Reproductive outcome, hormone levels and liver enzymes in agricultural female workers

Ibrahim, K.; Amer, Nagat M.; Tahlawy, Eman M. El; Allah, Heba M. Abd

doi:10.1016/j.jare.2011.01.004

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…Another study on Egyptian women revealed that pregnancy-related problems including abortion and preterm birth are more common among women who farm. Moreover, the increased estradiol and progesterone levels, as well as liver enzymes and a decreased FSH level were significantly observed in female farmers [13].…”

Section: Introductionmentioning

confidence: 91%

General and reproductive health outcomes among female greenhouse workers: a comparative study

et al. 2020

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Background: Agricultural activities as well as exposure to pesticides could have many adverse effects on health status and reproductive outcomes especially in reproductive aged greenhouse workers. The present study aimed to compare the general and reproductive health outcomes between female greenhouse workers and housewives. Methods: This cross-sectional study was conducted on 645 females of reproductive age. They were categorized into two groups according to occupation in greenhouse (308 female greenhouse workers as exposed group and 337 housewives as control group). Participants were interviewed using a questionnaire about reproductive outcomes and occupational status. Clinical measures include blood pressure (BP), pulse and respiratory rate (PR and RR), body mass index (BMI) and hematological parameters. Mann-Whitney U test was used to assess differences between two groups in quantitative variables. Chi-square or Fisher's exact tests was used to determine the differences in the distribution of categorical variables. Data was analyzed using SPSS software version 16. Results: The average daily working hours of the greenhouse workers were 6.94 ± 1.99 h. Only 44.3% of them used personal protective equipment. Data revealed that the rate of spontaneous abortion, infertility, low birth weight (LBW), abnormal births and preterm birth were significantly higher among the greenhouse workers compared to the control group (p ≤ 0.05). The average number of female infants in greenhouse workers was significantly higher than the control group (p ≤ 0.05). Clinical measurements indicated an increase in RR of greenhouse workers and mean of BMI was decreased in them. Hematological parameters demonstrated that there was a significant increase in white blood cells (WBC) and significant decrease in hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) among the female greenhouse workers compared to the control (p ≤ 0.05). Conclusion: Local government efforts is needed to address associated issues including acute effects on health and long-term health risks, resulting from pesticide exposure to greenhouse workers, and gender differences should be considered. Also, occupational health and safety training is necessary and can be helpful in reducing adverse reproductive outcomes.

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Section: Introductionmentioning

confidence: 91%

General and reproductive health outcomes among female greenhouse workers: a comparative study

et al. 2020

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“…Specially considering the female agricultural workers, Ibrahim et al (2011) also found increased AST and ALT levels in a population of 35 pesticide exposed women, as compared to a control group of 50 unexposed women. Their findings along with our findings of indicate that pesticide exposure may lead to hepatic impairment in women.…”

Section: Saúde E Ambientementioning

confidence: 79%

“…Their findings along with our findings of indicate that pesticide exposure may lead to hepatic impairment in women. Still, Ibrahim et al (2011) found that participation of females in agricultural activities exposed to pesticides have not only a negative impact in their liver functions, but in their reproductive health. In this regard, exposure to pesticides have shown to affect the levels of female hormones.…”

Section: Saúde E Ambientementioning

confidence: 99%

Alterações Hematológicas E Bioquímicas Em Indivíduos Expostos a Agrotóxicos: Impacto Da Exposição Direta Versus Indireta

