Research on the Extraction and Purification of Dihydromyricetin from &lt;i&gt;Ampelopsis grossedentata&lt;/i&gt;

Guo, Jie; Tang, Hao Guo; Yao, Hong Juan; Zhang, Yan Mei

doi:10.4028/www.scientific.net/amr.1033-1034.738

Cited by 1 publication

(1 citation statement)

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“…The dihydromyricetin (DHM), also known as (+)-ampelopsin, is a flavonoid commonly found in the Ampelopsis genus used in the traditional Chinese medicine [2][3][4][5]. This flavanone presents versatile pharmacological and biological activities, including improved skeletal muscle insulin sensitivity, hepatoprotective activity, inhibits alcohol-induced muscular relaxation, counteracts alcohol intoxication and dependence, cough relief as well as anti-microbial, anti-hypertension, anti-oxidation, anti-carcinogenic and anti-inflammatory effects [6][7][8].…”

Section: Introduction mentioning

confidence: 99%

Determination of Dihydromyricetin in Cassia ferruginea (Schrad.) DC. by Quantitative 1H NMR (qHNMR)

Silva¹,

Correia²,

Marconcini³

et al. 2019

JPP

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Cassia ferruginea (Schrad.) DC. (Fabaceae) is a native plant widely used as an ornamental tree and for the restoration of degraded areas in Brazil. Although no previous ethnopharmacological or chemical information was available, bioprospecting studies on this species found out a high concentration of dihydromyricetin (DHM) in different parts of the plant. DHM, also known as (+)-ampelopsin, is a flavonoid that presents important pharmacological and biological activities, including anticancer, cardioprotective and hepatoprotective effects. The aim of this study was to develop and validate a simple method for the determination of DHM in hydroethanolic extracts of C. ferruginea by quantitative 1 H NMR (qHNMR) using the internal standard approach. The parameters as linearity, specificity and selectivity, accuracy, precision (repeatability and intermediate) and robustness showed satisfactory results. Five ethanolic extracts from different stages and organs of C. ferruginea were investigated, the DHM concentration ranges from 52.08 ± 3.95 to 201.83 ± 4.71 mg/g. The proposed method appears to be a suitable tool for fast quality control of herbal extracts, with no need of tedious sample preparation and chromatographic separations increasing the efficiency of natural products analysis. This is the first study reporting the presence and determination of DHM in Cassia ferruginea (Schrad.) DC.

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