BackgroundThere are few data on the prevalence of low T3 (triiodothyronine) syndrome in patients with non-dialysis chronic kidney disease (CKD) and it is unclear whether low T3 can be used to predict the progression of CKD.Material/MethodsWe retrospectively studied 279 patients who had been definitively diagnosed with CKD, without needing maintenance dialysis. Thyroid function was analyzed in all enrolled subjects and the incidence of thyroid dysfunction (low T3 syndrome, low T4 syndrome, and subclinical hypothyroidism) in patients at different stages of CKD was determined.ResultsGlomerular filtration rate (GFR) of CKD patients was estimated as follows: 145 subjects (52%) had GFR <60 ml/min per 1.73 m2; 47 subjects (16.8%) had GFR between 30 and 59 ml/min per 1.73 m2, and 98 subjects (35.1%) had GFR <30 ml/min per 1.73 m2. Among all enrolled subjects, 4.7% (n=13) had subclinical hypothyroidism, 5.4% (n=15) had low T4 syndrome, and 47% (n=131) had low T3 syndrome. In 114 CKD patients in stages 3–5, serum T3 was positively related to protein metabolism (STP, PA, and ALB) and anemia indicators (Hb and RBC), and negatively related to inflammatory status (CRP and IL-6).ConclusionsA high prevalence of low T3 syndrome was observed in CKD patients without dialysis, even in early stages (1 and 2). The increasing prevalence of low T3 as CKD progresses indicates its value as a predictor of worsening CKD. Furthermore, low T3 syndrome is closely associated with both malnutrition-inflammation complex syndrome (MICS) and anemia.

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Facial fracture repair is time-dependent. Early reduction and fixation after trauma help with later repair. Abnormal healing caused by delayed repair increases not only the difficulty of reconstruction, but also the risk of aesthetic or functional defects. Digital technology was used to model local trauma in three dimensions. The fracture fragments were reset, and the facial shape was reconstructed on the reset model. After resampling, 3D printing was used to construct a personalised external fixation helmet. Combined with the posterior nasal passage lift reduction technique, early reduction of the mid-face fractures was performed. Through the early application of a 3D-printed personalised external fixation helmet to a patient with a comprehensive fracture, the helmet manufacturing process and application methods were introduced, and the effect of this application was investigated. In the treatment of facial fractures, the early application of a 3D-printed personalised external fixation helmet is conducive to fracture reduction and fixation and reduces the difficulty of later reconstruction.