“…HC is intentionally produced by a hydrodynamic cavitation reactor (HCR), therefore, its structure generally determines the cavitation intensity and consequent treatment effectiveness of HC technology, indicating the importance of designing high-performance HCRs [28] , [29] , [30] . Recently, the advanced rotational HCRs (ARHCRs), which possess different structures and generation mechanisms from the popular conventional HCRs (e.g., Venturi, orifice, and vortex diode), have attracted increasing attention from the academic and industrial communities, due to high treatment effectiveness and process rate [31] , [32] . Some ARHCRs with fine design can be operated in a continuous mode for biodiesel production [23] , [33] , [34] , microbial inactivation of milk [35] , [36] , and pretreatment of lignocellulose biomass (e.g., commercialized products from BioBANG company), demonstrating great potential for industrial-scale applications.…”