Repurposing of antidepression drug sertraline for antimicrobial activity againstStaphylococcus aureus: a potential approach for the treatment of osteomyelitis

Abstract

We report a potential approach to synthesize the repurposed sertraline drug-loaded hydroxyapatite nanoparticles using eggshell as the calcium source via the in situ precipitation method for the treatment of osteomyelitis.

Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces

“…The double band at 2857-2927 cm -1 is assigned to C-H stretching confirm the presence of carbon-chains on the nanoshell surface. Interestingly, sharp peaks at 3570 cm -1 due to OH stretching in highly crystalline CaP powders, 23,24 is absent in CaPLiLX spectrum. However, it should be noted that CaP nanoparticles deposited in the absence of liposomes, but otherwise identical experimental conditions, present a spectrum coincident with that of hydroxyapatite with a distinctive sharp peak at 3570 cm -1 .…”

“…Furthermore, no diffraction patterns were observed in HR-STEM images. [24][25][26] Page 10 of 29 New Journal of Chemistry 1 2 3 4 5 6 7 8 9 Two experimental conditions favored the precipitation of an amorphous CaP (ACP) shell. On one hand, the Ca/P molar ratio added to the liposomes in order to deposit the CaP shell is 1.0, without considering the lipids phosphate head groups.…”

Repurposing the Antibacterial Activity of Etoposide─A Chemotherapeutic Drug in Combination with Eggshell-Derived Hydroxyapatite

“…Single nanoparticle-based bioprobes for multimodal imaging are under constant search. Similarly, single nanoparticles for multifunctions like therapy and diagnosis have gained importance in the last decade. , Also, repurposing of drugs apart from the scope of their original medical indication is now gaining much attention, and has resulted in success for a number of diseases and thus become a hot topic of research . Another approach is exploring the multiple activities of a single drug.…”

“…43,44 Also, repurposing of drugs apart from the scope of their original medical indication is now gaining much attention, and has resulted in success for a number of diseases and thus become a hot topic of research. 45 Another approach is exploring the multiple activities of a single drug. In the present work, etoposide, an anticancer drug, is explored for its antibacterial activity in addition to its anticancer activity in combination with eggshell-derived HA.…”

Precise engineering of ultrasound-mediated cerium oxide nanoparticles: Investigations on antioxidant, antibacterial activity and human osteomyelitis

“…The oral delivery of antibiotics can result in systemic toxicity associated with renal and liver complications and poor penetration into the targeted site. Hence, an alternative strategy of antibiotic delivery should be explored [5][6][7][8]. Recently, development of a local drug delivery system received much attention since antibiotics are delivered locally, the side effects and the risk of overdose of oral administration can be avoided and high concentration of drugs can effectively reach the targeted site.…”