Research Professionals’ Perspectives, Barriers, and Recommendations Regarding Minority Participation in Clinical Trials

Kurt, Anita; Semler, Lauren; Meyers, Matthew; Porter, Bernadette Glenn; Jacoby, Jeanne L; Stello, Brian

doi:10.1007/s40615-016-0322-0

Cited by 16 publications

(13 citation statements)

References 29 publications

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“…Until existing enrollment biases are eliminated, novel study designs, such as the present study, will be necessary to construct clinical databases more representative of US demographics. Counter to prevailing beliefs and a report suggesting that nonwhite race and patient-physician language discordance serve as impediments to clinical trial enrollment, 26 we demonstrate that, with appropriate site se-lection and concerted effort, women and minorities can be enrolled in a large, national, multicenter PCI outcomes study at a rate comparable with conventional studies. By completing enrollment 6 months ahead of schedule, the PD study enrolled patients faster than PE Plus.…”

Section: Discussionmentioning

confidence: 99%

Outcomes in Women and Minorities Compared With White Men 1 Year After Everolimus-Eluting Stent Implantation

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Outcomes in Women and Minorities Compared With White Men 1 Year After Everolimus-Eluting Stent Implantation

et al. 2017

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“…19 Another study in 2017 claims language and repeated follow-ups of the patient and record maintenance a barriers to research. 20 With current study findings and previous data available, it is concluded that a widespread adaptation of system-based reforms should be launched to help, educate, guide, counsel and facilitate research students. This will not only encourage them but also make it easily accessible for them.…”

Section: Discussionmentioning

confidence: 64%

Barriers Faced by Medical and Dental House-Officer During Research in Twin Cities of Pakistan

Arshad

Ahmed²,

Ibrahim³

et al. 2022

PAFMJ

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Objective: To determine the research activities and perceived barriers among house officers working in different institutions in Rawalpindi/ Islamabad. Study Design: Cross-sectional study. Place and Duration of Study: Private and Government Hospitals in Rawalpindi and Islamabad Pakistan, from May to Oct 2019. Methodology: A questionnaire based on thirteen questions with close-ended answers was administered to house officers at different dental hospitals in Rawalpindi and Islamabad to observe the attitudes toward research and perceived difficulties in doing research. Results: A total of 126 participants with the mean age of 24.26±2.192 years participated in the study. Out of 126, 68(58.3%) participants showed research interest, and 86(68.25%) participants reported no previous experience with research. In addition, barriers/difficulties in the research were noted regarding personal interests, funding, future job commitment and the data collection process. Conclusions: Within the limitations of this study, it is concluded that the barriers identified in this study need to be addressed in order to enhance students' participation in research and improve the quality of research done in our country: these barriers such as lack of interest, lack of funding, poor availability of research mentors and proper awareness should be removed. Amendments may be required in the dental undergraduate curriculum to overcome these barriers.

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“…BSSR approaches can help with the development of materials to support understanding of HIV cure research so that diverse groups can more easily participate in and contribute to HIV cure research. BSSR can help ensure that participants mirror the HIV epidemic when testing HIV cure interventions, so that results are more generalizable, and interventions are safe and effective in all populations .…”

Section: Discussionmentioning

confidence: 99%

Applying the Behavioural and Social Sciences Research (BSSR) Functional Framework to HIV Cure Research

et al. 2019

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Introduction The search for an HIV cure involves important behavioural and social processes that complement the domains of biomedicine. However, the field has yet to tap into the full potential of behavioural and social sciences research (BSSR). In this article, we apply Gaist and Stirratt’s BSSR Functional Framework to the field of HIV cure research. Discussion The BSSR Functional Framework describes four key research domains: (1) basic BSSR (understanding basic behavioural and social factors), (2) elemental BSSR (advancing behavioural and social interventions), (3) supportive BSSR (strengthening biomedically focused clinical trials), and (4) integrative BSSR (building multi‐disciplinary combination approaches for real‐world implementation). In revisiting and applying the BSSR Functional Framework, we clarify the importance of BSSR in HIV cure research by drawing attention to such things as: how language and communication affect the meaning of “cure” to people living with HIV (PLHIV) and broader communities; how cure affects the identity and social position of PLHIV; counselling and support interventions to address the psychosocial needs and concerns of study participants related to analytical treatment interruptions (ATIs); risk reduction in the course of ATI study participation; motivation, acceptability, and decision‐making processes of potential study participants related to different cure strategies; HIV care providers’ perceptions and attitudes about their patients’ participation in cure research; potential social harms or adverse social events associated with cure research participation; and the scalability of a proven cure strategy in the context of further advances in HIV prevention and treatment. We also discuss the BSSR Functional Framework in the context of ATIs, which involve processes at the confluence of the BSSR domains. Conclusions To move HIV cure regimens through the translational research pathway, attention will need to be paid to both biomedical and socio‐behavioural elements. BSSR can contribute an improved understanding of the human and social dimensions related to HIV cure research and the eventual application of HIV cure regimens. The BSSR Functional Framework provides a way to identify advances, gaps and opportunities to craft an integrated, multi‐disciplinary approach at all stages of cure research to ensure the real‐world applicability of any strategy that shows promise.

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Research Professionals’ Perspectives, Barriers, and Recommendations Regarding Minority Participation in Clinical Trials

Cited by 16 publications

References 29 publications

Outcomes in Women and Minorities Compared With White Men 1 Year After Everolimus-Eluting Stent Implantation

Outcomes in Women and Minorities Compared With White Men 1 Year After Everolimus-Eluting Stent Implantation

Barriers Faced by Medical and Dental House-Officer During Research in Twin Cities of Pakistan

Applying the Behavioural and Social Sciences Research (BSSR) Functional Framework to HIV Cure Research

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