Reproductive evaluation of two pesticides combined (deltamethrin and endosulfan) in female rats

Presibella, Kenia M.; Kita, Diogo Henrique; Carneiro, Claudia Beleski; Andrade, Andrey José de; Dalsenter, Paulo Roberto

doi:10.1016/j.reprotox.2004.11.007

Cited by 23 publications

(14 citation statements)

References 25 publications

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“…Hileman [5] reported that fenitrithione have the potential to cause reproductive toxicity in animals, affect human reproduction. Okamura and Presibella [6][7] showed some pathological effects of pesticides on the reproductive system of experimental animals. Chlorpyrifose had been obtained testicular damage, damage to sperm production, and reduction in testosterone levels when fed to adult male rats [8].…”

Section: Introductionmentioning

confidence: 99%

The Protective Role of Alpha Lipoic Acid Against pesticides Induced Testicular Toxicity- Histopathological and Histochemical Studies

Gawish¹

2010

J Aquac Res Development

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The present study aimed to investigate the effi ciency of alpha-lipoic acid (ALA) as natural antioxidant in ameliorating some of changes induced by intoxication with a mixture of well known pesticides used in our agricultural media. Four groups of male rats were treated as follows untreated control animals, (p-mix, consists of 1/60LD50 chloropyrifos (2mg/ Kg b.wt) 1/200 LD50 of fenitrothion (2.5 mg/km b.wt) as used in agriculutural environment and ALA 200mg/animal of alpha lipoic acid, (P-mix+ALA). Histological observation of the intoxicated rats revealed signifi cant alterations in the testis tissue of P mix. treated group including focal mild testicular damage, blood hemorrhage and hypospermatogensis, necrosis and atrophy. The degree of fi brosis was encountered using masson-trichrome stain technique which revealed various fi brosis grades between the control and treated testes tissues upon the exposure to the insecticides. TUNEL technique showed an increase in the incidence of positive apoptotic cells between the spermatogonial and germ cells. Also complete depletion of the level of acid phosphatase enzyme which involved in the testosterone biosynthesis. The treatment with alpha lipoic acid showed many degrees of improvements in the seminiferous tubules, spermatogenic germ cells and the interstitial cells. Also decrease in the grades of fi brosis between testis tissues. Conclusion: The biochemical, hiopathological, reports supported that the pesticides have many implicated toxic changes on the testes tissues and the antioxidants like alpha lipoic acid obtained many trials to get ameliorative effects on the toxicity of pesticides.

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Section: Introductionmentioning

confidence: 99%

The Protective Role of Alpha Lipoic Acid Against pesticides Induced Testicular Toxicity- Histopathological and Histochemical Studies

Gawish¹

2010

J Aquac Res Development

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“…Some of the EDs that have been shown to be related to PP in humans are polybrominated biphenyls (Blanck et al 2000a;Blanck et al 2000b), DDT, DDE (Vasiliu et al 2004;Krstevska-Konstantinova et al 2001;Ouyang et al 2005), polychlorobiphenyls (Gladen et al 2000;Denham et al 2005), and phthalate (Colón et al 2000). In this study, endosulphan 1 (endosulphan alpha), endosulphan 2 (endosulphan beta), endosulphan sulphate (Presibella et al 2005;Varayoud et al 2008), methoxychlor (Golub et al 2003;Gray et al 1989;Masutomi et al 2003), vinclozolin (Blystone et al 2009), and isomers of DDT (4,4-DDT, 2,4-DDT, and 4,4-DDE;Vasiliu et al 2004;Krstevska-Konstantinova et al 2001;Ouyang et al 2005), which are pesticides that have been shown to have estrogenic effects, have been evaluated for their effects on early puberty. The mentioned chemicals are the commonly used pesticides in agriculture.…”

Section: Discussionmentioning

confidence: 61%

“…Studies also evaluating the perinatal period are necessary to elucidate this subject. Animal studies have shown that endosulphan has estrogen-like effects (Presibella et al 2005;Varayoud et al 2008). However, there have been no studies evaluating the effects of endosulphan on the development of PP in human beings.…”

