“…Supraphysiologic levels of hormones may adversely affect endometrial receptivity [11,12]. With mild stimulation, potentially detrimental effects of high levels of ovarian hormones such as estradiol and progesterone are minimized.…”
Section: Reasons To Consider Mild Stimulationmentioning
Purpose To provide a perspective regarding mild ovarian stimulation, taking into account particular issues relevant in the United States Methods Literature review and editorial commentary Results Mild ovarian stimulation for IVF has some proven and some theoretical advantages over conventional stimulation, such as lower risk of ovarian hyperstimulation syndrome and lower cost per fresh IVF cycle. However, cumulative live birth rate, including transfers from fresh and frozen embryos, is likely to be lower with mild stimulation. The cost-effectiveness of mild stimulation IVF in the United States has not been established. Conclusions Mild ovarian stimulation is an appropriate option to consider for certain patient groups or based on patient preference. However, significant potential disadvantages limit its widespread acceptability for patients in the United States at this time.
“…Supraphysiologic levels of hormones may adversely affect endometrial receptivity [11,12]. With mild stimulation, potentially detrimental effects of high levels of ovarian hormones such as estradiol and progesterone are minimized.…”
Section: Reasons To Consider Mild Stimulationmentioning
Purpose To provide a perspective regarding mild ovarian stimulation, taking into account particular issues relevant in the United States Methods Literature review and editorial commentary Results Mild ovarian stimulation for IVF has some proven and some theoretical advantages over conventional stimulation, such as lower risk of ovarian hyperstimulation syndrome and lower cost per fresh IVF cycle. However, cumulative live birth rate, including transfers from fresh and frozen embryos, is likely to be lower with mild stimulation. The cost-effectiveness of mild stimulation IVF in the United States has not been established. Conclusions Mild ovarian stimulation is an appropriate option to consider for certain patient groups or based on patient preference. However, significant potential disadvantages limit its widespread acceptability for patients in the United States at this time.
“…Studies have shown than this approach may be beneficial for oocyte/embryo quality [6] and endometrial receptivity [7]. Furthermore, there is preliminary evidence than the mean birth weight of the child is higher when in modified natural cycles compared to conventional stimulated cycles.…”
Section: Healthier Oocytes Embryos and Potentially Higher Birth Weigmentioning
“…Endometrium receptivity is expressed by biologically active molecules growing quantity, such as cytokines, growth factors, adhesion molecules, etc. Traditionally the endometrium receptivity is estimated by biopsy effective enough to assess the lutein phase sufficiency [3,4]. However, this technique does not permit getting full information on the endometrium receptivity.…”
AbstractsBackground: Implantation failure of in vitro fertilization (IVF) cycles is recognized as one of key problems in contemporary reproductive medicine. Implantation itself is a multifactorial process and one can hardly expect to find a single criterion for the endometrium receptivity. Endometrium biopsy still remains the most applicable technique to diagnose abnormalities causing decrease or complete loss of endometrial receptivity. Materials and methods: We have studied 95 endometrial biopsy samples from 45 patient with I/
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