Research letter. Thyroid hormone studies in protein-energy malnutrition

Bk, Das; Bk, Panda; Dhingra, Radhika; Op, Mishra; Jk, Agarwal

doi:10.1093/tropej/45.6.375

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies conducted by Abrol P et al , Turkey et al and Das BK et al, also showed similar results. 17,18,21 In contrast to present study, study conducted by Orbak Z et al, found that mean TSH levels of children with PEM were higher as compared to controls, study conducted by Kumar S et al, found that mean TSH levels showed a positive increase with increase in severity of PEM with maximum increase been observed in grade III PEM (One-way ANOVA; p= 0.015). 19,20 Normal TSH levels in children with PEM is possibly due to T 4 undergoing intracellular monodeiodination to form T 3 at pituitary level causing negative feedback inhibition of secretion of TSH, central unresponsiveness to low T 3 levels due to low intracellular receptor capacity.…”

Section: Discussioncontrasting

confidence: 86%

“…17,18 Similar results are reported by study done by Kumar S et al, Orbak Z et al and study conducted by Das BK et al, found that mean T 3 levels was significantly lower in malnourished children as compared to controls, however in their study they found no significant difference in mean T 4 levels of cases and controls. [19][20][21] Low T 3 levels in children with PEM is probably due to low binding proteins, impaired thyroxine monodeiodination in liver which leads to decreased peripheral conversion of T 4 to T 3 and elevated corticosteroids which is often seen in children with malnutrition (acts by inhibiting 5' deiodinase system) and low T 4 levels in children with PEM can be due to fall in thyroid secretion rate, depletion of reserves and failure of the adaptive mechanism.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid hormone status in children with protein energy malnutrition

Sandeep

Krishnamurthy

2016

Int J Contemp Pediatr

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Thyroid hormone status in children with protein energy malnutrition

Sandeep

Krishnamurthy

2016

Int J Contemp Pediatr

View full text Add to dashboard Cite

“…With respect to thyroid dysfunction, experimental as well as clinical studies indicate that both PEM [ 27 , 28 ] and pro-inflammatory stimuli, in particular interleukin (IL) signaling [ 29 , 30 ], can reduce extrathyroidal conversion of T4 to T3. Both can interfere with the activity of the 5′-deiodinase system in different ways, resulting in decreased T3 production [ 31 , 32 ]. Consequently, we postulate that low T3 syndrome can be closely associated with MICS and might be a pathological condition and / or maladaptation in CKD patients with MICS.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Clinical Significance of Low T3 Syndrome in Non-Dialysis Patients with Chronic Kidney Disease

et al. 2016

View full text Add to dashboard Cite

BackgroundThere are few data on the prevalence of low T3 (triiodothyronine) syndrome in patients with non-dialysis chronic kidney disease (CKD) and it is unclear whether low T3 can be used to predict the progression of CKD.Material/MethodsWe retrospectively studied 279 patients who had been definitively diagnosed with CKD, without needing maintenance dialysis. Thyroid function was analyzed in all enrolled subjects and the incidence of thyroid dysfunction (low T3 syndrome, low T4 syndrome, and subclinical hypothyroidism) in patients at different stages of CKD was determined.ResultsGlomerular filtration rate (GFR) of CKD patients was estimated as follows: 145 subjects (52%) had GFR <60 ml/min per 1.73 m2; 47 subjects (16.8%) had GFR between 30 and 59 ml/min per 1.73 m2, and 98 subjects (35.1%) had GFR <30 ml/min per 1.73 m2. Among all enrolled subjects, 4.7% (n=13) had subclinical hypothyroidism, 5.4% (n=15) had low T4 syndrome, and 47% (n=131) had low T3 syndrome. In 114 CKD patients in stages 3–5, serum T3 was positively related to protein metabolism (STP, PA, and ALB) and anemia indicators (Hb and RBC), and negatively related to inflammatory status (CRP and IL-6).ConclusionsA high prevalence of low T3 syndrome was observed in CKD patients without dialysis, even in early stages (1 and 2). The increasing prevalence of low T3 as CKD progresses indicates its value as a predictor of worsening CKD. Furthermore, low T3 syndrome is closely associated with both malnutrition-inflammation complex syndrome (MICS) and anemia.

show abstract

“…The results of the present study correlate with investigations conducted by Abrol et al and Turkey et al 2,12 In contrast to our research, Das et al found no significant difference in mean T4 levels of cases and controls, they concluded that normal T4 levels in PEM children were secondary to an adaptive process. 13 Low T4 levels in children with PEM can be due to a fall in thyroid secretion rate, depletion of reserves, and failure of the adaptive mechanism.…”

Section: Discussionmentioning

confidence: 99%

A study of plasma proteins (serum total protein, serum albumin), and thyroid function in children with protein-energy malnutrition

Chatterjee,

Sethi,

Verma

et al. 2023

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: The study's objective was to evaluate and compare total serum protein, serum albumin, and thyroid hormones in children with PEM (protein-energy malnutrition) and healthy controls. Methods: In this cross-sectional study, 100 children with PEM served as cases, while an equal number of age and gender-matched healthy children served as controls. 4 ml of venous blood were taken (3 ml in a plain vial and 1 ml in an EDTA vial) and immediately submitted for further investigation. SPSS software (version 25) was used to analyze the data. A p value of ≤0.05 was considered statistically significant. Results: PEM children have lower serum total protein, albumin level, total T3 (TT3), and total T4 (TT4) levels compared to healthy controls (p<0.0001). Mean TSH levels in cases and controls were nearly similar. There was no significant difference between serum TSH concentrations in PEM children and the controls. Grade I PEM had the highest mean total protein, serum albumin, T3, and T4 levels, followed by grades II, III, and IV. When mean total protein, serum albumin, T3, and T4 levels of each grade of PEM were compared to controls, mean total protein, serum albumin, T3, and T4 levels were substantially lower in each grade of PEM (p<0.0001). Conclusions: PEM children have low serum total protein and albumin levels. This is probably due to decreased oral intake of proteins and reduced biosynthesis. Serum TT3 and TT4 levels are lower in children with PEM than in healthy controls, which is most likely due to reduction in circulating plasma proteins.

show abstract

Research letter. Thyroid hormone studies in protein-energy malnutrition

Cited by 4 publications

References 0 publications

Thyroid hormone status in children with protein energy malnutrition

Thyroid hormone status in children with protein energy malnutrition

Prevalence and Clinical Significance of Low T3 Syndrome in Non-Dialysis Patients with Chronic Kidney Disease

A study of plasma proteins (serum total protein, serum albumin), and thyroid function in children with protein-energy malnutrition

Contact Info

Product

Resources

About