Research hotspots and trends of microRNA in periodontology and dental implantology: a bibliometric analysis

Abstract

Background: Periodontal disease is a leading cause of tooth loss, and microRNA (miRNA) has been shown to regulate various biological processes. This study aimed to quantitatively analyze the literature related to miRNA in periodontology and dental implantology and summarize the research hotspots and trends in this field.Methods: Literature records from 1985 to 2020 were obtained from the Web of Science Core Collection database. After manual selection, the data was used for cooperative network analysis, keyword co-occurrence analysis, and reference co-citation analysis and visualized by CiteSpace.Results: A total of 287 papers were analyzed between 2007 and 2020, and more than 95% of them were published in the past decade. The largest number of publications were from China, followed by the USA and Japan. The direct cooperation among the productive institutions was not close. At present, most of the research belongs to the discipline of dentistry, oral surgery, cell biology, and molecular biology. Literature clusters generated by reference co-citation analysis and keyword co-occurrence network showed that previous studies mainly focused on four hotspots: periodontal ligament stem cells (PDLSCs), the pathological process of periodontitis, osteogenic differentiation/bone regeneration, and the competing endogenous RNA (ceRNA) network. Conclusions:The therapeutic potential of miRNA in promoting bone formation and how the ceRNA network contributes to miRNA regulation at a deeper level have become the two main research trends of this field.

Current Trends and Research Hotspots in Pancreatic Stellate Cells: A Bibliometric Study

“…It can systematically visualize the development of the research topics and show the current trends and hotspots of a certain field. Moreover, it has been widely used across many research fields ( 17 ). Citespace software ( 18 ), VOSviewer (visualizations of similarities, van Eck and Waltman, Leiden University, Leiden, Netherlands) ( 19 ) software, and the Online Analysis Platform of Literature Metrology ( ) can be used for detailed analysis of countries/regions, institutions, journals, authors, co-citations and keywords of a certain field.…”

Scientific Outputs of Hypertensive Retinopathy

“…Vosviewer identifies each of the clusters in the literature network by selecting sample phrases from the cited literature. By analyzing the citation network and keywords in the time dimension to discover the development, flourishing, and collapse of certain research clusters, we may detect the research hotspots and trends of a given era (Gao et al, 2021). According to our findings, the difference between coauthorship and citation figures showed that this subject is a global concern and needs to much more international collaboration studies (co-authorship).…”

Study of the Effect of Intestinal Microbes on Obesity: A Bibliometric Analysis

“…According to Table S1, the total number of publications in the USA (87,065) was greater than that in China (65,250) and far greater than that in France (13,809), Canada (13,496), and the other top 10 most cited countries. The total citations of the United States and China are far more than the other top 10 most cited country citations combined.…”

“…China ranked first with 3036 publications, accounting for 34.16% of all publications, followed by the United States (2356, 26.51%) and Spain (480, 5.40%) (Table 1, Figure 2a). Nevertheless, the United States tops the ranking of the most cited countries with a frequency (number of documents) of 87,065, followed by China (65,250), France (13,809), and Canada (13,496) (Table S1). The country collaboration map shows the overall perspective of country and region academic cooperation (Figure S1).…”