Fertility Preservation in Young Women Undergoing Breast Cancer Therapy

Sönmezer, Murat; Oktay, Kutluk

doi:10.1634/theoncologist.11-5-422

Cited by 215 publications

(166 citation statements)

References 148 publications

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“…The combined 5 years relative survival rate for children with cancer has improved from around 63% for patients diagnosed during the period 1975-1979 to 79% for those diagnosed 1995-1999 [2]. Several chemotherapeutic agents [3] and radiotherapy used in cancer treatment are toxic to the ovaries [4].…”

Section: Introductionmentioning

confidence: 99%

Whole sheep ovary cryopreservation: evaluation of a slow freezing protocol with dimethylsulphoxide

Milenković

Wallin

Ghahremani

et al. 2010

J Assist Reprod Genet

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Section: Introductionmentioning

confidence: 99%

Whole sheep ovary cryopreservation: evaluation of a slow freezing protocol with dimethylsulphoxide

Milenković

Wallin

Ghahremani

et al. 2010

J Assist Reprod Genet

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“…Rapid counseling may allow YBCP sufficient time for one or two rounds of egg collection without delaying the start of their cancer treatmeKim et al, 2011). Some investigators have reported that the benefit of GnRH agonist therapy to protection of ovaries is unproven and it should not be offered as individual method of fertility preservation in young breast cancer patient (Sonmezer and Oktay, 2006;Bedoschi et al, 2013). Recent studies suggest that GnRH with chemotherapy in premenopausal women is associated with higher rates of resumption of menses, although it is not associated with improvement in pregnancy rates.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Available Guidelines on Fertility Preservation of Young Patients with Breast Cancer

Haddadi

Muhammadnejad²,

Sadeghi-Fazel³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Since the survival rate of breast cancer patients has improved, harmful effects of new treatment modalities on fertility of the young breast cancer patients has become a focus of attention. This study aimed to systematically review and critically appraise all available guidelines for fertility preservation in young breast cancer patients. Materials and Methods: Major citation databases were searched for treatment guidelines. Experts from relevant disciplines appraised the available guidelines. The AGREE II Instrument that includes 23 criteria in seven domains (scope and purpose of the guidelines, stakeholder involvement, rigor of development, clarity, applicability, editorial independence, and overall quality) was used to apprise and score the guidelines. Results: The search strategy retrieved 2,606 citations; 72 were considered for full-text screening and seven guidelines were included in the study. There was variability in the scores assigned to different domains among the guidelines. ASCO (2013), with an overall score of 68.0%, had the highest score, and St Gallen, with an overall score of 24.7%, had the lowest scores among the guidelines. Conclusions: With the promising survival rate among breast cancer patients, more attention should be given to include specific fertility preservation recommendations for young breast cancer patients.

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“…The Oncologist 2012;17:910 -916 www.TheOncologist.com have a negative impact on ovarian reserve and may cause infertility or premature menopause [7][8][9][10]. This has a significant impact on patients' quality of life, with breast cancer survivors rating infertility, premature menopause, and sexual dysfunction highest of the problems experienced since diagnosis [11].…”

Section: Breast Cancermentioning

confidence: 99%

Fertility preservation in women undergoing treatment for breast cancer in the UK: A questionnaire study

King

Roche

Davies

et al. 2012

European Journal of Surgical Oncology (EJSO)

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Objective. Fertility preservation is an important survivorship issue for women treated for breast cancer. The aim of this work was to examine the referral practices of health care professionals who treat women with breast cancer in the United Kingdom, and to investigate their understanding and knowledge of the fertility preservation options available.Method. An invitation to participate in a confidential, online questionnaire was e-mailed to surgeons, oncologists, and clinical nurse specialists who manage patients with breast cancer in the United Kingdom.Results. n ‫؍‬ 306 respondents. Factors which influenced whether fertility preservation options were discussed with a patient included the following: patient's age (78%), final tumor/nodes/metastasis status (37.9%); concern that fertility preservation would delay chemotherapy (37.3%); whether the patient had children (33.5%) or a partner (24.7%); estrogen receptor expression (22.6%), lack of knowledge regarding the available options (20.9%); and concern that fertility preservation would compromise the success of cancer treatment (19.8%). Twenty-seven percent did not know whether fertility preservation was available for their patients on the National Health Service. Nearly half (49.4%) of respondents said that gonadotropin-releasing hormone agonists were used for fertility preservation outside the setting of a clinical trial. Knowledge regarding the available options varied according to different members of the multidisciplinary team, with consultant oncologists better informed than consultant surgeons or clinical nurse specialists (p < .05).Conclusions. Many health care professionals have incomplete knowledge regarding the local arrangements for fertility preservation for patients with breast cancer. This may result in patients receiving inadequate or conflicting information regarding fertility preservation. The Oncologist 2012;17:910 -916

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Fertility Preservation in Young Women Undergoing Breast Cancer Therapy

Cited by 215 publications

References 148 publications

Whole sheep ovary cryopreservation: evaluation of a slow freezing protocol with dimethylsulphoxide

Whole sheep ovary cryopreservation: evaluation of a slow freezing protocol with dimethylsulphoxide

Systematic Review of Available Guidelines on Fertility Preservation of Young Patients with Breast Cancer

Fertility preservation in women undergoing treatment for breast cancer in the UK: A questionnaire study

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