), 13 (20.3%) received a viral vector vaccine (Vaxzevria ChAdOx1 or Convidecia AD5-nCOV or Jennsen), and only one (1.6%) received an inactivated virus vaccine (Sinovac Biotech CoronaVac). Median time between the vaccine shot (any type) and the symptoms' development was 10 days (4)(5)(6)(7)(8)(9)(10)(11)(18)(19)(20)(21)(22)(23). Concerning the relationship between the dose of vaccine and Graves' disease onset, 35 patients (54.7%) became symptomatic after the first dose, in 27 (42.2%) after the second dose, and in one case after the third dose.…”

Keeping up with the COVID's—Could siRNA‐based antivirals be a part of the answer?

“…[ 19 ] The reason behind the lasting effects is largely unknown, but thought to be resultant of an effect observed in other viruses, known as ‘post viral syndrome’. [ 20 ] Although to date the most devastating features of COVID‐19 infection have manifested in the lungs, all organs are potentially affected by the virus. Table 2 adapted from a recent review from Wang et al., which focuses exclusively on research surrounding the long‐term effects of the COVID‐19 virus, outlines the various potential side effects on organs and tissues long after the virus has gone.…”

Screening the Potential Biomarkers of COVID-19-Related Thrombosis Through Bioinformatics Analysis

“…As of February 2022, nearly 400 million people have been diagnosed with COVID-19 worldwide, and more than 5.7 million people have died. COVID-19 can induce different complications and affect different organs ( Drake et al, 2021 ; Wang et al, 2021 ), mainly the respiratory tract, heart, gastrointestinal tract ( Serban et al, 2021 ; Bulte et al, 2022 ), central nervous system ( Sriwastava et al, 2021 ), liver, and kidney ( Gross et al, 2020 ). Elderly individuals and patients with underlying diseases are prone to severe cases, and their mortality rates are significantly higher than those of other populations ( Ghasemiyeh et al, 2021 ).…”