Extraordinarily frequent and long-lasting snowstorms affected China in January 2008, causing abovenormal precipitation, below-normal temperature, and severe icing conditions over central-southern China. These snowstorms were closely linked to the change in the Middle East jet stream (MEJS), which intensified and shifted southeastward. The change in MEJS was accompanied by southeastward shifts of the ridge and the trough over Europe and western Asia. The intensified MEJS also strengthened the trough embedded in the southern branch of the subtropical westerlies over the southern Tibetan Plateau, enhancing the water vapor transport from western Asia and the Bay of Bengal to China. In the meantime, the subtropical western Pacific high (SWPH) was stronger and its ridgeline was farther north than normal. The anomalous high slowed down the eastward propagation of weather systems to the Pacific and favored convergence of water vapor over central-southern China. The MEJS is usually strong when the Arctic Oscillation (AO) is positive and the SWPH is farther north than normal in La Niñ a winters. Compared to the SWPH and the Niñ o-3.4 sea surface temperature (SST), the MEJS and the AO exert stronger influences on the temperature and the precipitation over central-southern China, despite the fact that these possible impacting factors are not completely independent from each other. Although the La Niñ a event might contribute to the climate anomalies through its relation with the SWPH in January 2008, an analysis of historical events indicates that La Niñ a conditions alone can hardly cause severe and persistent snow conditions over central-southern China. In addition, compared to the Niñ o-3.4 SST and the SWPH, the conditions of December MEJS and AO exhibit stronger precursory signals of the variability of January temperature over central-southern China.

Many studies have found that mercury (Hg) exposure is associated with selenium (Se) accumulation in vivo. However, human studies are limited. To study the interaction between Se and Hg, we investigated the total Se and Hg concentrations in body fluids and serum Se-containing proteins in individuals exposed to high concentrations of Hg. Our objective was to elucidate the possible roles of serum Se and selenoproteins in transporting and binding Hg in human populations. We collected data from 72 subjects: 35 had very low Hg exposure as evidenced by mean Hg concentrations of 0.91 and 1.25 ng/mL measured in serum and urine, respectively; 37 had high exposure (mean Hg concentrations of 38.5 and 86.8 ng/mL measured in serum and urine, respectively). An association between Se and Hg was found in urine (r = 0.625; p < 0.001) but not in serum. Hg exposure may affect Se concentrations and selenoprotein distribution in human serum. Expression of both selenoprotein P and glutathione peroxidase (GSH-Px) was greatly increased in Hg miners. These increases were accompanied by elevated Se concentrations in serum. In addition, selenoprotein P bound more Hg at higher Hg exposure concentrations. Biochemical observations revealed that both GSH-Px activity and malondialdehyde concentrations increased in serum of the Hg-exposed group. This study aids in the understanding of the interaction between Se and Hg. Selenoproteins play two important roles in protecting against Hg toxicity. First, they may bind more Hg through their highly reactive selenol group, and second, their antioxidative properties help eliminate the reactive oxygen species induced by Hg in vivo.

Editor’s note: For easy download the posted pdf of the State of the Climate for 2019 is a low-resolution file. A high-resolution copy of the report is available by clicking here. Please be patient as it may take a few minutes for the high-resolution file to download.

Editor’s note: For easy download the posted pdf of the State of the Climate for 2017 is a low-resolution file. A high-resolution copy of the report is available by clicking here. Please be patient as it may take a few minutes for the high-resolution file to download.

Background: Mercury is a ubiquitous and highly toxic environmental pollutant. In this study, we evaluated the relationship between mercury exposure and oxidative stress, serum and urinary mercury concentrations, oxidative DNA damage, and serum redox status in chronically mercury-exposed persons compared with healthy controls. Methods: We measured urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), which we used as a biomarker of oxidative DNA damage in the mercury-exposed persons, by HPLC with electrochemical detection (ECD). We evaluated antioxidant status by measuring the activities of superoxide dismutase and glutathione peroxidase and the concentrations of total reduced glutathione and protein-bound thiols in serum. Results: The significant increase in 8-OHdG concentrations in urine indicated that mercury-induced oxidative damage to DNA occurred in vivo. Differences in body mercury burden and antioxidant enzyme activities were statistically significant between the mercury-exposed

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Editors note: For easy download the posted pdf of the State of the Climate for 2014 is a very low-resolution file. A high-resolution copy of the report is available by clicking here. Please be patient as it may take a few minutes for the high-resolution file to download.