Research advances and applications of nucleic acid-modified techniques for biomedical nanomaterial

Zhang, Na; Ma, Ping; Xu, Shixin; Fan, Ailong; Zhao, Yanxin; Wang, Xue; Luo, Yane; Fan, Haiming

doi:10.1016/j.jallcom.2018.01.251

Cited by 2 publications

(2 citation statements)

References 157 publications

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“…Recently, nanoparticles conjugation to functional aggregates caused rapid enrichment of small-sized nanoparticles and reduced systemic toxicity compared with the same concentration of large-sized particles. 10,11 Furthermore, the functional scaffolds of free nanoparticles, assembled by low molecular weight polymers, 12 polypeptides, 13 nucleic acids, 14 and viruses can provide sufficient binding sites for nanoparticles and improve their utilization in vitro and vivo. [15][16][17] With the advent of nanotechnology, SPION assemblies can possess various morphologies and multifunctionalities.…”

Section: Introductionmentioning

confidence: 99%

Design and Preparation of “corn-like” SPIONs@DFK-SBP-M13 Assembly for Improvement of Effective Internalization

Zhang¹,

Wu²,

Liang³

et al. 2021

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have exhibited preeminent diagnosis and treatment performances, but their low internalization severely limits predesigned functions. The low cell internalization is now an urgent bottleneck problem for almost all nanomaterials. To achieve more internalization of SPIONS, recombinant M13 phage was designed for targeted delivery and smart release. Methods: M13 phages were designed to co-express exogenous SPARC binding peptide (SBP) and cathepsin B cleavage peptide (DFK), formed recombinant DFK-SBP-M13. 3.37± 0.06 nm of SPIONs were modified by 3, 4-dihydroxyhydrocinnamic acid (DHCA) to gain 10.80 ± 0.21 nm of DHCA-coated SPIONs, i.e., DHCA@SPIONs. Upon adjusting the proportions of DHCA@SPIONs and DFK-SBP-M13, the multi-carboxyl SPIONs assembled onto recombinant M13 phages via covalent bonding. The assemblies were co-cultured with MDA-MB-231 cells to interpret their internalization and smart release.

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Section: Introductionmentioning

confidence: 99%

Design and Preparation of “corn-like” SPIONs@DFK-SBP-M13 Assembly for Improvement of Effective Internalization

Zhang¹,

Wu²,

Liang³

et al. 2021

IJN

Self Cite

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“…Thus, synthesizing a kind of nanoparticles with high compatibility is important. There are many former reports which had highlight the importance of interface compatibility between inorganic and organic materials and made great progress in medicine science and biological research, but the application in chemical science such as self‐healing polymers materials was rarely reported before.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of Magnetic Self‐Healing Polymers: An Effective Method for Improving Interface Compatibility of Doped Functional Polymers

Zhao

Liao

et al. 2019

ChemNanoMat

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Doped functional polymers, such as magnetic self‐healing polymers based on magnetic inorganic nanoparticles, have raised great attention and been applied in many fields recently due to their superior properties. However, the deficiency of interface compatibility between the inorganic nanoparticles and organic polymers, and the sedimentation and non‐uniform dispersion of the inorganic nanoparticles led to difficulties in the fabrication and development of doped functional polymer materials. In this work, we took magnetic doped self‐healing polymers as an example and proposed an accessible method to solve the problem. We prepared organic‐polymer‐coated Fe3O4 nanoparticles with high interface compatibility and then applied them to successfully synthesize magnetic self‐healing polymers. The average size of the resulting coated Fe3O4 nanoparticles was 8.82±1.09 nm, the practical saturation magnetization of the nanoparticles and the magnetic self‐healing polymers was 83.35, 24.29 emu/g, respectively. In addition, the self‐healing efficiency of the magnetic self‐healing polymers could reach 74.3% when healing for 1 hour and 78.4% when adding a magnetic field compared with 75.8% for the pure self‐healing polymers and 34.5% of magnetic polymers based on pure Fe3O4 nanoparticles. This work may offer a reference in fabricating doped functional polymers based on inorganic nanoparticles with high interface compatibility.

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Research advances and applications of nucleic acid-modified techniques for biomedical nanomaterial

Cited by 2 publications

References 157 publications

Design and Preparation of “corn-like” SPIONs@DFK-SBP-M13 Assembly for Improvement of Effective Internalization

Design and Preparation of “corn-like” SPIONs@DFK-SBP-M13 Assembly for Improvement of Effective Internalization

Synthesis and Properties of Magnetic Self‐Healing Polymers: An Effective Method for Improving Interface Compatibility of Doped Functional Polymers

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