Reproductive Function After Conservative Surgery and Chemotherapy for Malignant Germ Cell Tumors of the Ovary

Tangir, Jacob; Zelterman, Daniel; Ma, Wenging; Schwartz, Peter E.

doi:10.1097/00006250-200302000-00010

Cited by 62 publications

(78 citation statements)

References 13 publications

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“…Transient menstrual irregularity or amenorrhea is highly likely to occur in many women during chemotherapy, and a proportion of these patients typically will resume menstruation within 6 months of completion of chemotherapy [4,[30][31][32]. In a previous report among patients who became amenorrheic after chemotherapy, while <11% aged >40 years resumed menses, 22%-56% of those aged <40 years regained menstruation during follow-up [4].…”

Section: The Impact Of Chemotherapeutic Agents On Ovarian Functionmentioning

confidence: 99%

Fertility Preservation in Young Women Undergoing Breast Cancer Therapy

2006

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Section: The Impact Of Chemotherapeutic Agents On Ovarian Functionmentioning

confidence: 99%

Fertility Preservation in Young Women Undergoing Breast Cancer Therapy

2006

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“…More specifi cally, these patients after informed consent can undergo unilateral salpingo-oophorectomy with omental and peritoneal biopsies plus or minus biopsy of the contralateral ovary and pelvic and or para-aortic sampling/dissection in cases with lymph node involvement (14,15). In cases of bilateral ovarian involvement, uterine preservation should be considered and IVF protocols with donor eggs could be used.…”

Section: Discussionmentioning

confidence: 99%

“…Stage Ia tumours do not need adjuvant treatment. However, chemotherapy with schemes such as PEB (cisplatin, etoposide, bleomycin) or JEB (carboplatin, etoposide, bleomycin) or PVB (cisplatin, vinblastine, bleomycin) should be offered in patients with higher stage disease (12,15). Several pregnancies have been reported after surgery and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Brewer et al showed that after chemotherapy, 71 % of patients maintained their normal menstrual function during and after chemotherapy, and 93 % had returned to their pre-chemotherapy menstrual pattern while 35 % achieved pregnancy (18). Radiotherapy of the pelvic and para-aortic lymph node areas is rarely used as fi rst line treatment (15). Ovarian transposition of the contralateral ovary is proposed in such cases.…”

Section: Discussionmentioning

confidence: 99%

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Is fertility sparing surgery a treatment option for premenopausal patients with dysgerminoma?

Iavazzo¹,

Vorgias²,

Iavazzo³

et al. 2017

BLL

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Dysgerminoma is the most common ovarian germ cell type ovarian tumour. Primarily, it presents in young women at reproductive age and thus, the preservation of fertility is considered to be fundamental when it is possible for these patients. In comparison to the past the restriction of the extent of the surgical procedure as well as the introduction of innovative chemotherapeutic regimens improved signifi cantly both, the prognosis and the clinical outcomes of this rare neoplasia. As dysgerminomas are extremely radio-and chemosensitive, fertility sparing approach and less aggressive operations should be favoured. We present a narrative review of the multispecialty fertility sparing surgical and medical approach for women with dysgerminoma (Ref. 21). Text in PDF www.elis.sk.

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“…While there are many theoretical reasons why chemotherapy may induce infertility, it would appear that the risks of this occurring are small. Pektasides 40 17 0% POMB/ACE 6 5 1 (17%) Gershenson (Gershenson, 1988) 40 40 N/A b Various 16 11 5 (31%) Huang (Huang, 1990) 28 26 8% N/A 10 7 3 (30%) Wu (Wu et al, 1991) 28 22 7% Various 10 7 3 (30%) Long (Long et al, 1993) 15 15 N/A N/A N/A 4 N/A Mitchell 69 26 0% Various N/A 11 N/A Brewer (Brewer et al, 1999) 26 16 100% BEP a 5 3 2 (40%) Perrin (Perrin et al, 1999) 45 29 51% Various 9 7 2 (22%) Low (Low et al, 2000) 91 39 42% Various 20 19 1 (5%) Kanazawa (Kanazawa et al, 2000) 31 18 23% Various 9 8 1 (11%) Zanetta (Zanetta et al, 2001) 169 73 41% Various 20 16 4 (20%) Tangir (Tangir et al, 2003) 106 Fertility after chemotherapy for germ cell tumours J Gaffan et al…”

Section: Discussionmentioning

confidence: 99%

Infertility rates following POMB/ACE chemotherapy for male and female germ cell tumours – a retrospective long-term follow-up study

et al. 2003

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The risk of chemotherapy-induced infertility in male and female germ cell tumour (GCT) survivors is unclear, but may correlate with cisplatin dose. Here, we examine a large series of GCT patients for the effect of chemotherapy on those attempting to have children. Our GCT database was screened for nonseminomatous GCT patients who had (1) received POMB/ACE chemotherapy (cisplatin, vincristine, methotrexate, bleomycin alternating with actinomycin D, cyclophosphamide and etoposide) and (2) stage I male GCT patients who were untreated between 1977 and 1996. Fertility was assessed by questionnaire and medical records. A total of 64 of 153 treated and 35 of 115 untreated men attempted to have children. In all, 28% (18 out of 64) receiving POMB/ACE were unsuccessful. Radiotherapy (six), atrophic remaining testis (one) or prior infertility (three) were implicated in 10 cases, so chemotherapy-induced infertility may have occurred in only 11% (eight out of 64). Strikingly, 26% (nine out of 35) of untreated stage I patients also failed to have children (three had radiotherapy, three prior infertility). Moreover, in treated men, no association was seen between cisplatin dose and infertility. In contrast, radiotherapy significantly increased male infertility (P ¼ 0.001). Of 28 treated women who attempted to have children, 25% (seven out of 28) were unsuccessful. One previously had infertility and one subsequently had successful IVF so chemotherapy-induced infertility potentially occurred in only 18% (five out of 28) and was not related to cisplatin dose. In conclusion, the risk of chemotherapy-induced infertility is low in both male and female GCT patients and does not clearly correlate with the cumulative cisplatin dose.

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Reproductive Function After Conservative Surgery and Chemotherapy for Malignant Germ Cell Tumors of the Ovary

Cited by 62 publications

References 13 publications

Fertility Preservation in Young Women Undergoing Breast Cancer Therapy

Fertility Preservation in Young Women Undergoing Breast Cancer Therapy

Is fertility sparing surgery a treatment option for premenopausal patients with dysgerminoma?

Infertility rates following POMB/ACE chemotherapy for male and female germ cell tumours – a retrospective long-term follow-up study

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