Reproductive potential of male Portan rats exposed to various levels of lead with regard to zinc status

Nehru, Bimla; Bansal, M. P.

doi:10.1079/bjn20031066

Cited by 35 publications

(27 citation statements)

References 24 publications

(27 reference statements)

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“…In cell kinetic studies, significant declines in various cell populations, spermatids and mature spermatozoa were detected. [27] It has been shown that lead is able to induce lipid peroxidation, one of the main manifestations of oxidative stress. [28] As compared with the controls, the lead-exposed group of rats showed alteration of the histopathologic pattern and reduction in the size of seminiferous tubules, basal membrane separation and a decrease in the cell content of the germinal layer, lesions of the spermatocytes and spermatids, and slight oedematous dissociation in the interstitium similar to our results.…”

Section: Discussionmentioning

confidence: 99%

Lead-induced alterations in rat kidneys and testesin vivo

Massányi

Lukáč

Makarevich³

et al. 2007

Journal of Environmental Science and Health, Part A

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The purpose of this study was to assess the effects of lead administration on the kidney and testicular structure of adult rats. Rats received lead (PbNO(3)) in single intraperitoneal dose 50 mg/kg (group A), 25 mg/kg (group B) and 12.5 mg (group C) per kilogram of body weight and were killed 48 h following lead administration. After the preparation of histological samples the results were compared with control. After the lead administration dilated Bowman's capsules and blood vessels in interstitium of kidney with evident hemorrhagic alterations were noted. Quantitative analysis determined increased relative volume of interstitium and tubules. Also, the diameter of renal corpuscules, diameter of glomeruli and diameter of Bowman's capsule were significantly increased, especially in group A, with the highest lead concentration. In testes, dilatation of blood capillaries in interstitium, undulation of basal membrane and occurrence of empty spaces in seminiferous epithelium were detected. An apoptosis assay confirmed increased incidence of apoptosis in the spermatogenetic cells after the lead administration. Also further morphometric analysis showed significant differences in evaluated parameters between control and treated groups. The number of cell nuclei was decreased in lead-treated groups, which is concerned with the occurrence of empty spaces as well as with the higher apoptosis incidence in germinal epithelium. This study reports a negative effect of lead on the structure and function of kidney and testes.

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Section: Discussionmentioning

confidence: 99%

Lead-induced alterations in rat kidneys and testesin vivo

Massányi

Lukáč

Makarevich³

et al. 2007

Journal of Environmental Science and Health, Part A

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“…Egypt. Nephrotoxicity was induced by giving rats lead acetate dissolved in distilled water at dose 50 mg/kg body weight/ day by gastric tube [20].…”

Section: Induction Of Nephrotoxicitymentioning

confidence: 99%

Dose-Dependent Effect of Coriander (Coriandrum Sativum L.) and Fennel (Foeniculum Vulgare M.) on Lead Nephrotoxicity in Rats

2016

International Journal of Research Studies in Biosciences

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“…Unlike Zn and Ge, Pb is not beneficial to health. Pb can result in neurologic [61,62,63], skeletal, reproductive [64,65], hematopoietic [66,67], and urinary system [68,69] toxicity.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Blood Concentrations of Zinc, Germanium, and Lead and Relevant Environmental Factors in a Population Sample from Shandong Province, China

Xu²,

Shao³

et al. 2017

IJERPH

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Trace elements, including zinc (Zn) and germanium (Ge), are essential for health; deficiency or excess levels of trace elements results is harmful. As a result of industrial and agricultural production, Pb widely exists in people’s living environment. It is absorbed mainly through the respiratory and digestive tracts, producing systemic harm. Reference values for a normal, healthy population are necessary for health assessment, prevention and treatment of related diseases, and evaluation of occupational exposures. Reference ranges for the Chinese population have not been established. From March 2009 to February 2010; we collected data and blood samples (n = 1302) from residents aged 6–60 years living in Shandong Province, China. We measured blood concentrations of Zn, Ge, and Pb using inductively coupled plasma mass spectrometry to determine reference ranges. Results were stratified by factors likely to affect the concentrations of these trace elements: sex, use of cosmetics or hair dye, age, alcohol intake, smoking habits, and consumption of fried food. The overall geometric mean (GM) concentrations (95% confidence interval) were 3.14 (3.08–3.20) mg/L for Zn, 19.9 (19.3–20.6) μg/L for Ge, and 24.1 (23.2–25.1) μg/L for Pb. Blood Zn concentrations were higher in women than in men (p < 0.001), while the opposite was found for Pb (p < 0.001) and sex did not influence Ge (p = 0.095). Alcohol use was associated with higher blood concentrations of Zn (p = 0.002), Ge (p = 0.002), and Pb (p = 0.001). The GM concentration of Zn was highest in 20–30-year-olds (p < 0.001), while Pb concentrations were highest in 12–16-year-olds (p < 0.001). Use of hair dye was associated with lower blood concentrations of Ge (p < 0.05). GM blood concentrations of Pb differed significantly between those who consumed fried foods 1–2 times/month (18.7 μg/L), 1–2 times/week (20.9 μg/L), and every day (28.5 μg/L; p < 0.001). Blood Pb concentrations were higher in subjects who used cosmetics (p < 0.05), hair dye (p < 0.05), and who smoked cigarettes (p < 0.001) than in those who did not.

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Reproductive potential of male Portan rats exposed to various levels of lead with regard to zinc status

Cited by 35 publications

References 24 publications

Lead-induced alterations in rat kidneys and testesin vivo

Lead-induced alterations in rat kidneys and testesin vivo

Dose-Dependent Effect of Coriander (Coriandrum Sativum L.) and Fennel (Foeniculum Vulgare M.) on Lead Nephrotoxicity in Rats

Analysis of Blood Concentrations of Zinc, Germanium, and Lead and Relevant Environmental Factors in a Population Sample from Shandong Province, China

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