Gonçalves de Souza,

Sonara Aguiar Ramos,

Alves Pedroso

et al. 2024

Interf Cient Saúde Amb

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It is known that individuals directly exposed to pesticides are more susceptible to changes in hematological and biochemical parameters. However, there are no studies comparing the effects of direct and indirect exposure to pesticides on such parameters. This study aimed to verify if individuals indirectly, but still massively exposed to pesticides due to residing or working in agricultural areas with intense pesticide application, exhibit hematological and biochemical alterations. Analyses were conducted on 62 individuals exposed to pesticides residing in a municipality located in the Midwest region of Brazil, with half of them being rural workers directly exposed (occupationally) and the remaining indirectly exposed. Besides hematological and biochemical parameters, sociodemographic, clinical, and occupational parameters were analyzed to discard biases in the study. No significant differences were found regarding the type of exposure in hematological parameters. However, in biochemical parameters, individuals directly exposed to pesticides showed a higher frequency of altered levels of cholinesterase, as well as higher levels of AST, ALT, and GGT compared to those indirectly exposed to pesticides (p<0.05), the latter also in relation to normality parameters. Total cholesterol, VLDL, and triglycerides were significantly elevated in both groups, possibly due to the overweight of the participants. Therefore, this study showed that individuals indirectly exposed to pesticides, although considerably exposed to large quantities of pesticides daily, undergo fewer biochemical alterations than workers directly exposed. However, these results do not exclude the need for monitoring these individuals, nor the possibility of alterations due to indirect pesticide exposure. Further studies involving comparison between rural populations exposed directly and indirectly to pesticides should be conducted in other populations, as exposure profiles may differ from each location due to differences in pesticide loads and application frequencies employed.

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“…Altered liver enzyme activities have been reported among occupational workers exposed to organophosphorus pesticides alone or in combination with organochlorines (Amr, 1999). Ibrahim et al (2011), reported that there was a significant elevation in serum liver enzymes (AST and ALT) in agriculture workers compared to the controls. Increased serum ALP activity may result from physiological or pathological enzyme production and release from non-liver tissue sources (Van Hoof and Broe, 1994).…”

Section: Socio-demographic Characteristics Of Male Agriculture Workersmentioning

confidence: 99%

“…The potential risks to pesticides applicator or farm worker occupationally exposed pesticides are greater than the risks to someone in the general population exposed only to traces of pesticides in food and /or water (Amer et al, 2002). Exposure to low level of pesticides is known to produce a variety of biochemical changes, some of which may be responsible for the adverse biological effects in humans (Elhalwagy et al, 2009;Ibrahim et al, 2011). Conversely, some biochemical alterations may not necessarily lead to clinically recognizable symptoms, although all the biochemical responses can be used as markers of exposure or effect.…”

Section: Introductionmentioning

confidence: 99%

Influence of exposure to pesticides on liver enzymes and cholinesterase levels in male agriculture workers

Awad

El‐Fiki

Abou-Shanab

et al. 2014

Global NEST Journal

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<div> human health and the environment. The study aimed to explore the effects of exposure to pesticides on the liver functions and acetycholinesterase levels in serum (AChES) and red blood cells (AChER) of 100 male participating in agricultural work ranging in age between 20 and 60 year with mean age 37.11±9.3. One hundred males matched for age and socio economic status were recruited as a control group to compare levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilriubin, alkaline phosphatase (ALP), total protein, AChES and AChER. The results indicate that AST, ALT and ALP were significantly (P<0.05) increased in pesticide-exposed workers compared with control. There was also a highly significantly (P<0.01) decrease in AChER among male agriculture workers compared with controls. At 10 - 50 times of pesticides applications there was a significantly (P<0.05) decrease in AChER and increase in AST, ALT and ALP activity among exposed group. However, there was a negative correlation between AST, ALT, direct bilirubin, and AChES and age among control group and a positive correlation between ALT and AST and age among exposed group. According to the number of pesticide application, there was a positive correlation between AST, ALP, total and direct bilirubin and number of pesticide application. Agricultural villages in Egypt require more attention to decrease the percentage of literacy among the farmers and raise their health awareness.  </div>

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Reproductive outcome, hormone levels and liver enzymes in agricultural female workers

Cited by 7 publications

References 27 publications

General and reproductive health outcomes among female greenhouse workers: a comparative study

General and reproductive health outcomes among female greenhouse workers: a comparative study

Alterações Hematológicas E Bioquímicas Em Indivíduos Expostos a Agrotóxicos: Impacto Da Exposição Direta Versus Indireta

Influence of exposure to pesticides on liver enzymes and cholinesterase levels in male agriculture workers

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