Section: Discussionmentioning

confidence: 99%

Effects of pesticides used in agriculture on the development of precocious puberty

Özen

Darcan

Bayındır

et al. 2011

Environ Monit Assess

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The present study aims to evaluate the effects of pesticides on premature breast development. Forty-five girls (group 1) with premature breast development living in the Menderes region, where greenhouse cultivation is the main income, 16 girls (group 2) living in Izmir city with early puberty, and 33 girls (group 3) who had no signs of puberty were included in the study. Endosulphan 1, endosulphan 2, endosulphan sulphate, methoxychlor, vinclozolin, 4,4-dichlorodiphenyldichlorethylene (DDE), 4,-dichlorodiphenyltrichloroethane (DDT), and 2,4-DDT were evaluated in the serum and adipose tissues of the groups by using a gas chromatography-mass spectrometry method. With the exception of 4,4'-DDE, the pesticides studied were undetectable in the serum and adipose tissue samples. The levels of basal luteinizing hormone (LH), stimulated LH, follicle-stimulating hormone, and the long axis of the uterus and both ovaries were significantly different in the girls who had premature thelarche and detectable 4,4'-DDE levels compared to the girls who had premature thelarche and undetectable 4,4'-DDE levels in serum and adipose tissues. The presence and levels of pesticides in serum and adipose tissues were not related to precocious puberty (PP). The mechanisms that lead to PP may also result in obesity, and obesity may be the underlying cause for PP in this group.

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“…Volatile organic compounds (Wagner et al, 1990), heavy metals (Benoff et al, 2000) or xenoestrogens like some polychlorinated biphenyls (Rozati et al, 2002), phthalate esters (Duty et al, 2003) and pesticides (Carreño et al, 2007; may compromise reproductive male function. Pesticides alter the male reproductive function by altering sperm count and sperm shape, alter sexual behavior or increase infertility in animals and human beings (Figà-Talamanca et al, 2001;Sweeney, 2002;Sheiner et al, 2003;Chang et al, 2004;Presibella et al, 2005;Jensen et al, 2006;Joshi and Sharma, 2011). There have *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive effect of acephate on cauda epididymis and accessory sex organs of male rats

Jasuja¹,

Sharma²,

Joshi³

2013

Afr. J. Pharm. Pharmacol.

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In the present study, thirty six (36) adult male Wistar rats were divided into six groups each containing 6 Wistar rats (n = 6). Group I served as untreated control group while group II served as the positive control and group III served as the negative control. Group IV, V and VI were considered as the experimental groups. Group II received tetracyclin (28.6 mg/kg/b.wt/day), while group III received vehicle (olive oil 0.5 ml/100 g body weight/day). Group IV, V and VI were administered "acephate" and dissolved in olive oil at dose level of 25, 50 and 75mg/kg b.wt/day for 30 days, respectively. Reproductive toxicity of acephate was evaluated on the basis of weight analysis of cauda epididymis and accessory sex organs, fertility, sperm dynamics, protein content, sialic acid content and histopathological studies. There was a decrease in the weight of epididymis, ventral prostate, vas deferens and seminal vesicle. The results showed highly significant decline in sperm density and motility. Post fertility test showed 30, 60, and 80% negative results. A statistically significant increase was noticed in protein content whereas sialic acid content was decreased in the cauda epididymis and accessory sex organs. The histopathological observations also support the occurrence of toxicity being caused due to exposure of acephate. The observations are thus indicative of the reproductive toxicity caused by acephate at different dose levels in the male rats.

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Reproductive evaluation of two pesticides combined (deltamethrin and endosulfan) in female rats

Cited by 23 publications

References 25 publications

The Protective Role of Alpha Lipoic Acid Against pesticides Induced Testicular Toxicity- Histopathological and Histochemical Studies

The Protective Role of Alpha Lipoic Acid Against pesticides Induced Testicular Toxicity- Histopathological and Histochemical Studies

Effects of pesticides used in agriculture on the development of precocious puberty

A comprehensive effect of acephate on cauda epididymis and accessory sex organs of male rats

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