Reproductive Outcomes in Women with Uterine Anomalies

Lin, Paul

doi:10.1089/154099904322836438

Cited by 111 publications

(63 citation statements)

References 22 publications

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“…The exact etiology of RPL is not completely understood but the following factors are contributory which include anatomical abnormalities of uterus, endocrine factors, coagulation and immunological causes, infections and chronic diseases, defective placentation, environmental toxins, psychological factors and genetic abnormalities. 8 Mechanical abnormalities account for only 10-15% of cases of recurrent pregnancy loss and are usually thought to cause miscarriage by interrupting the vasculature of the endometrium, prompting abnormal and inadequate placentation 9 . Infections such as listeria monocytogenes, toxoplasma gondii, rubella, HSV, measles, CMV and coxsakie viruses are known or suspected to cause sporadic spontaneous pregnancy loss.…”

mentioning

confidence: 99%

Relationship of insulin resistance with recurrent pregnancy loss

Wani

Gul

Jabeen

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: The recurrent pregnancy loss (RPL) is defined as two and more failed pregnancies as documented by ultrasound and histopathological examination and suggested some assessment after each loss with a thorough evaluation after three or more losses. RPL is one of the most frustrating and difficult areas in reproductive medicine because the aetiology is often unknown and there are few evidence based diagnostic and treatment strategies.Methods: 150 Non pregnant females were taken as both cases and controls in the study. All the pregnancy losses were documented by ultrasound or histological examination after uterine curettage. The control group consisted of women with no RPL with at least one live birth. These two groups were matched on the basis of age and BMI. All the women underwent following examinations, viz. Hysterosalpingography, karyotype of both partners, serum TSH, FT4, prolactin and antibodies for APLA. In addition blood sample were taken for fasting serum glucose and serum insulin level later insulin resistance was calculate using three parameters Fasting insulin > 20IU/ml. Diagnostic of Insulin Resistance. (2) Fasting glucose / Fasting insulin. A ratio of < 4.5 being diagnostic of insulin resistance. (3) HOMA IR. FG (mg/dl) x FPI (IU/ml) FG (mmol/l) x FPI (IU/ml)------------------------------------ OR ----------------------------------- 405 22.5Where 1 mmol/l = 18mg/dl, A value of > 4.5 being diagnostic of insulin resistance.Results: 150 patients were enrolled in this study among which 75 were selected as cases and 75 as controls after fulfilling inclusion and exclusion criteria with mean age cases group was28.4+2.37 years and 29.1+2.70 years in control group mean miscarriage rate in study group was 3.17+83 and control group with 0.35+0.48 with statistically significant difference. Mean fasting glucose (96.5+ 7.86) mg/dl, Fasting Insulin (14.1±5.91) IU/ml. Mean Glucose Insulin ratio (8.1±3.39), HOMA-IR (3.4 ±1.51) in the study group and in control group mean fasting glucose was (87.1+11.49) mg/dl, Fasting Insulin (6.9 ± 4.99) IU/ml. Mean Glucose Insulin ratio (17.8 ±11.44), HOMA-IR (1.5 ±1.27) respectively with statistically significant difference.Conclusions: In women with recurrent pregnancy loss fasting insulin and insulin resistance are higher than those in women without spontaneous abortion. The most sensitive parameter for calculating insulin resistance was found to be fasting insulin followed by HOMA – IR and followed by fasting glucose/fasting insulin ratio. It is therefore important to recommend a fasting insulin and fasting glucose level while evaluating a case of recurrent pregnancy loss to assess for insulin resistance.

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confidence: 99%

Relationship of insulin resistance with recurrent pregnancy loss

Wani

Gul

Jabeen

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…5 Normally, the two mullerian ducts are fused together to create a single uterus, but occasionally these two tubes fail to join. When this happens, two separate uteri form, with double cervices and potentially double vaginas as well.…”

Section: Discussionmentioning

confidence: 99%

Uterus didelphys with multiple fibroids: A case report

Ali

Abdelbadee

Shazly

et al. 2012

Proc Obstet Gynecol

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“…En 2004, Lin [3] avait entrepris une revue de la littérature pour appréhender la différence de devenir obsté-trical chez des femmes avec anomalies müllériennes aussi bien dans l'obtention de grossesse naturelle qu'induite par Assistance médicale à la procréation. Il a comparé ces résultats retrouvés dans une revue de la littérature aux résultats connus de femmes présumées normales.…”

Section: Impact De La Malformation Utérine Sur La Reproductionunclassified

Utérus malformé et Assistance médicale à la procréation: prévention du défaut d'implantation?

Rongières¹

2007

Gynécologie Obstétrique & Fertilité

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Reproductive Outcomes in Women with Uterine Anomalies

Abstract: Women with uterine anomalies have poorer reproductive outcomes and lower pregnancy rates with all conceptions whether spontaneous or induced with ART compared with women with normal uteri.

Cited by 111 publications

References 22 publications

Relationship of insulin resistance with recurrent pregnancy loss

Relationship of insulin resistance with recurrent pregnancy loss

Uterus didelphys with multiple fibroids: A case report

Utérus malformé et Assistance médicale à la procréation: prévention du défaut d'implantation?

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