Research on Preparation of 5-ASA Colon-Specific Hydrogel Delivery System without Crosslinking Agent by Mechanochemical Method

5-Aminosalicylic Acid Loaded Chitosan-Carrageenan Hydrogel Beads with Potential Application for the Treatment of Inflammatory Bowel Disease

“…When the medium is changed from acidic to alkaline with a phosphate buffer saline pH = 6.8, a burst release of the drug is also observed to be caused by the sudden transition of the beads into an environment with a different pH, damaging the drug delivery system [ 41 ]. However, the influence of the kCG layer helped to decrease this release and the lowest value, 31%, is found to be for the particles that were kept for 1 h in kCG solution ( Figure 7 A), compared to value of 40% in the hydrogel beads without kCG.…”

Mechanochemical Transformations of Biomass into Functional Materials

“…[267] Chitosan containing composites have the potential to be used in various applications such as drug delivery agent, emulsifier, biomedicine, or high-temperature-humidity-resistant materials. [268,269] In response to the recent trend of pursuing "greener" chemical processes, mechanochemical methods have been heavily studied for their advantages over conventional methods of synthesis for this class of materials. Yang et al reported a method to prepare superamphiphobic nanofibrillated-cellulose/chitosan/Octadecyltrichlorosilane(OTS) composite with a mechanochemical pretreatment step.…”

“…[270][271][272][273] Although colon-specific hydrogels have been successfully prepared through condensation, solvent evaporation, fluidized bed technology, ionic gelation, polymerization, and spray-drying techniques, [274] Xu et al presented a work in which they prepared the hydrogel with a solid-state ball milling process. [269] 5-Amino salicylic acid (5-ASA) colontargeted delivering hydrogel was successfully synthesized without use of a crosslinking agent. [269] The in-vitro study performed in simulated gastric juice determined that the pH-sensitive hydrogel had a release rate of 28.19 %, which was significantly lower than that of 5-ASA active pharmaceutical ingredient (API), while in-vivo study revealed that the release was similar between 5-ASA delivering hydrogel and 5-ASA API, suggesting the prepared drug delivery system could significantly improve the treatment effectiveness with lower 5-ASA dosage, dosing frequency, and causing diminished side effects.…”

“…[269] The in-vitro study performed in simulated gastric juice determined that the pH-sensitive hydrogel had a release rate of 28.19 %, which was significantly lower than that of 5-ASA active pharmaceutical ingredient (API), while in-vivo study revealed that the release was similar between 5-ASA delivering hydrogel and 5-ASA API, suggesting the prepared drug delivery system could significantly improve the treatment effectiveness with lower 5-ASA dosage, dosing frequency, and causing diminished side effects. [269] Mechanochemical copolymerization is another area in which works have been done in recent years. For instance, chitosan has been explored as one of the co-components thanks to the properties it may confer to the resulting copolymers.…”

Mechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by NSAIDs

“…Xu et al. ( 2021 ) used a planetary ball mill to prepare solid dispersion of 5-aminosalicylic acid with chitosan and sodium alginate as carriers, which formed a hydrogel in aqueous solution and could realize localized release in the colon, thereby achieving the purpose of treating ulcerative colitis. Kong et al.…”