Research on Tachykinins: Clinical Trends

Pernow, Bengt

doi:10.1007/978-1-4612-4672-5_123

Cited by 125 publications

(170 citation statements)

References 16 publications

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“…Substance P (SP) and the structurally-related mammalian peptides neurokinin A (NKA), neurokinin B (NKB), neuropeptide K (NPK) and neuropeptide-y (NP-y), belong to the tachykinin family of neuropeptides and are believed to mediate a variety of physiological processes, both centrally and in the periphery (see Pernow, 1983;Maggio 1988). It is now widely accepted that these neuropeptides interact with at least three types of tachykinin receptor, termed NKI,NK2 and NK3 (see Guard & Watson, 1991).…”

Section: Introductionmentioning

confidence: 99%

The interaction of the NK₁ receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences

Guard

Boyle

Tang

et al. 1993

British J Pharmacology

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1 We investigated the effects of the non-peptide NK1 receptor antagonist, CP-96,345, its inactive enantiomer CP-96,344, and the racemic mixture ( ± )-CP-96,345, on the binding of [3H]-nimodipine and [3H]-diltiazem to L-type calcium channels in rat cerebral cortex membranes. In isolated peripheral tissues containing tachykinin receptors, the effects of (± )-CP-96,345 have been compared with those of diltiazem.2 In guinea-pig trachea, (± )-CP-96,345 produced antagonism of responses to the selective NK, agonists [Sar9, Met(02)"]SP and substance P-methyl ester that was apparently competitive in nature (pKB 7.0-7.5), while in guinea-pig ileum the antagonism was not surmountable. 3 The reduction of maximum responses by ( ± )-CP-96,345 in the guinea-pig ileum was not selective; it was obtained with muscarinic agonists and other agents, and was also observed in the portal vein of the rat where NK, receptors are not present. The functional effect that may be observed in integrated models will be a consequence of either property, or be a composite effect of NK, receptor antagonism and L-channel blockade.

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Section: Introductionmentioning

confidence: 99%

The interaction of the NK₁ receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences

Guard

Boyle

Tang

et al. 1993

British J Pharmacology

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“…Substance P is present in many areas of the CNS and PNS. In the periphery, SP is located especially in areas of immunologic importance, such as the skin, gastrointestinal tract, and respiratory tract [102]. Substance P is synthesized in the dorsal root ganglia, from which it migrates centrally to the dorsal horn of the spinal cord and peripherally to nerve terminals of sensory neurons [103].…”

Section: Substance Pmentioning

confidence: 99%

“…Substance P and other tachykinins are able to cause vasodilation because of direct actions on vascular smooth muscle and enhanced production of nitric oxide by the endothelium [112,113]. In addition, SP can initiate increased vascular permeability and protein extravasation after tissue injury [114,115], enhancing leukocyte infiltration to tissues [102]. Also, SP acts as a strong chemoattractant for immune cells.…”

Section: Substance P Contribution To Inflamma-tion and Angiogenesis Imentioning

confidence: 99%

Inflammatory and Angiogenic Abnormalities in Diabetic Wound Healing: Role of Neuropeptides and Therapeutic Perspectives

Tellechea¹

2012

TOCVJ

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Diabetic foot ulceration (DFU) is one of the most costly and debilitating complications of diabetes and is the leading cause of non-traumatic amputations, affecting 15% of the diabetic population. Impaired wound healing in diabetic patients without large-vessel disease has been attributed to microvascular dysfunction, neuropathy, and abnormal cellular and inflammatory responses. These abnormalities have been examined mainly in animal models although a few studies have been undertaken in diabetic patients. This review provides an overview of the inflammatory and vascular abnormalities in DFU and emphasises the role of angiogenic growth factors, endothelial progenitor cells (EPCs), and neuropeptides as mediators of wound healing and potential therapeutic agents for these chronic, non-healing ulcers.

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“…Because pharyngolaryngeal mucosa receives innovation of nonmyelinated C-fibers (21), and these nerves contain neuropeptides having a variety of biologic activities including pain transmission (21), nonmyelinated Cfibers may play an important role in both reflexes. Jin et al (22) studied the swallowing reflex elicited by injections of distilled water into the pharynx of guinea pigs treated with and without systemic capsaicin, which is known to selectively act on nonmyelinated C-fibers (23).…”

Section: Mechanisms Of Swallowing and Cough Reflexesmentioning

confidence: 99%

New Strategies for Aspiration Pneumonia.

et al. 1997

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Aspiration pneumonia is associated with decreases in both swallowing and cough reflexes and is the most common cause of death in the elderly. Basal ganglia strokes might predispose these patients to develop pneumonia owing to reductions of both reflexes, resulting in frequent aspiration during sleep. An impairment of dopamine metabolism in the basal ganglia is observed in these patients and levodopa administration improves the impaired swallowing reflex. Both swallowing and cough reflexes are mediated by endogenous substance P (SP) released from vagal sensory nerves in the pharynx and upper airways. The addition ofa low dose ofcapsaicin to liquid or food, which stimulates the release of SP, may help prevent aspiration pneumonia. Angiotensin-converting enzyme inhibitor decreases SP catabolism resulting in improvements in both reflexes. Oral care and the sitting position after meals maydecrease aspiration pneumoniain the elderly. (Internal Medicine 36: 851-855, 1997)

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Research on Tachykinins: Clinical Trends

Cited by 125 publications

References 16 publications

The interaction of the NK₁ receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences

The interaction of the NK₁ receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences

Inflammatory and Angiogenic Abnormalities in Diabetic Wound Healing: Role of Neuropeptides and Therapeutic Perspectives

New Strategies for Aspiration Pneumonia.

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Research on Tachykinins: Clinical Trends

Cited by 125 publications

References 16 publications

The interaction of the NK1 receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences

The interaction of the NK1 receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences

Inflammatory and Angiogenic Abnormalities in Diabetic Wound Healing: Role of Neuropeptides and Therapeutic Perspectives

New Strategies for Aspiration Pneumonia.

Contact Info

Product

Resources

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The interaction of the NK₁ receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences

The interaction of the NK₁ receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences