Reprogramming sphingolipid glycosylation is required for endosymbiont persistence in Medicago truncatula

Moore, William M.; Chan, Charles; Ishikawa, Toshiki; Rennie, Emilie A.; Wipf, Heidi M.-L.; Benites, Veronica T.; Kawai‐Yamada, Maki; Mortimer, Jenny C.; Scheller, Henrik Vibe

doi:10.1016/j.cub.2021.03.067

Cited by 18 publications

(17 citation statements)

References 74 publications

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“…Meanwhile, AMF are separated from the plant cytoplasm by a specialized host-derived membrane, which represents the main interface facilitating the bidirectional exchange of nutrients and information. The biosynthesis of this periarbuscular membrane is controlled by a gene called glucosamine inositol phosphorylceramide transferase 1 (Moore et al, 2021). The endophytic fungus S. indica secretes specific proteins to improve its access to micronutrients and to influence oxidative stress and reactive oxygen homeostasis to support the colonization of the host plant (Nostadt et al, 2020).…”

Section: Colonization Phasementioning

confidence: 99%

Transcriptomic and Metabolomic Approaches Deepen Our Knowledge of Plant–Endophyte Interactions

et al. 2022

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In natural systems, plant–symbiont–pathogen interactions play important roles in mitigating abiotic and biotic stresses in plants. Symbionts have their own special recognition ways, but they may share some similar characteristics with pathogens based on studies of model microbes and plants. Multi-omics technologies could be applied to study plant–microbe interactions, especially plant–endophyte interactions. Endophytes are naturally occurring microbes that inhabit plants, but do not cause apparent symptoms in them, and arise as an advantageous source of novel metabolites, agriculturally important promoters, and stress resisters in their host plants. Although biochemical, physiological, and molecular investigations have demonstrated that endophytes confer benefits to their hosts, especially in terms of promoting plant growth, increasing metabolic capabilities, and enhancing stress resistance, plant–endophyte interactions consist of complex mechanisms between the two symbionts. Further knowledge of these mechanisms may be gained by adopting a multi-omics approach. The involved interaction, which can range from colonization to protection against adverse conditions, has been investigated by transcriptomics and metabolomics. This review aims to provide effective means and ways of applying multi-omics studies to solve the current problems in the characterization of plant–microbe interactions, involving recognition and colonization. The obtained results should be useful for identifying the key determinants in such interactions and would also provide a timely theoretical and material basis for the study of interaction mechanisms and their applications.

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Section: Colonization Phasementioning

confidence: 99%

Transcriptomic and Metabolomic Approaches Deepen Our Knowledge of Plant–Endophyte Interactions

et al. 2022

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“…2018 ). Glycosylated sphingolipids may play a role in PAM formation or the regulation of its protein composition, as a M. truncatula GLUCOSAMINE INOSITOL PHOSPHORYLCERAMIDE TRANSFERASE1 ( GINT1 ) gene required for the glycosylation of N -acetyl-glucosamine-decorated glycosyl inositol phosphoryl ceramides is required for arbuscule maturation and branching ( Moore et al. 2021 ).…”

Section: Lipid Composition Of the Pammentioning

confidence: 99%

Functions of Lipids in Development and Reproduction of Arbuscular Mycorrhizal Fungi

Kameoka

Gutjahr

2022

Plant and Cell Physiology

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Arbuscular mycorrhizal fungi (AMF) form mutualistic associations with most land plants. The symbiosis is based on the exchange of nutrients: AMF receive photosynthetically fixed carbon from the plants and deliver mineral nutrients in return. Lipids are important players in the symbiosis. They act as components of the plant-derived membrane surrounding arbuscules, as carbon sources transferred from plants to AMF, as a major form of carbon storage in AMF, and as triggers of developmental responses in AMF. In this review, we describe the role of lipids in AM symbiosis and AMF development.

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“…Complementation of A. thaliana gmt mutants with either A. thaliana or O. sativa GINT recovered total GIPC levels, with GlcNAc replacing Hex, but only partially rescuing the developmental phenotype of these mutants. Further evidence of the significance of Hex/HexNAc content of GIPCs was recently found in the roots and nodules of the model legume Medicago truncatula by Moore et al (2021) . MtGINT1 , the gene required for transferring HexNAc headgroups to GIPCs, is expressed in tissues synthesizing perimicrobial membranes that directly interact with both bacterial (nodulating rhizobia) and fungal (arbuscular mycorrhiza) root symbionts.…”

Section: Clues From a Model Monocot: Oryza Sativamentioning

confidence: 86%

“…Profiling of diverse species by Cacas et al (2013) revealed patterns in the number of sugar headgroups added to different lineages. It is equally fascinating that multiple recent studies have uncovered specific functions for specific GIPC modifications in plant physiology and biotic interactions ( Grison et al , 2015 ; Lenarčič et al , 2017 ; Jiang et al , 2019 ; Moore et al , 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Diversity in sphingolipid metabolism across land plants

Haslam¹,

Feußner

2022

Journal of Experimental Botany

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Sphingolipids are essential metabolites found in all plant species. They are required for plasma membrane integrity, tolerance of and responses to biotic and abiotic stresses, and intracellular signalling. There is extensive diversity in the sphingolipid content of different plant species, and in the identities and roles of enzymes required for their processing. In this review, we survey results obtained from investigations of the classical genetic model Arabidopsis thaliana, from assorted dicots with less extensive genetic toolkits, from the model monocot Oryza sativa, and finally from the model bryophyte Physcomitrium patens. For each species or group, we first broadly summarize what is known about sphingolipid content. We then discuss the most insightful and puzzling features of modifications to the hydrophobic ceramides, and to the polar headgroups of complex sphingolipids. Altogether, this data can serve as a framework for our knowledge of sphingolipid metabolism across the plant kingdom. This chemical and metabolic heterogeneity underpins equally diverse functions. With greater availability of different tools for analytical measurements and genetic manipulation, our field is entering an exciting phase of expanding our knowledge of the biological functions of this persistently cryptic class of lipids.

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Reprogramming sphingolipid glycosylation is required for endosymbiont persistence in Medicago truncatula

Cited by 18 publications

References 74 publications

Transcriptomic and Metabolomic Approaches Deepen Our Knowledge of Plant–Endophyte Interactions

Transcriptomic and Metabolomic Approaches Deepen Our Knowledge of Plant–Endophyte Interactions

Functions of Lipids in Development and Reproduction of Arbuscular Mycorrhizal Fungi

Diversity in sphingolipid metabolism across land plants

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