Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

Chen, Huiming; Li, Hang; Lin, Meng-Xian; Fan, Wei; Zhang, Yi; Lin, Yi-Chun; Wu, Shu-Xiang

doi:10.3389/fgene.2022.952667

Cited by 6 publications

(4 citation statements)

References 161 publications

(126 reference statements)

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“…Anti-angiogenic therapy is an important modality for digestive system tumor treatment ( 122 ). Due to the low mutation rate of anti-angiogenic genes in CRC ( 122 ), epigenetic modifications may provide a more appropriate target for blocking tumor angiogenesis. The role of m6A regulation in tumor angiogenesis is currently a topic of intense research.…”

Section: Potential Research Direction For Mettl14 and Digestive Syste...mentioning

confidence: 99%

METTL14‑mediated RNA methylation in digestive system tumors

Lin

Wang

et al. 2023

Int J Mol Med

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N6-methyladenosine (m6A) RNA methylation is one of the most common post-transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase-like 14 (METTL14) is a particularly important m6A methylation 'writer' that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different biological processes. Malignancies in the digestive system are some of the most common malignancies found in humans, which are typically associated with poor prognoses with limited clinical solutions. METTL14-mediated methylation has been implicated in both the potentiation and inhibition of digestive system tumor growth, cell invasion and metastasis, in addition to drug resistance. In the present review, the research progress and regulatory mechanisms of METTL14-mediated methylation in digestive system malignancies were summarized. In addition, future research directions and the potential for its clinical application were examined.

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Section: Potential Research Direction For Mettl14 and Digestive Syste...mentioning

confidence: 99%

METTL14‑mediated RNA methylation in digestive system tumors

Lin

Wang

et al. 2023

Int J Mol Med

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“…In the present study, we first screened 29 m7G regulators differentially expressed in osteosarcoma and found them abundant in biological functions such as initiation and regulation of translation and RNA catabolic processes by enrichment analysis. In fact, m7G methylation, as a critical component of post-transcriptional modification, is involved in various aspects of cancer RNA metabolism that have been extensively characterized, including miRNA maturation, mRNA translation, and mRNA decay [22] , [67] , [68] . In hepatocellular carcinoma, METTL1-mediated m7G tRNA modification enhanced mRNA translation in a codon frequency-dependent manner and accelerated tumorigenesis and progression in vitro and in vivo [20] .…”

Section: Discussionmentioning

confidence: 99%

Comprehensive multi-omics analysis reveals m7G-related signature for evaluating prognosis and immunotherapy efficacy in osteosarcoma

Zhang¹,

Gan²,

Ru³

et al. 2023

Journal of Bone Oncology

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“…5-Methylcytosine (m 5 C) methylation was considered an mRNA modification approach first reported in 1925 [ 12 – 14 ]. As recognized by previous studies, this RNA modification is also regulated by writers, readers, and erasers and plays an important role in biological progression by influencing RNA stability, transcription efficiency, and localization [ 15 – 17 ]. Reportedly, m 5 C can affect tumor progression, prognosis, and TIME as well as resistance to immunotherapy and chemotherapy [ 15 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, this kind of lncRNA is also considered a promising biomarker and potential target for tumor diagnosis and may provide a novel strategy to guide individualized precise treatment for tumor patients. Increasing evidence-based studies have determined that m 5 C can regulate related lncRNAs to participate and influence biological processes [ 15 – 17 , 22 ]. Previous studies have shown that NSUN2 can alter gene and lncRNA expression as well as enhance protein synthesis and translation [ 14 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

5-Methylcytosine-related lncRNAs: predicting prognosis and identifying hot and cold tumor subtypes in head and neck squamous cell carcinoma

Huang

Zhou

et al. 2023

World J Surg Onc

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Background 5-Methylcytosine (m5C) methylation is recognized as an mRNA modification that participates in biological progression by regulating related lncRNAs. In this research, we explored the relationship between m5C-related lncRNAs (mrlncRNAs) and head and neck squamous cell carcinoma (HNSCC) to establish a predictive model. Methods RNA sequencing and related information were obtained from the TCGA database, and patients were divided into two sets to establish and verify the risk model while identifying prognostic mrlncRNAs. Areas under the ROC curves were assessed to evaluate the predictive effectiveness, and a predictive nomogram was constructed for further prediction. Subsequently, the tumor mutation burden (TMB), stemness, functional enrichment analysis, tumor microenvironment, and immunotherapeutic and chemotherapeutic responses were also assessed based on this novel risk model. Moreover, patients were regrouped into subtypes according to the expression of model mrlncRNAs. Results Assessed by the predictive risk model, patients were distinguished into the low-MLRS and high-MLRS groups, showing satisfactory predictive effects with AUCs of 0.673, 0.712, and 0.681 for the ROCs, respectively. Patients in the low-MLRS groups exhibited better survival status, lower mutated frequency, and lower stemness but were more sensitive to immunotherapeutic response, whereas the high-MLRS group appeared to have higher sensitivity to chemotherapy. Subsequently, patients were regrouped into two clusters: cluster 1 displayed immunosuppressive status, but cluster 2 behaved as a hot tumor with a better immunotherapeutic response. Conclusions Referring to the above results, we established a m5C-related lncRNA model to evaluate the prognosis, TME, TMB, and clinical treatments for HNSCC patients. This novel assessment system is able to precisely predict the patients’ prognosis and identify hot and cold tumor subtypes clearly for HNSCC patients, providing ideas for clinical treatment.

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Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

Cited by 6 publications

References 161 publications

METTL14‑mediated RNA methylation in digestive system tumors

METTL14‑mediated RNA methylation in digestive system tumors

Comprehensive multi-omics analysis reveals m7G-related signature for evaluating prognosis and immunotherapy efficacy in osteosarcoma

5-Methylcytosine-related lncRNAs: predicting prognosis and identifying hot and cold tumor subtypes in head and neck squamous cell carcinoma

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