Reproductive Health Crisis During Waves One and Two of the COVID-19 Pandemic in India: Incidence and Deaths From Severe Maternal Complications in More than 202000 Hospital Births

Nair, Manisha; Bharti, Omesh Kumar; Bora, Amrit Krishna; Chhabra, Shakuntala; Choudhury, Saswati Sanyal; Choudhury, Arup; Das, Bhanita; Deka, Gitanjali; Jain, Punam; Kakoty, Swapna D.; Kumar, Praveen; Mahanta, Pranabika; Medhi, Robin; Rani, Anjali; Rao, Sereesha; Roy, Indrani; Talukdar, Ratna Kanta; Solomi, Carolin; Thakur, Sita; Verma, Ashok; Zahir, Farzana; Deka, Rupanjali; Opondo, Charles; Kurinczuk, Jennifer J

doi:10.2139/ssrn.3863281

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Contrary to many other studies reporting increased maternal adverse outcomes including a high maternal death rate, especially in India and Brazil [ 22 , 23 ], we had no reported maternal ICU admission requiring intensive monitoring with oxygen supplementation or maternal death. This could be related to the promotion and strict implementation of public health measures, facilities available for treatment, and women's access to the hospitals.…”

Section: Discussioncontrasting

confidence: 98%

COVID-19 Pandemic and Its Impact on Perinatal Outcomes between Symptomatic and Asymptomatic Women

Babic

Alsomali

Aljuhani

et al. 2022

Obstetrics and Gynecology International

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Coronavirus disease 2019 (COVID-19) has been increasing among pregnant women worldwide. Its impact on maternal, fetal, and neonatal health is still scarce in the published literature. As a routine COVID-19 prenatal screening has been established for all women requiring hospitalization, it is not clear whether symptomatic women carry worse pregnancy outcomes than those without symptoms. We aimed to analyze perinatal outcomes between symptomatic and asymptomatic women admitted to our center. Materials and Methods. A single-center retrospective cohort study was conducted for fourteen months. All pregnant women with positive reverse transcriptase-polymerase chain reaction (RT-PCR) test results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were enrolled, and their perinatal outcomes were analyzed in two groups based on whether they were symptomatic or not. The primary outcomes were composite adverse fetal, neonatal, and maternal outcomes and their comparison between study groups. Results. Out of 209 included COVID-19 positive pregnant women, 62 (30%) presented with one or more infection-related symptoms. Symptomatic women were older, multiparous, carried ≥1 comorbid condition, and attained infection at earlier gestational age (44% vs. 28%; 82% vs. 69%; 28% vs. 16%; and 34 vs. 36 weeks, respectively) ( p < 0.05 ), when compared to asymptomatic women, respectively. Maternal composite adverse outcomes were higher in the symptomatic group and showed either one or more outcomes, positive chest radiological findings, requiring hospitalization with oxygen supplementation, or maternal death (8% vs. 0.7%) ( p < 0.05 ). Composite fetal and neonatal adverse outcomes such as miscarriage, fetal or neonatal death, admission to neonatal intensive care unit, and neonatal COVID-19 infection were not statistically significant ( p > 0.05 ) between symptomatic and asymptomatic women. Conclusion. COVID-19 infection among symptomatic pregnant women may carry a higher risk for adverse maternal outcomes. It may be associated with their advanced age and comorbid conditions. Maternal infection-associated symptoms per se likely do not pose an increased risk for adverse fetal or neonatal outcomes.

show abstract

Section: Discussioncontrasting

confidence: 98%

COVID-19 Pandemic and Its Impact on Perinatal Outcomes between Symptomatic and Asymptomatic Women

Babic

Alsomali

Aljuhani

et al. 2022

Obstetrics and Gynecology International

View full text Add to dashboard Cite

show abstract

“…Contrary to many other studies reporting increased maternal adverse outcomes including a high maternal death rate, especially in India and Brazil [22,23], we had no reported maternal ICU admission requiring intensive monitoring with oxygen supplementation or maternal death. is could be related to the promotion and strict implementation of public health measures, facilities available for treatment, and women's access to the hospitals.…”

Section: Discussioncontrasting

confidence: 97%

Covid-19 Pandemic and Its Impact on Perinatal Outcomes Between Symptomatic and Asymptomatic Women

Babic¹

2021

Preprint

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) has been increasing among pregnant women worldwide. Its impact on maternal, fetal, and neonatal health is still scarce in the published literature. As a routine COVID-19 prenatal screening has been established for all women requiring hospitalization, it is not clear whether symptomatic women carry worse pregnancy outcomes than those without symptoms. We aimed to analyze perinatal outcomes between symptomatic and asymptomatic women admitted to our center. Materials and Methods. A single-center retrospective cohort study was conducted for fourteen months. All pregnant women with positive reverse transcriptase-polymerase chain reaction (RT-PCR) test results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were enrolled, and their perinatal outcomes were analyzed in two groups based on whether they were symptomatic or not. e primary outcomes were composite adverse fetal, neonatal, and maternal outcomes and their comparison between study groups. Results. Out of 209 included COVID-19 positive pregnant women, 62 (30%) presented with one or more infection-related symptoms. Symptomatic women were older, multiparous, carried ≥1 comorbid condition, and attained infection at earlier gestational age (44% vs. 28%; 82% vs. 69%; 28% vs. 16%; and 34 vs. 36 weeks, respectively) (p < 0.05), when compared to asymptomatic women, respectively. Maternal composite adverse outcomes were higher in the symptomatic group and showed either one or more outcomes, positive chest radiological ndings, requiring hospitalization with oxygen supplementation, or maternal death (8% vs. 0.7%) (p < 0.05). Composite fetal and neonatal adverse outcomes such as miscarriage, fetal or neonatal death, admission to neonatal intensive care unit, and neonatal COVID-19 infection were not statistically signi cant (p > 0.05) between symptomatic and asymptomatic women. Conclusion. COVID-19 infection among symptomatic pregnant women may carry a higher risk for adverse maternal outcomes. It may be associated with their advanced age and comorbid conditions. Maternal infection-associated symptoms per se likely do not pose an increased risk for adverse fetal or neonatal outcomes.

show abstract

Reproductive Health Crisis During Waves One and Two of the COVID-19 Pandemic in India: Incidence and Deaths From Severe Maternal Complications in More than 202000 Hospital Births

Cited by 2 publications

References 13 publications

COVID-19 Pandemic and Its Impact on Perinatal Outcomes between Symptomatic and Asymptomatic Women

COVID-19 Pandemic and Its Impact on Perinatal Outcomes between Symptomatic and Asymptomatic Women

Covid-19 Pandemic and Its Impact on Perinatal Outcomes Between Symptomatic and Asymptomatic Women

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