Research on the Correlation of Trace Elements in Whole Blood With Acute Leukemia by Pixe

Abstract

The contents of multi-elements in whole blood from 115 patients with 7 different types of acute leukemia and 38 well matched healthy controls have been determined by means of proton induced X-ray emission (PIXE). The number of available analyzed elements was as many as 11, mainly due to the use of a 100 um thick Cr funny foi1 as an absorber. The contents of elements Cu, Ca, S, P, Si and the ratio of Cu to Zn (Cu/Zn) were higher and those of elements Zn, K, Fe, Al and Rb were lower with high significant differences (P<0. 01) in acute leukemia patients than in norma1 controls. The results indicate that the contents of Cu, Zn, and the ratio Cu/Zn are useful indices of disease activity. The elements of Al and Rb may play important roles in acute leukemia etiology,

Methodological studies of PIXE on biological and environmental science

“…A1, Si, P, S, K, Ca, Mn, Fe, Cu, Zn and Rb. A fairly good result of the correlation of trace elements in whole blood with acute leukemia was obtained [4,5]. The results showed that the 0168-583X/96/$15.00 Copyright © 1996 Elsevier Science B.V. All rights reserved SSDI 0168-583X(95 )00889-6 II.…”