Res Scintigraphy in Polycythemia Vera and Secondary or Relative Polycythemia

Abstract

Scintigraphy of the reticuloendothelial system (RES) was performed in 19 patients with polycythemia vera (PCV) and in 18 with secondary or relative polycythemia (PS). Bone marrow extension was found in all patients with PCV and in II of 18 patients with PS. The patients with PCV had a higher degree of extension than those with PS. Increased pelvic bone marrow activity was found in 16 of 19 PCV patients, but in none with PS. Splenomegaly was found in 9 patients with PCv, and in none with PS. It is concluded that RES scintigraphy in the majority of patients may differentiate between PCV and PS using the parameters pelvic bone marrow activity, bone marrow extension and splenic size.

Proliferative characteristics of Philadelphia‐negative myeloproliferative neoplasms ‐ clinical implications

“…In BM cultures, we found that the total number of EC in PV was significantly higher than the values observed in ET, PMF1, and PMF2, which was attributed to the enhanced number of both eBFU‐E and eCFU‐Mk. This finding in PV could be explained by expanded active BM , as well as the presence of JAK2V617F mutation in all pts . In the PMF1 group, we did not observe differences in the number of total EC between BM and PB.…”

Patients with idiopathic myelofibrosis show increased CD34+ cell concentrations in peripheral blood compared to patients with polycythaemia vera and essential thrombocythaemia

“…On the other hand, it was shown that the concentration of CD34 + cells was not elevated in the bone marrow of PV patients (5). Possible explanations for these diverging findings were that the bone marrow is expanded in PV (19) or that the CD34 + cells originate from a source outside the bone marrow, e.g. the enlarged spleen frequently present in PV (20).…”