Reproductive Disorders

Johnson, Cheri A.

doi:10.1016/b978-1-4377-0657-4.00013-2

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…FSH is a glycoprotein that promotes estradiol production and the secretion of gonadal hormones in females and promotes pubertal spermatogenesis and induces Sertoli cells to secrete androgen binding protein in males. , LH stimulates the production of androgens in males and secretion of progesterone and estrogen in females . FSH, in conjunction with LH, acts as a vital role in reproduction . Therefore, reduction in fshb and lhb expression may contribute to the reduction of E2 concentrations and the ratio of E2/T in females after boscalid treatment, resulting in changes in LV in ovaries and subsequent reductions in fecundity and reproduction.…”

Section: Discussionmentioning

confidence: 99%

“…69 FSH, in conjunction with LH, acts as a vital role in reproduction. 70 Therefore, reduction in fshb and lhb expression may contribute to the reduction of E2 concentrations and the ratio of E2/T in females after boscalid treatment, resulting in changes in LV in ovaries and subsequent reductions in fecundity and reproduction. The decrease in fshb and lhb expression in males may affect gonadal development with alterations in the percentage of SPD and SPG.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis

Qian

Zhang

et al. 2020

Environ. Sci. Technol.

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Boscalid is a succinate dehydrogenase inhibitor fungicide and is frequently detected in surface water. Due to the frequent detection of boscalid, we evaluated its impact on the reproduction of adult zebrafish following a 21 d exposure to 0, 0.01, 0.1, and 1.0 mg/L. Following exposure to boscalid, the fertility of female zebrafish and fertilization rate of spawning eggs were reduced in a concentration-dependent manner up to a respective 87% and 20% in the highest concentration. A significant 16% reduction in the percentage of late vitellogenic oocytes was noted in ovaries, and a significant 74% reduction in the percentage of spermatids in testis was also observed after treatment with 1.0 mg/L. 17β-Estradiol (E2) concentrations decreased significantly in females (34% decrease) but significantly increased in males (15% increase) following 1.0 mg/L boscalid treatment. The expression of genes (such as era, er2b, cyp19a, and cyp19b) related to the hypothalamus-pituitary-gonad-liver (HPGL) axis was significantly altered and positively correlated with E2 concentrations in female and male zebrafish (p < 0.05). Molecular docking results revealed that the binding modes between boscalid and target proteins (ER and CYP19) of zebrafish were similar to that of the reference compounds and the target proteins. The binding energies indicate that boscalid may have a weak estrogen-like binding effect or CYP19 inhibition, potentially altering the HPGL axis, thereby reducing E2 concentrations and fecundity in females. In contrast, boscalid caused significant induction of E2 steroidogenesis and subsequent feminization of gonads in males, indicating gender-specific adverse outcome pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis

Qian

Zhang

et al. 2020

Environ. Sci. Technol.

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“…3 The interval between OHE and the occurrence of signs of oestrus is highly variable. 6,7,9 Signs of oestrus have been reported from a few weeks to several years after OHE. 5,6,7,9 In the cases reported here, signs of oestrus occurred from 3 months to 8 months after OHE.…”

Section: Discussionmentioning

confidence: 99%

Ovarian remnant syndrome and uterine stump pyometra in three queens

Demırel

Acar

2012

Journal of Feline Medicine and Surgery

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Ovarian remnant syndrome (ORS) is the presence of functional ovarian tissue with signs of oestrus as a complication after ovariohysterectomy (OHE) or ovariectomy. Stump pyometra is another complication that can be observed after OHE. However, there are few reports about ORS and stump pyometra in queens. In this report, three queens with recurrent oestrous behaviours after OHE are described. In two queens, ORS with stump pyometra was diagnosed and in one queen ORS alone was diagnosed by physical examination, medical history, vaginal cytology and ultrasonography. Remnant ovarian and uterine tissues were removed by laparotomy. Two queens recovered without any complications; however, one queen died 2 days after surgery. This study reveals that ORS and stump pyometra can result in severe disease and can be fatal.

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Reproductive Disorders

Cited by 2 publications

References 6 publications

Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis

Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis

Ovarian remnant syndrome and uterine stump pyometra in three queens

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