Research progress in laboratory detection of SARS-CoV-2

Objective: Despite efforts to encourage breastfeeding, exclusive breastfeeding (EBF) rates in the Bronx remain suboptimal. Hospital restrictions and uncertainty surrounding the side effects of COVID-19 greatly impacted the mother-infant dyad during the postpartum hospitalization. Preliminary studies found an initial decrease in EBF, but lasting effects remain unknown. This study aimed to investigate the effect of the COVID-19 pandemic on birth hospitalization EBF rates among a high-risk urban patient population. Study Design: A retrospective chart review was conducted on all newborns admitted to the newborn nursery at an urban medical center between 2019 and 2021. Patients were separated into pre-pandemic and pandemic cohorts. Patient demographics, maternal comorbidities, length of stay, feeding method, and newborn characteristics, including status as high risk for hypoglycemia, were collected. EBF was defined as receiving only mother’s milk during the birth hospitalization. Descriptive statistics and bivariate analysis were used to examine the data. Results: 630 pre-pandemic and 643 pandemic newborns were included. The cohorts did not differ in baseline maternal characteristics. Pre-pandemic newborns were less likely to be high risk (23.3% vs. 29.4%, p= 0.01), more likely to see the hospital lactation consultant (53.2% vs. 24.0%, p< 0.001), and had a longer average length of stay (63.4 vs. 54.5 hours, p< 0.001). Most infants in both cohorts received some breastmilk during the hospitalization (97.6% vs. 94.6%, NS). There was no difference in EBF between cohorts among all newborns (9.5% vs. 11.4%, p= 0.29), or among non-high-risk newborns (12.2% vs. 15.0%, p=0.22). Conclusion: EBF rates in the Bronx, NY did not change during the pandemic period, despite an increase in high-risk newborns. Further investigation into the effect of lactation consultation, maternal race, ethnicity, and primary language should be further explored to understand the implications of healthcare disparities on the mother-infant dyad.

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“…16 Another reported an 11% decrease in EBF in the newborn nursery during the postpartum hospitalization. 17…”

Section: Discussionmentioning

confidence: 99%

Exclusive Breastfeeding in the Bronx—Successes and Shortcomings

2023

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“…During the process or at the end point for detection, fluorescent signals are read. Wang et al. (2021) evaluated the quality of 6 approved commercial nucleic acid assay kits, and the results showed that the lower limits of these kits differed greatly ( Wang et al., 2020 ).…”

Section: Methods Of Natmentioning

confidence: 99%

Laboratory detection of SARS-CoV-2: A review of the current literature and future perspectives

Liu

Mao²,

Ni³

et al. 2022

Heliyon

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“…Therefore, the monitoring of new variants and the possible impacts of transmission, pathogenicity and immune evasion are the focus of current pandemic prevention and control. Real-time fluorescence quantitative PCR nucleic acid detection has high specificity and sensitivity and has become the “gold standard” for diagnosing SARS-CoV-2 infection ( Wang H. et al, 2022 ). However, because SARS-CoV-2 is an RNA virus, variation in the target sequence develops easily, and too low a viral content in the sample to be detected due to weakening of the virus shedding ability and even some inappropriate operations (including sample collection, transportation, storage and processing, etc.)…”

Section: Establish a Mode To Cope With The Covid-19 Epidemicmentioning

confidence: 99%

Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future

et al. 2023

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Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant pneumonia in December 2019, the cumulative number of infected people worldwide has exceeded 670 million, with over 6.8 million deaths. Despite the marketing of multiple series of vaccines and the implementation of strict prevention and control measures in many countries, the spread and prevalence of SARS-CoV-2 have not been completely and effectively controlled. The latest research shows that in addition to angiotensin converting enzyme II (ACE2), dozens of protein molecules, including AXL, can act as host receptors for SARS-CoV-2 infecting human cells, and virus mutation and immune evasion never seem to stop. To sum up, this review summarizes and organizes the latest relevant literature, comprehensively reviews the genome characteristics of SARS-CoV-2 as well as receptor-based pathogenesis (including ACE2 and other new receptors), mutation and immune evasion, vaccine development and other aspects, and proposes a series of prevention and treatment opinions. It is expected to provide a theoretical basis for an in-depth understanding of the pathogenic mechanism of SARS-CoV-2 along with a research basis and new ideas for the diagnosis and classification, of COVID-19-related disease and for drug and vaccine research and development.

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Research progress in laboratory detection of SARS-CoV-2

Cited by 6 publications

References 45 publications

Exclusive Breastfeeding in the Bronx—Successes and Shortcomings

Exclusive Breastfeeding in the Bronx—Successes and Shortcomings

Laboratory detection of SARS-CoV-2: A review of the current literature and future perspectives

Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future

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